No abstract available.
Humans ; Renal Insufficiency*

No abstract available.

No abstract available.

We illustrate serial HRCT findings over a 16-month period in a 35-year-old woman who had ingested paraquat. Initial areas of ground-glass opacity changed into areas of multiple air cysts on follow up scan obtained five months after ingestion. A further follow-up scan obtained 16 months after ingestion showed improvement, with increased lung volume and normalized lung architecture.
Adult ; Eating ; Female ; Follow-Up Studies* ; Humans ; Lung ; Paraquat

We illustrate serial HRCT findings over a 16-month period in a 35-year-old woman who had ingested paraquat. Initial areas of ground-glass opacity changed into areas of multiple air cysts on follow up scan obtained five months after ingestion. A further follow-up scan obtained 16 months after ingestion showed improvement, with increased lung volume and normalized lung architecture.
Adult ; Eating ; Female ; Follow-Up Studies* ; Humans ; Lung ; Paraquat

BACKGROUND: The Multiplate analyzer (Dynabyte GmbH) has been recently introduced as a platelet function test for patients taking antiplatelet drugs. The study aimed at providing basic data for determining the reference interval of parameters produced by Multiplate in Koreans and to study the factors that influence those parameters. METHODS: Blood was collected from 35 healthy volunteers (female 18, male 17) into tubes containing hirudin or 3.2% sodium citrate. Whole blood platelet aggregations triggered by adenosine-5'-diphosphate (ADP), ADP-high sensitive (ADP+PGE1 only in hirudin samples), arachidonic acid (AA), collagen or thrombin receptor activator peptide (TRAP) were investigated using Multiplate according to the manufacturer's instructions. Data from healthy volunteers for the area under the curve (AUC) were determined from the central 95th percentile of the results. RESULTS: The values of AUC in hirudin samples for all agonists were significantly higher than those in sodium citrate samples. The AUC values in hirudin (sodium citrate) samples were as follows: ADP 38-107 (18-119) U; ADP+PGE1 16-91 U; AA 64-156 (32-117) U; collagen 53-112 (26-108) U; and TRAP 81-163 (49-149) U. The parameters from Multiplate were significantly correlated with leukocyte counts, but not with hematocrit levels. CONCLUSIONS: Although our data were derived from only 35 subjects, the results are expected to be helpful in determining the reference interval at a single institute and may serve as basic data for future cumulative data of reference intervals from multiple institutes in Korea.
Academies and Institutes ; Adenosine Diphosphate ; Arachidonic Acid ; Area Under Curve ; Blood Platelets ; Citrates ; Citric Acid ; Collagen ; Hematocrit ; Hirudins ; Humans ; Korea ; Leukocyte Count ; Male ; Platelet Aggregation Inhibitors ; Platelet Function Tests ; Receptors, Thrombin ; Sodium

BACKGROUND: The central physiological derangement of hemorrhagic fever with renal syndrome (HFRS) caused by hantaan virus (HTNV) is a vascular dysfunction, manifested by hemorrhage, impaired vascular tone and increased vascular permeability. Platelet activating factor (PAF), whose actions are mediated through a specific receptor, is a potent bioactive lipid. PAF has diverse biological functions in the vascular system, such as increasing vascular permeability, adhesion of leukocytes to the endothelium and reduction of cardiac output, which result in hypotension and shock. The goal of the present study was to investigate whether PAF is involved in the pathogenesis of HFRS. For this purpose, we evaluated the effect of HTNV on the expression of PAF receptor (PAF-R) and on the activity of PAF-acetylhydrolase (PAF-AH) instead of PAF because PAF is rapidly degraded by PAF-AH in vivo. MATERIALS AND METHODS: To evaluate the expression of PAF-R, we performed reverse-transcription PCR, western blot and FACS analyses using HTNV-infected human umbilical vein endothelial cells (HUVECs) and non-infected (control) HUVECs. In addition, we measured the activity of plasma PAF-AH in HFRS patients and normal healthy persons. RESULTS: The mRNA and protein expression of PAF-R was increased in HTNV-infected HUVECs compared with control HUVECs at 2 and 3 days post-infection (d.p.i.). FACS analysis showed that HTNV induced the surface expression of PAF-R in HUVECs from 2 d.p.i. The activity of plasma PAF-AH was 2.5-fold lower in HFRS patients than in normal healthy persons. CONCLUSION: Increased PAF-R expression by HTNV might increase the responsiveness to PAF in endothelial cells. Reduced PAF-AH activity in the blood of HFRS patients might delay PAF degradation. These results suggest that changes in PAF-R and PAF-AH by HTNV might influence to PAF activity and might be involved in the vascular dysfunction of HFRS.
Blood Platelets ; Blotting, Western ; Capillary Permeability ; Cardiac Output ; Endothelial Cells ; Endothelium ; Hantaan virus ; Hemorrhage ; Hemorrhagic Fever with Renal Syndrome ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypotension ; Leukocytes ; Plasma ; Platelet Activating Factor ; Platelet Membrane Glycoproteins ; Polymerase Chain Reaction ; Receptors, G-Protein-Coupled ; RNA, Messenger ; Shock

