Objective To investigate the effects of graphic health education pathway in patients with osteoporosis after postmenopausal.Methods Totals of 120 cases of perimenopausal patients with osteoporosis were divided into the observation group (n=60) and the control group (n=60) from January 2011 to December 2013.The control group patients were given the routine sexual health education.The observation group was taught with graphic health education for three months.The Osteoporosis Health Belief Scale ( OHBS ) , the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI) and bone mineral density of the two groups were observed and compared before and after the health education.Results In the observation group, the total score of KAP and the score of heath belief, the knowledge of osteoporosis, the prevention healthcare were (139.62 ±32.12), (65.32 ±12.48), (43.69 ±5.78) and (32.12 ±4.56), respectively, which were significantly higher than (105.63 ±28.69), (51.21 ±11.45), (31.25 ±4.96) and (22.62 ±5.12) in the control group after the intervention (t =3.456, 4.362, 5.126, 5.623, respectively;P <0.05).In the observation group, the score of ODI and VAS were ( 23.25 ±5.12 ) and ( 3.86 ±0.75 ) , which were significantly higher than (36.12 ±6.78) and (5.29 ±0.92) in the control group after the intervention (t=4.985, 5.122, respectively;P<0.05).The bone mineral density of lumbar L1 to L4, femoral neck and hip trochanter area and Wards area of the observation group were significantly higher than the control group ( t=4.252, 4.825, 4.312, 4.985, respectively;P<0.05).Conclusions The graphic health education pathway can effectively improve the KAP of osteoporosis patients and the bone mineral density.It can relieve the pain and dysfunction, so as to promote the rehabilitation of patients.