Background. Echinococcosis are parasitic zoonoses, remains a public health problem of worldwide, including Mongolia . Differential diagnosis between E.granulosus and E.multilocularis has significant implications for epidemiologic studies, treatment of these diseases, since both species occur in Mongolia. Serodiagnostic tests based on detection of antibodies against genus and species-specific antigens have played an important role in differential diagnosis, confirming clinical diagnosis and in epidemiologic studies.Materials and Methods. A total of 107 volunteer participants’ serum samples and additional 11 serum samples from the persons with hepatic cysts were tested for specific IgG against recombinant AgB and recombinant Em18 antigens in an ELISA .Results.rAgB-specific antibody was detected in 2 (3.33) of 60 individuals from Bayankhongor province and no one had positive response to this antigen in 46 individuals from Ulaanbaatar city while rEm18-specific antibody was present in 7 (11.66) and 3 (6.38) respectively. The one individual with typical lesions of active echinococcosis in a liver revealed by abdominal ultrasonography showed significantly higher IgG antibody response to rAgB. We suggest that people need to be provided information not only about cystic echinococcosis but also alveolar echinococcosisand improvement of sanitation and hygiene and to be careful with corsac and red foxes and their feces to prevent those infections.