1.Treatment of deep thrombosis.
Ok Bo WANG ; Won Gon KIM ; Kyu Seog CHO ; Joo Cheol PARK ; Sae Young YOU
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(11):1358-1361
No abstract available.
Thrombosis*
2.Treatment of the spontaneous pneumothorax by the vertical axillary thoracotomy.
Ok Bo WANG ; Won Gon KIM ; Kyu Seog CHO ; Joo Cheol PARK ; Sae Young YOU
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(11):1282-1285
No abstract available.
Pneumothorax*
;
Thoracotomy*
3.In Silico Screening for Angiogenesis-Related Genes in Rat Astrocytes.
Soo Young KIM ; Sae Won LEE ; Sung Yong YOU ; Sun Young RHA ; Kyu Won KIM
Genomics & Informatics 2004;2(1):36-44
Astrocytes play supportive roles for neurons in the brain. Recently, they have been accepted to have various functions in the vascular system as well as in the nervous system. We investigated the differential gene expression in rat astrocytes according to the oxygen tension, which is a crucial factor for angiogenesis. A cDNA microarray was performed to find the genes whose expression was sensitive to oxygen tension. We found 26 genes in the astrocyte were found and classified into 4 groups. In order to show the genes' relevancy to angiogenesis, seven of the 26 genes were investigated to see whether they have capabilities of interaction with angiogenesis-related factors in AngioDB. Through this investigation, we found interactions of three proteins with angiogenesis-related factors. These genes were further investigated with a new focus on the vascular endothelial growth factor (VEGF) expression in an astrocyte based on our hypothesis that astrocytes can have effects on endothelial angiogenesis via the release of VEGF. Collectively, we identified several genes whose expressions were dependent on the oxygen concentration of the astrocyte. Furthermore, the relevancy of astrocytes to angiogenesis was investigated using preexisting information of AngioDB, and suggested a possible signaling pathway for VEGF expression in the aspects of brain endothelial angiogenesis by astrocytes.
Animals
;
Astrocytes*
;
Brain
;
Computer Simulation*
;
Gene Expression
;
Mass Screening*
;
Nervous System
;
Neurons
;
Oligonucleotide Array Sequence Analysis
;
Oxygen
;
Rats*
;
Vascular Endothelial Growth Factor A
4.Simple Total Laparoscopic Hysterectomy: A clinical Evaluation of 312 Cases.
You Shin KIM ; Hong Seok LEE ; So Young KWON ; Mina EUN ; Kyung Sool LEE ; Young Sae PARK ; Chang Jo CHUNG ; In Hyeun KIM ; Jeong Ro LEE
Korean Journal of Obstetrics and Gynecology 2004;47(1):10-15
OBJECTIVE: This study was conducted to evaluate the clinical efficacy of simple total laparoscopic hysterectomy in the aspect of operation indication, operation time, hospitalization day, blood loss, and postoperative complications. METHODS: A retrospective evaluation for 312 women who undergone simplified total laparoscopic hysterectomy from January, 2002 to June, 2003 was done. RESULTS: The mean age of patients was 45.2 years, mean parity was 2.2, and mean uterine weight was 272.3 gm. The most common surgical indication was uterine myoma in 136 cases (43.5%), followed by adenomyosis in 90 cases (28.8%), myoma combined with adenomyosis in 52 cases (16.6%), uterine prolapse in 15 cases (4.8%), and HSIL 19 cases (6%) respectively. The most common concomitant operation was salpingooophorectomy in 53 cases (16.9%), followed by adhesiolysis in 40 cases (12.8%), colporraphy in 14 cases (4.4%), electrocauterization (ovary) in 4 cases (1.3%), pelvic floor suspension in 4 cases (1.3%), and TVT in 1 case (0.3%). The mean operation time was 107 minutes, and the average hospital day was 5.2 days. The preoperative and postoperative hemoglobin difference was 1.2 gm/dL. The complications of STLH were ureteral injury in 2 cases, intestinal injury in 1 case, and stump bleeding in 1 case. CONCLUSION: The most important factors for successful STLH were sufficiently trained laparoscopic team and the degree of pelvic adhesion. The most potential advantages of STLH are shorter duration of operation time, hospitalization, and less postoperative complications and more cost effectiveness. Therefore, STLH can be a new alternative option for hysterectomy and may replace the other methods of hysterectomy such as abdominal, vaginal and laparoscopic assisted vaginal hysterectomy (LAVH).
