Recent studies have shown that opiods can produce potent antinociceptive effects by interacting with opioid receptors in peripheral tissues. This study sougt to compare the effects of morphine with those of-bupivacaine administered intraarticularly upon pain after arthroscopic knee surgery. In a ramdomized manner, 60 healthy patients received either morphine(3 mg in 20 ml NaCl : n=20), bupivacaine(20 ml, 0.25% : n=20) intraarticularly at the completion of surgery, and others were not administered (n = 20) under general anesthesia after 1, 2, 4, 6, 12 and 24h of postoperative day, pain was assessed by a visual analogue pain scalps, time to first analgesic use were recorded. Pain scores were signicantly greater in the morphine group than two groups at 11. From 4th until the end of the study period, pain scores were significantly greater in the bupivaca.ne group than in the other two group. Anagesic requirements were significantly greater in the morphine group than two groups at 1h but were significantly greater in the bupivacaine group than in the other groups throughout the remainder of the study period. The results suggest that intraarticular morphine produces an analgesic effect of delayed onset but of remarkably long duration.
Anesthesia, General ; Bupivacaine* ; Humans ; Knee* ; Morphine* ; Receptors, Opioid ; Scalp

Postoperative brain damage is one of most serious complications of cardiopulmonary bypass (CPB). To prevent brain damage during CPB, adequate cerebral perfusion for cerebral oxygen demand should be maintained. This study monitored jugular venous oxyhemoglobin saturation (SjO₂), which reflects the overall balance of cerebral oxygen supply and demand, intermittently in 10 patients undergoing cardiac surgery. At the initiation of CPB, in spite of a significant decrease in mean arterial pressure, SjO₂ did not change, and it was stable during the hypothermic period of CPB. But a significan reduction in SjO₂ was observed during the rewarming period, and SjO₂ had an inverse linear correlation with esophageal temperature. Furthermore, the percent decrease of SjO₂ was related to rewarming speed. Therefore, therapeutic approaches for SjO₂ desaturation include slower rewarming, increasing cerebral blood flow, decreasing the cerebral metabolic rate for oxygen, increasing oxygen content, and increasing perfusion flow rate.
Arterial Pressure ; Brain ; Cardiopulmonary Bypass ; Cerebrovascular Circulation ; Humans ; Oxygen ; Oxyhemoglobins* ; Perfusion ; Rewarming ; Thoracic Surgery

Ischemia results when the decrease in tissue perfusion exceeds the tissues ability to increase an oxygen extraction from the blood. Brain edema has been defined as an abnormal accumulation of fluid within brain parenchyma associated with a volumetric enlargement of the brain tissue. In most instances, the labelling of edema as vasogenic or cytotoxic is only relative. For cerebral protection, there were many possible techniques which could increase or maintain cerebral perfusion and reduce cerebral metabolic demand for oxygen. This study was carried out the effect of mild
Brain Edema* ; Brain Ischemia* ; Brain* ; Edema ; Ischemia ; Oxygen ; Perfusion ; Tissues

