1.Pneumonia Caused by Adenovirus Genotype 55 in an Army Recruit Training Center.
Jin Gu YOON ; Saem Na LEE ; Jung Min LEE ; Ji Yun NOH ; Joon Young SONG ; Hee Jin CHEONG ; Woo Joo KIM
Korean Journal of Medicine 2016;90(4):365-368
Adenoviral pneumonia is rare in healthy adults. However, several cases were recently reported in a military training center in South Korea. Adenovirus genotype 3, 6, and 7 are predominant in South Korea. More recently, genotype 55, which emerged sporadically in China, has been reported in South Korea. In this study, we present a case of adenoviral pneumonia caused by genotype 55 in a healthy soldier from an army recruit training center in South Korea.
Adenoviridae*
;
Adult
;
China
;
Genotype*
;
Humans
;
Korea
;
Military Personnel
;
Pneumonia*
2.Fatal Hemophagocytic Lymphohistiocytosis associated with Influenza B.
Saem Na LEE ; Jin Gu YOON ; Chi Hyun CHO ; Chul Won CHOI ; Jung Yoon CHOI ; Hee Jin CHEONG ; Woo Joo KIM
Korean Journal of Medicine 2016;91(1):88-91
Influenza infection may be complicated by various infectious or non-infectious diseases. Among them, hemophagocytic lympho-histiocytosis (HLH) is an uncommon hyperinflammatory syndrome caused by uncontrolled proliferation and activation of macrophages and lymphocytes, and it is often life threatening. A previously healthy male patient was suspected to have HLH after influenza B infection. The diagnosis was established based on clinical diagnostic criteria suggested in the HLH-2004 trial. Despite prompt antiviral therapy, the patient expired on day 19 of hospitalization. Influenza can thus be complicated by HLH. Due to the non-specific manifestations of HLH, clinical suspicion and early diagnosis are important.
Diagnosis
;
Early Diagnosis
;
Hospitalization
;
Humans
;
Influenza, Human*
;
Lymphocytes
;
Lymphohistiocytosis, Hemophagocytic*
;
Macrophages
;
Male
3.Perception and Attitudes of Korean Obstetricians about Maternal Influenza Vaccination.
Ji Yun NOH ; Yu Bin SEO ; Joon Young SONG ; Won Suk CHOI ; Jacob LEE ; Eunju JUNG ; Seonghui KANG ; Min Joo CHOI ; Jiho JUN ; Jin Gu YOON ; Saem Na LEE ; Hakjun HYUN ; Jin Soo LEE ; Hojin CHEONG ; Hee Jin CHEONG ; Woo Joo KIM
Journal of Korean Medical Science 2016;31(7):1063-1068
Pregnant women are prioritized to receive influenza vaccination. However, the maternal influenza vaccination rate has been low in Korea. To identify potential barriers for the vaccination of pregnant women against influenza, a survey using a questionnaire on the perceptions and attitudes about maternal influenza vaccination was applied to Korean obstetricians between May and August of 2014. A total of 473 respondents participated in the survey. Most respondents (94.8%, 442/466) recognized that influenza vaccination was required for pregnant women. In addition, 92.8% (410/442) respondents knew that the incidence of adverse events following influenza vaccination is not different between pregnant and non-pregnant women. However, 26.5% (124/468) obstetricians strongly recommended influenza vaccination to pregnant women. The concern about adverse events following influenza vaccination was considered as a major barrier for the promotion of maternal influenza vaccination by healthcare providers. Providing professional information and education about maternal influenza vaccination will enhance the perception of obstetricians about influenza vaccination to pregnant women and will be helpful to improve maternal influenza vaccination coverage in Korea.
Asian Continental Ancestry Group
;
Cross-Sectional Studies
;
Female
;
*Health Knowledge, Attitudes, Practice
;
Humans
;
Influenza Vaccines/*immunology
;
Influenza, Human/*prevention & control
;
Maternal Welfare
;
*Perception
;
Physicians/*psychology
;
Pregnancy
;
Pregnant Women
;
Republic of Korea
;
Surveys and Questionnaires
;
Vaccination
4.Ca2 -activated K Currents of Pancreatic Duct Cells in Guinea-pig.
Han Wook LEE ; Jingchao LI ; Na Youn KOO ; Zheng Gen PIAO ; Sung Min HWANG ; Jae Woong HAN ; Han Saem CHOI ; Jong Heun LEE ; Joong Soo KIM ; Kyungpyo PARK
The Korean Journal of Physiology and Pharmacology 2004;8(6):335-338
There are numerous studies on transepithelial transports in duct cells including Cl and/or HCO3. However, studies on transepithelial K transport of normal duct cells in exocrine glands are scarce. In the present study, we examined the characteristics of K currents in single duct cells isolated from guinea pig pancreas, using a whole-cell patch clamp technique. Both Cl and K conductance were found with KCl rich pipette solutions. When the bath solution was changed to low Cl, reversal potentials shifted to the negative side, 75 4 mV, suggesting that this current is dominantly selective to K. We then characterized this outward rectifying K current and examined its Ca2 dependency. The K currents were activated by intracellular Ca2. 100 nM or 500 nM Ca2 in pipette significantly (P< 0.05) increased outward currents (currents were normalized, 76.8 7.9 pA, n=4 or 107.9 35.5 pA, n=6) at 100 mV membrane potential, compared to those with 0 nM Ca2 in pipette (27.8 3.7 pA, n=6). We next examined whether this K current, recorded with 100 nM Ca2 in pipette, was inhibited by various inhibitors, including Ba2, TEA and iberiotoxin. The currents were inhibited by 40.4 % (n=3), 87.0 % (n=5) and 82.5 % (n=9) by 1 mM Ba2, 5 mM TEA and 100 nM iberiotoxin, respectively. Particularly, an almost complete inhibition of the current by 100 nM iberiotoxin further confirmed that this current was activated by intracellular Ca2. The K current may play a role in secretory process, since recycling of K is critical for the initiation and sustaining of Cl or HCO3 secretion in these cells.
