Objective:To investigate the levels of self-compassion, coping style and job burnout of nurses in Operating Room, and to explore the relationship between self-compassion, coping style and job burnout.Methods:Using the convenient sampling method, a total of 263 nurses in the Operating Room of five tertiary hospitals in Beijing and Wuhan were surveyed through the General Data Questionnaire, the Self-compassion Scale (SCS) , Simple Coping Style Questionnaire (SCSQ) , and the Maslach Job Burnout Scale from June to July in 2019. The level of self-compassion and job burnout of nurses in Operating Room were analyzed and the correlation between the self-compassion, coping style and job burnout was analyzed by Pearson linear correlation analysis.Results:A total of 259 valid questionnaires were collected. The nurses in the Operating Room scored (86.42±12.84) points for self-compassion, (1.88±0.57) points for positive coping style, (1.26±0.52) points for negative coping style, and (44.04±19.92) points for job burnout. Pearson linear correlation analysis showed that the total self-compassion score of nurses in the Operating Room was negatively correlated with job burnout ( r=-0.549) , self-compassion was positively correlated with positive coping style ( r=0.556) , positive coping style was negatively correlated with job burnout ( r=-0.362) , and negative coping style was positively correlated with job burnout ( r=0.275) (all P<0.01) . Conclusions:The Operating Room nurses have a moderate level of self-compassion. The higher the level of self-compassion. the more likely to adopt a positive coping style to reduce job burnout. Operating Room managers should also fully recognize the positive significance of self-compassion, help Operating Room nurses improve self-compassion level, promote the formation of positive coping styles, and reduce Operating Room job burnout.