Lidocaline if frequently administered as a component of an anesthetic : for local or regional nerve blocks, to mitigate the autonomic response to laryngoscopy and tracheal intubation, to suppress the cough reflex, and for antiarrythmic therapy. Diazepam dectease the potential central nervous system (CNS) toxicity of local anesthetic agents but -may modify the sitmulant action of lidocaine in addition to their own cardiovascular depressant. The potential cardiovascular toxicity of local anesthetics may be enhanced by the concomitant administration of diazepam. This study was designed to investigate the effects of lidocaine dose and pretreated diazepam to cardiovascular system and plasma concentration of lidocaine. Lidocaine in 100 mcg/kg/min, 200 mcg/kg/min, and 300 mcg/kg/min was given by sequential infusion to dogs anesthetized with halothane-nitrous oxide (Group I). And in group II, after diazepam pretreatment, lidocaine was infused by same way when lidocaine was administered in 100 mcg/kg/min, the low plasma levels (3.97+/-0.22-4.48+/-0.36 mcg/ml) caused a little reduction in cardiovascular hemodynamics. As administered in 200 mcg/kg/min, 300 mcg/kg/min, the higher plasma levels (7.50+/-0.66-11.83+/-0.59 mcg/ml) reduced mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), left ventricular stroke work index (LVSWI), and right ventricular stroke work index (PVSWI) and incresed pulmonary artery wedge pressure (PAWP), central venous pressure (CVP), systemic vascular resistance index (SVRI), but was assciated with little changes of heart rate (HR), mean pulmonary artery pressure (MPAP), and pulmonary vascular resistance index (PVM). When lidocaine with pretreated diazepam was administered in 100 mcg/kg/min, the low plasma level, the lower level than when only lidocaine administered. reduced MAP, but was not changed other cardiovascular hemodynamics. While lidocaine was infused in 200 mcg/kg/min, 300 mcg/kg/min in dogs pretreated diazepam, the higher plasma level (7.64+/-0.79-13.79+/-0.82 mcg/ml) was maintained and was associated with reduced CI, SI, LVSWI and incresed PAWP, CVP, SVRI but was a little changes of HR, MPAP, PVRI. After CaCl2 administeration, CI, SI, SVRI, LVSWI was recovered but PAWP, UP was rather incresed than recovered. The foregoing results demonstrate that pretreated diazepam imposes no additional burden on cardiovascular system when a infusion of large dose of lidocaine is given to dogs anesthetized with halothanenitrous oxide. But caution may be advised if the addition of lidocaine is indicated in subjects who have impared autonomic nervous system and who are in hypercarbic, hypoxic, or acidotic states.
Anesthetics ; Anesthetics, Local ; Animals ; Arterial Pressure ; Autonomic Nervous System ; Cardiovascular System* ; Central Nervous System ; Central Venous Pressure ; Cough ; Diazepam* ; Dogs* ; Heart Rate ; Hemodynamics ; Intubation ; Laryngoscopy ; Lidocaine* ; Nerve Block ; Plasma* ; Pulmonary Artery ; Pulmonary Wedge Pressure ; Reflex ; Stroke ; Vascular Resistance

BACKGROUND: The large hemodynamic response induced by laryngoscopy and endotracheal intubation may cause serious cerebral complications. This study was performed to evaluate the effects of intralaryngotracheal 10% lidocaine spray on hemodynamic responses to endotracheal intubation for patients with a cerebral aneurysm. METHODS: Sixty patients with a cerebral aneurysm were randomly divided into three groups by lidocaine administration methods before endotracheal intubation: Group 1 (Control, 2% lidocaine 1.5 mg/kg, intravenous injection); Group 2 (10% lidocaine 1 mg/kg, intralaryngotracheal spray); Group 3 (10% lidocaine 1.5 mg/kg, intralaryngotracheal spray). Anesthesia was induced intravenously with midazolam (0.02 mg/kg) and thiopental sodium (2 - 3 mg/kg), and then maintained with 50% nitrous oxide in oxygen and 1.0 vol% isoflurane. Blood pressure and heart rate were measured preinduction, before laryngoscopy, immediately after epiglottis elevation, immediately after intubation and 3 minutes after intubation. Data were compared and analyzed within and between groups. RESULTS: Immediately after intubation, the increase in blood pressure and heart rate were blunted significantly in the groups 2 and 3 compared to the intravenous lidocaine injection group (P < 0.01). However, there were no significant hemodynamic changes between groups 2 and 3. CONCLUSIONS: The elevation of blood pressure and heart rate after endotracheal intubation can be prevented by intralaryngotracheal spray of 1 mg/kg of 10% lidocaine 3 minutes before endotracheal intubation.
Anesthesia ; Blood Pressure* ; Epiglottis ; Heart Rate* ; Heart* ; Hemodynamics ; Humans ; Intracranial Aneurysm* ; Intubation ; Intubation, Intratracheal* ; Isoflurane ; Laryngoscopy ; Lidocaine* ; Midazolam ; Nitrous Oxide ; Oxygen ; Thiopental

