No abstract available.
Apoptosis* ; Prostate* ; Prostatic Hyperplasia* ; Prostatic Neoplasms* ; Proto-Oncogene Proteins c-myc*

1. Fifty one cases of fractures of the shaft of the femur in children, treated at Seoul National University Hospital during the seven years, from August 1962 to July 1969, were analyzed. 2. In thirty eight of the cases fracture involved the middle third of the shaft, in eleven the upper third, and in two the lower third. 3. Bryant traction was employed in fifteen of the cases ranging from four months to six years of age. One case, five years old, was complicated by Volkmanns ischemic contracture on both legs. 4. Russell traction was employed in eleven of the cases ranging from six to fourteen years of age. Angulation and distraction must be watched especially in the younger age group, although we encountered no serious complications which required subsequent treatment. 5. Hoke traction was employed in twelve of the cases ranging from six to eleven years of age. Although this form of treatment is not particularly popular, we are of the opinion that it is the treatment of choice over two years of age and,under six years of age and that between six and twelve years of age it may be optionally employed along with Russell traction. We found it. particularly useful and convenient in selected cases in which Russell traction could not be effectively employed. 6. In some of the complicated cases, open reduction and internal fixation, closed reduction with pin and plaster immobilization, or skeletal traction was employed.
Child ; Femur ; Humans ; Immobilization ; Ischemic Contracture ; Leg ; Seoul ; Traction

This is to present 44 cases of hip fractures, of these 28 being fractures of femoral neck and the remainder, intertrochanteric, which were treated at the Department of Orthopedic Surgery, Seoul National University Hospital for four years and 8 months from Jan. 1965 to Aug. 1969. 1. There were 33 males. and 11 females in the series. 26 cases(59.1) were over 51 years of age. 2. The femoral neck fractures were treated by means of Smith Petersen nailing in 16 cases, modified Girdlestone hip arthroplasty in 3 cases, Austin-Moore hip prosthesis in 6 cases and other methods in 3 cases. 3. Modified Girdlestone hip arthroplasty could be a treatment of choice for femoral neck fracture requiring hip arthroplasty for those unsuitable for extensive surgery. 4. The intertrochanteric fractures of femur except for 3 unstable fractures were treated successfully with the Smith-Petersen nail and plate, following anatomical reduction of fracture. In 3 unstable fractures, satisfactory stabilization and internal fixation was obtained by the method of medial displacement of proximal part of distal fragment of fracture.
Arthroplasty ; Clinical Study ; Female ; Femoral Neck Fractures ; Femur ; Femur Neck ; Hip Fractures ; Hip Prosthesis ; Hip ; Humans ; Male ; Methods ; Orthopedics ; Seoul

No abstract available.
Mediastinum*

Opacification of the gallbladder after parenteral administration of contrast material usually indicates diminished renal function but can occur with normal renal function. The authors recently experienced 13 cases of such vicarious excretion of contrast media. Among 13 patients. 9 patients had renal disease unilateral ureteral stone(n=3), staghorn calculi(n=2), acute renal failure from sepsis(n=1), renal contusion(n=2) and unilateral renal artery involvement by dissecting aortic aneurysm(n=1). Of these 9 patients, 3 patients showed abnormal serum creatinine levels at the time of presentation or shortly thereafter. In 6 patients, injection of a large amount of contrast media was possibly the additional cause of vicarius excretion. There was no detectable cause in the remaining 4 patients. Heterotopic excretion of contrast media is clearly a complex phenomenon, the reason for which it is difficult to establish with certainty in each individual case. Anyhow, vicarius excretion of contrast media occurs more frequently than previously thought, and it can occur not only with abnormal renal function but with normal function also.
Acute Kidney Injury ; Contrast Media ; Creatinine ; Gallbladder* ; Humans ; Renal Artery ; Ureter