Adenomyosis
;
Cost-Benefit Analysis
;
Female
;
Hemorrhage
;
Hospitalization
;
Humans
;
Hysterectomy*
;
Hysterectomy, Vaginal
;
Leiomyoma
;
Myoma
;
Parity
;
Pelvic Floor
;
Postoperative Complications
;
Retrospective Studies
;
Ureter
;
Uterine Prolapse
5.Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women
Sunwha PARK ; Young-Ah YOU ; Hayoung YUN ; Suk-Joo CHOI ; Han-Sung HWANG ; Sae-Kyung CHOI ; Seung Mi LEE ; Young Ju KIM
Obstetrics & Gynecology Science 2020;63(4):455-463
Objective:
Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB).
Methods:
A multi-center prospective cohort study was conducted on 59 singleton pregnant women hospitalized for preterm labor (PTL) and/or preterm premature rupture of membranes (pPROM) between 22 weeks and 36 weeks 6 days of gestation from 2014 to 2015. The levels of 13 inflammatory cytokines (macrophage inflammatory protein [MIP]-1α, MIP-1β, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-8, IL-17α, granulocyte colony stimulating factor [G-CSF], IL-7, IL-4, IL-5, IL-10, and IL-13) were measured using a multiplex bead-based immunoassay and that of fetal fibronectin (fFN) was measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using Student’s t-test, Mann-Whitney U test, Pearson’s correlation, and receiver operating characteristic (ROC) curve analysis in SPSS version 20.0.
Results:
Among the 13 cytokines assessed, the levels of 3 cytokines (MIP-1α, IL-6, and IL-7) were negatively correlated with gestational age at delivery (P=0.028, P=0.002, and P=0.018, respectively). Sensitivities of MIP-1α, IL-6, and IL-17α were 70%, 80%, and 75%, respectively, and their specificities were 57%, 65%, and 69%, respectively. The sensitivity and specificity of fFN were 33% and 95%, respectively.
Conclusion
In symptomatic women diagnosed with PTL and/or pPROM, cytokines from cervicovaginal fluid, especially IL-6 and IL-17α, could be better predictive markers of PTB than fFN.
6.Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women
Sunwha PARK ; Young-Ah YOU ; Hayoung YUN ; Suk-Joo CHOI ; Han-Sung HWANG ; Sae-Kyung CHOI ; Seung Mi LEE ; Young Ju KIM
Obstetrics & Gynecology Science 2020;63(4):455-463
Objective:
Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB).
Methods:
A multi-center prospective cohort study was conducted on 59 singleton pregnant women hospitalized for preterm labor (PTL) and/or preterm premature rupture of membranes (pPROM) between 22 weeks and 36 weeks 6 days of gestation from 2014 to 2015. The levels of 13 inflammatory cytokines (macrophage inflammatory protein [MIP]-1α, MIP-1β, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-8, IL-17α, granulocyte colony stimulating factor [G-CSF], IL-7, IL-4, IL-5, IL-10, and IL-13) were measured using a multiplex bead-based immunoassay and that of fetal fibronectin (fFN) was measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using Student’s t-test, Mann-Whitney U test, Pearson’s correlation, and receiver operating characteristic (ROC) curve analysis in SPSS version 20.0.
Results:
Among the 13 cytokines assessed, the levels of 3 cytokines (MIP-1α, IL-6, and IL-7) were negatively correlated with gestational age at delivery (P=0.028, P=0.002, and P=0.018, respectively). Sensitivities of MIP-1α, IL-6, and IL-17α were 70%, 80%, and 75%, respectively, and their specificities were 57%, 65%, and 69%, respectively. The sensitivity and specificity of fFN were 33% and 95%, respectively.
Conclusion
In symptomatic women diagnosed with PTL and/or pPROM, cytokines from cervicovaginal fluid, especially IL-6 and IL-17α, could be better predictive markers of PTB than fFN.
7.Chinese Bellflower Root Anaphylaxis: IgE-Binding Components and Cross-Reactivity With Mugwort and Birch.