BACKGROUND: The effects of Trendelenburg positions used to expose the surgical field may induce intraoperative hemodynamic and respiratory changes that complicate anesthetic management. This study was performed to evaluate the effects of the lithotomy-Trendelenburg position on respiratory and hemodynamic changes with time passage during general anesthesia. METHODS: Twenty patients undergoing anorectal surgery with general anesthesia were studied. Hemodynamic and respiratory parameters were measured before the lithotomy-Trendelenburg position (L) and 3 min (LT3), 6 min (LT6), 12 min (LT12), 30 min (LT30) and 60 min (LT60) after the 30 degree Trendelenburg position. The cardiac index (CI), stroke volume (SV), systemic vascular resistance (SVR), airway resistance (Raw) and dynamic compliance (Cdyn) were measured by a non-invasive cardiac output monitor. RESULTS: Central venous pressure and peak inspiratory pressure were markedly increased from the lithotomy to the lithotomy-Trendelenburg position. Heart rate was slightly increased while SV, CI, SVR and MAP were decreased. No significant changes of the SV or CI were observed during surgery. The Cdyn was significantly decreased. CONCLUSIONS: The steep lithotomy-Trendelenburg position induces moderate adverse hemodynamic and respiratory effects in healthy patients. These findings indicate the need for more active hemodynamic and respiratory monitoring in patients with a compromised cardiopulmonary function.
Airway Resistance ; Anesthesia, General* ; Cardiac Output ; Central Venous Pressure ; Compliance ; Head-Down Tilt ; Heart Rate ; Hemodynamics* ; Humans ; Respiratory Mechanics ; Stroke Volume ; Vascular Resistance

Increases in heart rate (HR) and blood pressure (BP) are common during light planes of anesthesia at the end of operation and just prior to extubation. This study was undertaken to investigate and compare HR and BP responses to endotracheal extubation during light general anesthesia with and without prior intravenous administration of clonidine. Eighty hypertensive patients aged 45-65 yr were undergoing a variety of operations. In this study, the BP of hypertensive patients was well controlled on antihypertensive regimens before anesthesia. Anesthesia was induced by the injection of thiopental sodium, diazepam, fentanyl and vecuronium, and maintained with enflurane (0.8-2.5 per cent) and nitrous oxide (50 per cent) in oxygen. Patients were randomly divided into two groups of 40 each with regard to management of endotracheal extubation at the end of operation. Patients in clonidine group received an izv injection of clonidine (0.75 ug/kg) 30 min. prior to extubation. One minute prior to extubation, baseline arterial BP and HR were recoreded. Single measurement of systolic and diastolic BP and HR were obtained during the study and were recorded at 30 seconds, 1 min., 2 min., 3 min., 4 min. and 5 min. after extubation, and upon entrance to the postanesthetic recovery room (6-10 min. after extubation). Patients in control group received no injection prior to extubation, but were otherwise treated similarly and had data recorded at the same times as those in clonidine group. The results were as follows ;1) No significant differences were noted in BP and HR prior to clonidine administration between patients in the two groups. 2) Thirty seconds after extubation, both BP and HR increased significantly in both group (p< 0.05) but the increasing rate in clonidine group was significantly less than in control group (p<0.05). 3) Patients in control and clonidine group sustained a significant elevation in both BP and HR which persisted for 3 and 1 min after extubation (p<0.05), respectively. 4) Changes in both BP and HR in patients of clonidine group became significantly less than control group every time intervals after extubation (p<0.05). In conclusion, the result of this study demonstrate that iv injection of clonidine (0.75 ug/kg) administered 30 min. before endotracheal extubation prevents increases in BP and HR before and after extubation and in the recovery room. The data suggest that iv clonidine injection prior to extubation should be of advantage to patients with hypertension who may not be able to tolerate the increased hemodynamics which usually accompany endotracheal extubation.
Administration, Intravenous ; Airway Extubation ; Anesthesia ; Anesthesia, General ; Blood Pressure ; Clonidine* ; Diazepam ; Enflurane ; Fentanyl ; Heart Rate ; Hemodynamics ; Humans ; Hypertension ; Nitrous Oxide ; Oxygen ; Recovery Room ; Thiopental ; Vecuronium Bromide

OBJECTIVE: The purpose of this study was to determine the reliability and usefulness of the lateral femoral cutaneous nerve conduction study by comparing the modified Ma's method (method I) with the method proposed by Spevak and Prevec (method II) and to develop a standard value of the Korean normal adult by the method II. METHOD: Twenty-nine healthy adults were examined for the lateral femoral cutaneous nerve conduction by both methods bilaterally. The nerve was stimulated 1 cm medial to anterior superior iliac spine (ASIS) in the method I and 8 cm distal to ASIS in the method II. The sensory nerve action potential was recorded with 8 cm long strip electrodes placed on the thigh 17 cm distal to ASIS in the method I and 33 cm distal to ASIS in the method II. RESULTS: 1) Among 58 extremities, a sensory nerve action potential was detected in 52 extremities (89.7%) by the method I and in 57 extremities (98.3%) by the method II without a significant difference between both methods. 2) The mean distal latency was 3.41 msec by the method I and 4.56 msec by the method II. 3) The mean amplitude was 7.24 microvolt by the method I and 6.63 microvolt by the method II without a significant difference between both methods. 4) The mean conduction velocity was 50.9 m/sec by the method I and 55.2 m/sec by the method II without a significant difference between both methods. CONCLUSION: According to the study, both methods are compatible and reliable for the examination of lateral femoral cutaneous nerve except for a significant difference in a mean conduction velocity.
Action Potentials ; Adult ; Electrodes ; Extremities ; Humans ; Neural Conduction* ; Spine ; Thigh