Purpose: Although postural control assessment in patients with chronic ankle instability (CAI) has been thoroughly examined in the literature, few researchers have studied balance strategy in lateral ankle sprain (LAS) copers, who recover from LAS injury with no symptom progression. The purpose of this study was to investigate the difference in center of pressure (COP) variables during static and dynamic posture control among LAS copers, patients with CAI, and ankle healthy controls. Methods: This case-control study recruited 20 patients with CAI, 20 LAS copers, and 20 controls. All participants filled out Ankle Instability Instrument and Foot and Ankle Ability Measure questionnaire and performed single-leg static postural control and Star Excursion Balance Test (SEBT). Results: LAS copers showed less mediolateral COP range as compared to patients with CAI (p=0.001) and control (p=0.001) during static postural control. Furthermore, LAS copers have less anteroposterior COP standard deviation (SD) (p=0.034), range (p=0.009), velocity (p=0.013) than patients with CAI. Relative to patients with CAI, LAS copers had small mediolateral COP SD (p=0.022) and range (p=0.018) during the posteromedial direction of the SEBT.However, there was no significant difference in both mediolateral and anteroposterior COP variables during anterior and posterolateral directions of the SEBT (p≥ 0.05). Conclusion Based on these observed results, the authors conclude that greater postural control in LAS copers is one of the movement strategies to prevent recurrent LAS as a defense mechanism.

No abstract available.
Animals ; Apoptosis* ; Collagen* ; Insulin* ; Rats* ; Streptozocin*

BACKGROUND: We studied the antibiotic sensitivities to the causative microorganisms of acute simple urinary tract infection for recent 3 years. METHODS: We analyzed 112 microorganisms and their antibiotic sensitivities of the 104 patients who were admitted to or visited the Department of Urology, Catholic University St. Marys Hospital and had more than 10cfu/mL on urine culture from June 1996 to January 1999 retrospectively. RESULTS: The chance of gram negative and positive as causative microorganisms was 72.3% and 27.7% respectively. The most common pathogenic microorganisms were Escherichia coli (67.0%) followed by a-hemolytic streptococci, Entercoccus. In gram negative acute UTI, imipenem, sulperanzone showed relatively higher sensitivity, while cotrimoxazole, ampicillin showed relatively lower sensitivity. In gram positive, vancomycin, penicillin showed relatively higher sensitivity, while ampicillin, imipenem showed relatively lower sensitivity. CONCLUSIONS: We consider that gram negative microorganisms, especially E. coli, is the main cause of acute simple UTI. But, we should be concerned about the increase of gram positive organisms and other gram negative organisms besides E. coli. Regarding to the choice of adequate drug in the treatment of UTI, it is necessary to consider the change of pathologic microorganisms.
Ampicillin ; Escherichia coli ; Humans ; Imipenem ; Penicillins ; Retrospective Studies ; Trimethoprim, Sulfamethoxazole Drug Combination ; Urinary Tract Infections* ; Urinary Tract* ; Urology ; Vancomycin

