Background: This study was carried out on Iranian female adolescents to understandhealth needs for the purpose of designing health promoting intervention in schools.Methods: In this exploratory qualitative study, two focus group discussion (15 teachers)and 30 individual in-depth interviews were conducted among female adolescents in the eighthgrade in Zahedan, Iran. Qualitative content analysis was used for data evaluation.Results: The views of students and teachers demonstrated nine of needs including:informing students about the schools’ health project aims, education and training all dimensionsof health with an emphasis on mental health, use of experts in various fields for education fromother organisations, employing capable and trusted counselors in schools, utilisation of a varietyof teaching methods, activating reward systems for encouraging students’ participation in groupactivities, teaching communication and the ability to establish good relationships with parents andstrategies for resolving family conflict, teaching parents and students high-risk behaviours andstrategies for handling them as well as reforming wrong attitudes and indigenous sub-culture.Conclusion: This study found the different needs of Iranian female students comparedto other cultures about a health promoting school programme. Therefore, their contribution canprovide an insight for formulating policies and intervention in schools.