No Abstract Available.
Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Polymerase Chain Reaction*

No Abstract Available.
Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Humans ; Polymerase Chain Reaction*

No abstract available.
Adult* ; Electrodes* ; Humans ; Neural Conduction*

Purpose: This study aimed to determine the current state of interventions for abused children and theireffectiveness by using a systemic review. Methods: Published intervention studies were identified through MEDLINE, Embase, CINAHL, DBpia, RISS,and Kiss DB. Eligible studies included articles published between 2009 and 2019 in English and Korean. Results: A total of 28 studies were selected for this review. The intervention elements of 28 selected studieswere categorized into 4 themes. The extracted intervention elements were divided into the themes of patient& situation-specific intervention, strengthen parent-child coping capacity and interaction, applyinggroup intervention and integrated intervention, Linkage with community resource and multidisciplinaryapproach. Conclusions The results demonstrate that social and psychological health of abused children has positivelychanged through these interventions. Therefore, it is important to implement treatment through active interventionaimed at helping the affected children.

No Abstract Available.
Histidine*

No Abstract Available.
Histidine*

The most critical aspect of full-arch prosthodontic treatment is evaluating whether the patient’s vertical occlusal dimension is appropriate, and if necessary, restoring it through increasing vertical dimension. If the vertical occlusal dimension is too low, it can lead to reduced chewing efficiency, as well as not only aesthetic concerns but also potential issues like hyperactivity of muscles and posterior displacement of the mandible. This report is about the patient dissatisfied with pronunciation and aesthetics due to an inappropriate vertical occlusal dimension resulting from prior prosthetic interventions, underwent full-arch prosthodontic restoration treatment. Through the utilization of digital diagnostic apparatus, a comprehensive evaluation was undertaken for patient’s vertical occlusal dimension, occlusal plane orientation, and the condition of prosthetic restorations. Through 3D facial scanning, the facial landmarks were discerned, and subsequently, the new occlusal plane was established. This provided the foundation for a digitally guided diagnostic wax-up. An elevation of 5 mm from the incisor was determined. Comprehensive dental rehabilitation was then executed for all remaining teeth, excluding the maxillary four incisors. The treatment protocol followed a systematic approach by initially creating implant-supported restorations on both sides of the dental arch to establish a stable occlusal contact. Subsequently, prosthetic restorations for the natural dentition were generated.Diagnostic and treatment planning were established through the utilization of facial scanning. This subsequently led to a reduction in treatment complexity and an expedited treatment timeline.

No abstract available.
Pregnancy* ; Purpura*

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently, it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.
Bone Morphogenetic Proteins ; Cell Differentiation ; Clonal Evolution ; Enteroendocrine Cells ; Epidermal Growth Factor ; Epithelium ; Hedgehogs ; Humans ; Neck ; Neoplasm Metastasis ; Neoplastic Stem Cells ; Nuclear Family ; Stem Cells ; Stomach ; Stomach Neoplasms

Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
Active Transport, Cell Nucleus* ; Carcinogenesis ; Cell Physiological Processes ; Cytoplasm ; Gene Expression ; Karyopherins ; Nuclear Localization Signals ; Nuclear Pore ; Nuclear Pore Complex Proteins ; Signal Transduction ; Transportation