Sae Hoon KIM ; Sang Min LEE ; Heung Woo PARK ; Sang Heon CHO ; Kyung Up MIN ; You Young KIM ; Yoon Seok CHANG
The Korean Journal of Internal Medicine 2009;24(3):279-282
A 56-year-old man who had suffered from seasonal rhinitis in spring and autumn experienced recurrent generalized urticaria and an oral burning sensation after eating several cooked herbs for 3 months. A skin-prick test showed positive responses to various pollens, celery, Chinese bellflower, and arrowroot. The Chinese bellflower-specific IgE ELISA OD value was 1.547. Oral challenge with unprocessed raw Chinese bellflower root provoked oral burning sensation, eyelid swelling, generalized urticaria, and hypotension. In an ELISA inhibition test, IgE binding to Chinese bellflower was significantly inhibited by Chinese bellflower, mugwort, and birch pollen extract. SDS-PAGE and immunoblot assay revealed nine IgE-binding components, and common protein bands were detected in the range of 40~55 kDa (Chinese bellflower-mugwort-birch) and 14 kDa (Chinese bellflower-birch). Chinese bellflower root can cause anaphylaxis and may have cross-reactivity with mugwort and birch.
Anaphylaxis/*etiology
;
Artemisia/*immunology
;
Betula/*immunology
;
Cross Reactions
;
Humans
;
Immunoglobulin E/*immunology
;
Male
;
Middle Aged
;
Platycodon/*immunology
9.Two Cases of H2-Receptor Antagonist Hypersensitivity and Cross-Reactivity.
Woo Jung SONG ; Min Hye KIM ; Sang Min LEE ; Yong Eun KWON ; Sae Hoon KIM ; Sang Heon CHO ; Kyung Up MIN ; You Young KIM ; Yoon Seok CHANG
Allergy, Asthma & Immunology Research 2011;3(2):128-131
H2-receptor antagonists, such as cimetidine, ranitidine and famotidine, are some of the most commonly prescribed medications for gastric acid-related disorders. These compounds are generally well-tolerated and anaphylactic reactions to them are rare. Here, we report two cases of H2-receptor antagonist-induced anaphylactic reactions: the first presented with sudden dyspnea, sneezing, urticaria, and swelling of the eyelids after ranitidine intake. The second presented with sudden severe urticaria, facial swelling, chest discomfort, dizziness, and hypotension. Possible cross-reactivity with other H2-receptor antagonists was assessed by oral challenge and skin tests. To date, only a few reports addressing cross-reactivity among H2-receptor antagonists have been published. We review the literature and summarize the data available on drug cross-reactivity in H2-receptor antagonist hypersensitivity.
Anaphylaxis
;
Cimetidine
;
Cross Reactions
;
Dizziness
;
Drug Hypersensitivity
;
Dyspnea
;
Eyelids
;
Famotidine
;
Histamine H2 Antagonists
;
Hypersensitivity
;
Hypotension
;
Ranitidine
;
Skin Tests
;
Sneezing
;
Thorax
;
Urticaria
10.The Current Practice of Skin Testing for Antibiotics in Korean Hospitals.
So Hee LEE ; Heung Woo PARK ; Sae Hoon KIM ; Yoon Seok CHANG ; Sun Sin KIM ; Sang Heon CHO ; Kyung Up MIN ; You Young KIM
The Korean Journal of Internal Medicine 2010;25(2):207-212
BACKGROUND/AIMS: Antibiotic skin testing is a useful procedure for identifying patients with IgE-mediated hypersensitivity to antibiotics. The procedures, however, have not been standardized, and the testing is performed with diverse protocols in Korean hospitals wards. Thus, we examined the current practice of antibiotic skin testing in Korea. METHODS: We sent questionnaires to 12 allergists working in secondary or tertiary referral hospitals and collected them by e-mail or fax. The questionnaire included items such as the types and concentrations of the tested antibiotics, the methods of antibiotic skin testing, and the interpretation of the results. RESULTS: All hospitals responded to the questionnaire. The antibiotic skin testing protocols were variable, inconsistent, and differed with regard to the type and concentrations of antibiotics, the volume injected, and the interpretation of the results. Moreover, the protocols differed from the commonly recommended procedures in the medical literature. CONCLUSIONS: Standardized guidelines for antibiotic skin testing are needed for the safe and effective use of antibiotics in Korea.
Allergy and Immunology/*statistics & numerical data
;
Anti-Bacterial Agents/*adverse effects
;
Drug Hypersensitivity/*diagnosis
;
*Health Care Surveys
;
Humans
;
Medical Staff, Hospital/statistics & numerical data
;
Professional Practice/statistics & numerical data
;
Questionnaires
;
Republic of Korea
;
Skin Tests/*utilization