BACKGROUND: We experienced unintentional hyperventilation during mechanical ventilation in pediatric general anesthesia. It is very difficult to decide respiratory rate or tidal volume with a patient's condition for adequate ventilation while respiratory gas monitoring is unavailable in many cases. Therefore, we studied to find a proper respiratory rate (RR) with a fixed tidal volume during mechanical ventilation in general anesthesia. METHODS: We studied 70 children weighing 10-30 kg during general anesthesia. An endotracheal tube was selected according to 3.5+age (yrs)/4. After intubation with midazolam, thiopental sodium and succinylcholine, mechanical ventilation was applied: tidal volume 8-10 ml/kg, peak inspiratory pressure 15-20 mmHg, RR 20 (infant), 18 (under 3 yrs), 16 (under 5 yrs), 14 (above 5 yrs) breaths/min. We adjusted the RR for a PetCO2 30 33 mmHg and arterial blood gas analysis was done 30 minutes each change. We calculated the RR for a PaCO2 of 36 mmHg according to the equation: RR (applied) = estimated RR estimated PaCO2/ideal PaCO2. In addition, the linear regression was analyzed between the age and RR. RESULTS: The estimated regression for RR using Pearson's correlation coefficient was as follows: RR = 19.25-0.07Xage (month). CONCLUSIONS: The equation (RR = 19.25-0.07Xage [month]) could be an index for safe ventilatory management without severe hyper- or hypo-carbia in the pediatric general anesthesia.
Anesthesia, General* ; Blood Gas Analysis ; Child ; Humans ; Hyperventilation ; Intubation ; Linear Models ; Midazolam ; Respiration, Artificial* ; Respiratory Rate* ; Succinylcholine ; Thiopental ; Tidal Volume ; Ventilation

BACKGROUND: Anesthesiologists should understand the physiology of intraocular pressure and the implications of anesthetic drugs and maneuvers on intraocular pressure(IOP). Although most anesthetics reduce IOP, succinylcholine causes a transient but significant increase in IOP. And thiopental by itself does not prevent to increase blood pressure, IOP. This study was designed to evaluate the preventive effect of propofol on IOP changes during tracheal intubation. METHODS: IOP was measured with a hand-held applanation tonometer in the eye. Baseline(control) IOP was measured before the induction of anesthesia(stage 1) and serial measurements of IOP were made after administration of the induction agent before intubation(stage 2), immediately after intubation(stage 3) and 10 minutes after intubation(stage 4). Heart rate and systolic blood pressure were recorded simultaneously. According to induction agent and neuromuscular blocker, the 60 patients were divided into control group(C; thiopental, succinylcholine), pretreatment group(T) using defasciculation dose of vecuronium bromide, propofol group(P; propofol, succinylcholine) and vecuronium group(V; propofol, vecuronium bromide). RESULTS: Administration of either propofol or thiopenal resulted in a significant reduction in IOP(P<0.01). At stage 2, IOP of gpoup P and V were significantly lower than that of group C(P<0.05). At stage 3, IOP increased significantly compared to the values of stage 1 in all group(P<0.01). At stage 4, IOP decreased significantly compared to the values of stage 1 in all group(P<0.01), but there was no significant difference between groups in IOP at stage 4. CONCLUSIONS: Propofol may be a useful induction agent of general anesthesia for opthalmic surgery, but cannot prevent to increase IOP during endotracheal intubation.
Anesthesia, General ; Anesthetics ; Blood Pressure ; Heart Rate ; Humans ; Intraocular Pressure* ; Intubation* ; Intubation, Intratracheal ; Neuromuscular Blockade ; Physiology ; Propofol* ; Succinylcholine ; Thiopental ; Vecuronium Bromide