Animals
;
Baths
;
Exocrine Glands
;
Guinea Pigs
;
Membrane Potentials
;
Pancreas
;
Pancreatic Ducts*
;
Recycling
;
Secretory Pathway
;
Tea
5.Campylobacter jejuni Bacteremia in a Liver Cirrhosis Patient and Review of Literature: A Case Study.
Jin Gu YOON ; Saem Na LEE ; Hak Jun HYUN ; Min Joo CHOI ; Ji Ho JEON ; Eunju JUNG ; Seonghui KANG ; Jeeyong KIM ; Ji Yun NOH ; Won Suk CHOI ; Joon Young SONG ; Hee Jin CHEONG ; Woo Joo KIM
Infection and Chemotherapy 2017;49(3):230-235
Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities.
Abdominal Pain
;
Asian Continental Ancestry Group
;
Bacteremia*
;
Campylobacter Infections
;
Campylobacter jejuni*
;
Campylobacter*
;
Cefotaxime
;
Diarrhea
;
Fever
;
Humans
;
Immunocompromised Host
;
Liver Cirrhosis*
;
Liver*
6.Viral Shedding and Environmental Cleaning in Middle East Respiratory Syndrome Coronavirus Infection.
Joon Young SONG ; Hee Jin CHEONG ; Min Joo CHOI ; Ji Ho JEON ; Seong Hee KANG ; Eun Ju JEONG ; Jin Gu YOON ; Saem Na LEE ; Sung Ran KIM ; Ji Yun NOH ; Woo Joo KIM
Infection and Chemotherapy 2015;47(4):252-255
Viral shedding lasted 31 and 19 days from symptom onset in two patients with east respiratory syndrome coronavirus (MERS-CoV) pneumonia, respectively. Environmental real-time RT-PCR was weakly positive for bed guardrail and monitors. Even after cleaning the monitors with 70% alcohol-based disinfectant, RT-PCR was still weakly positive, and converted to negative only after wiping with diluted sodium chlorite. Further studies are required to clarify the appropriate methods to clean environments during and after treatment of patients with MERS-CoV infection.
Coronavirus Infections*
;
Coronavirus*
;
Humans
;
Middle East*
;
Pneumonia
;
Sodium
;
Virus Shedding*
7.Effects of the C3G/D3G anthocyanins-rich black soybean testa extracts on improvement of lipid profiles in STZ-induced diabetic rats.
So Young PARK ; Sujeong PAK ; Song Joo KANG ; Na Young KIM ; Da Saem KIM ; Min Jin KIM ; Seon Ah KIM ; Ji Young KIM ; So Yeon PARK ; So Hyun PARK ; Cho Rong YOUN ; Bo Ram LEE ; Hyo Eun LEE ; So Young CHOI ; Hee Won CHOI ; Jin Yeo HEO ; A Yeong HWANG ; Myoung Sook LEE
Journal of Nutrition and Health 2015;48(4):299-309
PURPOSE: The purpose of this study was to examine the effect of black soybean (CJ-3) testa extracts on lipid profiles in streptozotocin (STZ)-induced diabetic rats. METHODS: One control group and four STZ-induced diabetic groups with different doses of black soybean (CJ-3) testa extracts treatment [0 mg/kg (diabetic control, EX), 250 mg/kg (EX-250), 500 mg/kg (EX-500), 1,000 mg/kg (EX-1000)] were orally administered for 4 weeks. RESULTS: All CJ-3 treatment groups had remarkably lower serum triglyceride (TG) levels than that of EX group (p < 0.05) whereas hepatic TG contents did not show any differences. Results from serum total cholesterol (TC) concentrations of EX-250 and EX-1000 groups were decreased compared to EX group (p < 0.05). Furthermore, protein levels of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase from the liver decreased in all treatment groups (p < 0.05). However, significant differences were not observed in serum glucose and insulin, and glucose transporter 4 (GLUT-4) protein expression in skeletal muscle tissue. CONCLUSION: These results suggest that black soybean testa extracts could be useful for improvement of hyperlipidemia and hypercholesteremia in diabetes.
Animals
;
Anthocyanins
;
Blood Glucose
;
Cholesterol
;
Glucose Transport Proteins, Facilitative
;
Hypercholesterolemia
;
Hyperlipidemias
;
Insulin
;
Liver
;
Muscle, Skeletal
;
Oxidoreductases
;
Rats*
;
Soybeans*
;
Streptozocin
;
Triglycerides