Most common annoyant for angular blepharitis has long been known as a diplobacillus of Morax-Axenfeld since 1897. Bacteriological study has been done on 56 patients (102 eyes) being suffered from angular blepharitis clinically diagnosed in the Dept. of Ophthalmology, Yonsei University College of Medicine. Most angular blepharitis involved bilaterally (82%), 34 cases of angular blepharitis were seen in the nasal canthus (61%). Staphylococcus epidermidis was isolated from 50 eyes (49%) with angular blepharitis and staphylococcus au reus from 41 eyes (40%). No diplobacillus of Morax-Axenfeld was demonstrated in the culture from angular blepharitis.
Blepharitis* ; Humans ; Ophthalmology ; Staphylococcus ; Staphylococcus epidermidis

This study was planned to determine the subjective and objective refraction under Mydrin P (Sansei Do Pham. Co.) among 758 Korean high school girls in Seoul area age of 12 to 18 years. Brightness (illumination) of 6 class rooms out of 30 in junior high school and 11 class rooms out of 24 in senior high school was measured with a sight meter (Western model 703-60, type 7, Western Co.) and a sun light illumination meter (Western model 756, Weston Co.). 1. Among 758 high school girls, error was 80.34% and emmetropia 19.66%. 2. As to the distribution of refractive erros, 30.02% was hyperopic refractive error and 69.98% was myopic refractive error. 3. The incidence of each refractive errors was the following order: hyperopia 15.44%, myop4 37.40%, compound myopic astigmatism 15.04%, compound hyperopic astigmatism 5.54%, simple myopic astigmatism 3.23%, simple hyperopic astigmatism 2.9%, mixed astigmations 0.73%. 5. The incidence of refractive errors in relation to age reveals the myopic refractive error increases from 37.35% at the age of 12 years reaching to 97.06% at the age of 18 years, while the hyperopic refractive error decreases from 62.65% at the age of 12 years decreasing to 2.94% at the age of 18 years. 6. Emmetropia was most frequent at the age of 16 years and there after tends to decrease. 7. Hyperopic refractive error under 1.00D was 23.99% and myopic refractive error under 1.00D was 26.62%. 8. As to the type of astigmatism, "with the rule" was 52.88%, "against rule" 40.14%, "oblique" 4.33% and mixed astigmatism 2.64% only. 9. The brightness of classrooms reveals averaing 75.5 F.C. in senior high school and 30.2 F.C. in senior high school. The day light factor measured at the same time was average 6.2% in junior high school and 1.8% in senior high school. The balance of illumination measured at the sametime was average 69.8% in junior high school and 52.6% in senior high school.
Astigmatism ; Emmetropia ; Female ; Humans ; Hyperopia ; Incidence ; Lighting ; Refractive Errors ; Seoul ; Solar System

Increases in heart rate (HR) and blood pressure (BP) are common during light planes of anesthesia at the end of operation and just prior to extubation. This study was undertaken to investigate and compare HR and BP responses to endotracheal extubation during light general anesthesia with and without prior intravenous administration of clonidine. Eighty hypertensive patients aged 45-65 yr were undergoing a variety of operations. In this study, the BP of hypertensive patients was well controlled on antihypertensive regimens before anesthesia. Anesthesia was induced by the injection of thiopental sodium, diazepam, fentanyl and vecuronium, and maintained with enflurane (0.8-2.5 per cent) and nitrous oxide (50 per cent) in oxygen. Patients were randomly divided into two groups of 40 each with regard to management of endotracheal extubation at the end of operation. Patients in clonidine group received an izv injection of clonidine (0.75 ug/kg) 30 min. prior to extubation. One minute prior to extubation, baseline arterial BP and HR were recoreded. Single measurement of systolic and diastolic BP and HR were obtained during the study and were recorded at 30 seconds, 1 min., 2 min., 3 min., 4 min. and 5 min. after extubation, and upon entrance to the postanesthetic recovery room (6-10 min. after extubation). Patients in control group received no injection prior to extubation, but were otherwise treated similarly and had data recorded at the same times as those in clonidine group. The results were as follows ;1) No significant differences were noted in BP and HR prior to clonidine administration between patients in the two groups. 2) Thirty seconds after extubation, both BP and HR increased significantly in both group (p< 0.05) but the increasing rate in clonidine group was significantly less than in control group (p<0.05). 3) Patients in control and clonidine group sustained a significant elevation in both BP and HR which persisted for 3 and 1 min after extubation (p<0.05), respectively. 4) Changes in both BP and HR in patients of clonidine group became significantly less than control group every time intervals after extubation (p<0.05). In conclusion, the result of this study demonstrate that iv injection of clonidine (0.75 ug/kg) administered 30 min. before endotracheal extubation prevents increases in BP and HR before and after extubation and in the recovery room. The data suggest that iv clonidine injection prior to extubation should be of advantage to patients with hypertension who may not be able to tolerate the increased hemodynamics which usually accompany endotracheal extubation.
Administration, Intravenous ; Airway Extubation ; Anesthesia ; Anesthesia, General ; Blood Pressure ; Clonidine* ; Diazepam ; Enflurane ; Fentanyl ; Heart Rate ; Hemodynamics ; Humans ; Hypertension ; Nitrous Oxide ; Oxygen ; Recovery Room ; Thiopental ; Vecuronium Bromide