Background:Eutropin is a recombinant human growth hormone preparation and has been used in patients with growth hormone deficiency. Short stature is a characteristic feature of Turner syndrome, which is caused by sexual chromosomal anomalies. Growth hormone therapy would increase growth velocity and increase the ultimate final height in patients with Turner syndrome. The purpose of this study was to evaluate the clinical effects and safety in patients with Turner syndrome with Eutropin treatment. Subjects and METHODS:60 patients with Turner syndrome,who were diagnosed by chromosome study,were treated with Eutropin 1IU/kg/week for 12 months and followed up every 3 month. The height and weight were evaluate at 0, 3, 6, 9, 12 months. A complete blood count, ESR, urinary analysis and chemistry studies were done every 3 month. IGF- I , T4, TSH & anti-GH antibody were measured at 6 months and 12 months. Chest X-ray was checked at 0, 6 ,12 months. RESULTS:60 patients were enrolled but 10 patients were lost or treated irregularly and excluded in the study of growth effect. but included all cases in safety analysis. At the onset of Eutropin therapy,their mean age was 10.8+/-2.9 years old(range 4.2- 14.9yr)and the height was 121.1+/-13.7cm(-3.1+/-0.9 SDS) and yearly growth velociy was 3.4+/-1.5cm. Their weight was 30.5+/-10.6kg and bone age 9.1+/-3.0 yrs. After Eutropin treatment, mean height was increased to 123.2+/-13.5cm at 3 months, 125.2+/-13.1cm at 6 months, 127.5+/-12.4cm at 9 months, 128.3+/-12.8cm at 12 months. Height velocity were increased to 8.3+/-3.1cm at 3 months, 8.1+/-2.6cm at 6 months, 7.6+/-1.9cm at 9 months and 7.1+/-1.9cm at 12 months(P<0.001). Height SDS at 0, 3, 6, 9, 12 months were -3.1+/-0.9, -2.9+/-1.0, -2.7+/-0.9, -2.7+/-0.9 respectively(P>0.001).Their bone age were 9.1+/-3.0yr, 9.6+/-2.9yr, 10.2+/-2.7yr before and 6 & 12 months after treatment respectively. HA/BA were 0.84+/-0.15, 0.87+/-0.13, 0.88+/-0.12 at before and 6 & 12 months after treatment respectively(P<0.05). Growth velocity of 4-8 yrs group was most prominent compared to other groups. Serum IGF- I concentration was increased from 167.4+/-85.8ng/ml to 368.4+/-158.1ng/ml at 6 months and 423.2+/-181.0ng/ml at 12 month(P<0.001) after treatment. No significant changes were observed in thyroid function, CBC, ESR, Blood chemistry and urinalysis. Anti-hGH antibody were positive in 2 patients, but these didnot attenualte the growth velocity. CONCLUSION: Treatment with Eutropin increased significantly height velocity in patients with Turner syndrome. No specific adverse events were observed during Eutropin therapy.
Blood Cell Count ; Chemistry ; Growth Hormone ; Human Growth Hormone ; Humans* ; Thorax ; Thyroid Gland ; Turner Syndrome* ; Urinalysis

BACKGROUND: The large hemodynamic response induced by laryngoscopy and endotracheal intubation may cause serious cerebral complications. This study was performed to evaluate the effects of intralaryngotracheal 10% lidocaine spray on hemodynamic responses to endotracheal intubation for patients with a cerebral aneurysm. METHODS: Sixty patients with a cerebral aneurysm were randomly divided into three groups by lidocaine administration methods before endotracheal intubation: Group 1 (Control, 2% lidocaine 1.5 mg/kg, intravenous injection); Group 2 (10% lidocaine 1 mg/kg, intralaryngotracheal spray); Group 3 (10% lidocaine 1.5 mg/kg, intralaryngotracheal spray). Anesthesia was induced intravenously with midazolam (0.02 mg/kg) and thiopental sodium (2 - 3 mg/kg), and then maintained with 50% nitrous oxide in oxygen and 1.0 vol% isoflurane. Blood pressure and heart rate were measured preinduction, before laryngoscopy, immediately after epiglottis elevation, immediately after intubation and 3 minutes after intubation. Data were compared and analyzed within and between groups. RESULTS: Immediately after intubation, the increase in blood pressure and heart rate were blunted significantly in the groups 2 and 3 compared to the intravenous lidocaine injection group (P < 0.01). However, there were no significant hemodynamic changes between groups 2 and 3. CONCLUSIONS: The elevation of blood pressure and heart rate after endotracheal intubation can be prevented by intralaryngotracheal spray of 1 mg/kg of 10% lidocaine 3 minutes before endotracheal intubation.
Anesthesia ; Blood Pressure* ; Epiglottis ; Heart Rate* ; Heart* ; Hemodynamics ; Humans ; Intracranial Aneurysm* ; Intubation ; Intubation, Intratracheal* ; Isoflurane ; Laryngoscopy ; Lidocaine* ; Midazolam ; Nitrous Oxide ; Oxygen ; Thiopental