1.Overexpression of human EP4 receptor in vascular smooth muscle cells attenuates angiotensin II-induced hypertension in mice.
Hu XU ; Sai-Lun WANG ; Cheng-Zhen BAO ; Lan YE ; You-Fei GUAN ; Xiao-Yan ZHANG
Acta Physiologica Sinica 2021;73(4):597-605
Prostaglandin E
Angiotensin II
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Animals
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Humans
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Hypertension/chemically induced*
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Mice
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Mice, Inbred C57BL
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Muscle, Smooth, Vascular
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Myocytes, Smooth Muscle
2.Role of prostaglandin E2 receptor 4 in cardiovascular diseases.
Sai-Lun WANG ; Jia-Wei LU ; You-Fei GUAN ; Xiao-Yan ZHANG ; Hu XU
Acta Physiologica Sinica 2019;71(2):361-370
Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.
Cardiovascular Diseases
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physiopathology
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Cyclooxygenase 2
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Dinoprostone
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physiology
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Humans
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Receptors, Prostaglandin E, EP4 Subtype
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physiology