Pedunculated hepatocellular carcinoma was first described by Roux in 1987, and Goldberg and Wallerstein presented a case with pathological description in 1934. Since then 37 cases have been reported in the world literature. A pedunculated hepatocellular carcinoma, occurred in a 69-year-old woman, was encountered. It was attached to the Glission's capsule of the right lobe of liver inferiorly, and was connected to the porta hepatis bt a mesenteric pedicle containing arteries, veins, bile ducts and nerve bundles. The tumor mass was completely encapsulated, and measured 8.5x8x6 cm and 255 gm. It was composed of hepatocellular carcinoma of a well-differentiated, acinar type. Tumor cells were positive for HBsAg, but negative for alpha-fetoprotein on peroxidase-antiperoxidase staining. The liver exhibited macronodular cirrhosis on gross examination. This tumor is thought to have on in the supernumerary lobe of liver.
Female ; Humans ; Carcinoma, Hepatocellular

A case of congenital diaphragmatic hernia in a newborn was presented, who had characteristic clinical and X-ray findings. The case manifested dyspnea, cyanosis and shift of the heart and mediastinum to the right immediately after birth, which was throught to be congenital diaphragmatic hernia and verified by autopsy. On autopsy, a large left diaphragmatic defect resulting massive diaphragmatic hernia and ipsilateral pulmonary hypoplasia were found. The authors report the case with review of pertinent literature.
Autopsy ; Cyanosis ; Dyspnea ; Heart ; Hernia, Diaphragmatic* ; Humans ; Infant, Newborn ; Lung* ; Mediastinum ; Parturition

No abstract available.
Nephrotic Syndrome*

We have experienced a 50-year-old male patient, who died of multiple metastatic nodular melanoma which had the primary lesions on the right hallux and forefoot with eventual involvement of skin and internal organs. An autopsy was performed for the evidence of metastatic features of the internal organs and their spreading routes, with concurrent histopathologic findings. The autopsy findings revealed diffuse metastases to the ipsilateral femoral and inguinal lymph nodes via ascending vascular channels and to the internal organs: 1. The heart had multiple metastatic lesions on the pericardium and right ventricular wall. And the mediastinal, periaortic and periesophageal lymph nodes were also involved. 2. The both lungs were moderately indurated and focally discolored, and showed metastatic lesions in the right lower lobe and hilar areas, Melanoma cells were diffusely invaded to the interstitia and alveoli. 3. The right 5th and 6th ribs showed the invsion of melanoma cells on their bone marrows, periostia, and Haversians canals. 4. The liver was enlarged and showed multiple various sized nodules on the surface with adesion to the parts of peritoneum, omentum and diaphragm. Melanoma cells were seen mostly on and around the sinusoidal spaces and parenchyma. 5. The stomach wall had an ulcerated metastatic lesion and the melanoma cells invaded deeply into the muscle layer. 6. The pancreas was normal in its size and shape but had multiple metastatic lesions on the head and body with melanoma celi infiltration. 7. The both kidneys were grar ular surfaced and showed two metastatic lesions on the right renal cortex and two on the left. Renal tubules and parenchyma were widely invaded by melanoma cells but the glomerular tufts were intact. 8. The adreral and thyroid glands showed four and two metastatic lesions respectively and diffuse invasion of melanoma cells into the parenchyma. 9. The brain was normal in gross appearance, but the cortex was edematous and showed settered melanoma cell infiltration.
Autopsy* ; Bone Marrow ; Brain ; Diaphragm ; Hallux ; Head ; Heart ; Humans ; Kidney ; Liver ; Lung ; Lymph Nodes ; Male ; Melanoma* ; Middle Aged ; Neoplasm Metastasis ; Omentum ; Pancreas ; Pericardium ; Peritoneum ; Ribs ; Skin ; Stomach ; Thyroid Gland ; Ulcer

No abstract available.
Colon* ; Dilatation* ; Humans ; Infant, Newborn*

A case of systemic mastocytosis in a 6 year old boy was presented. Skin lesions started to appear and spred several days after birth along with severe itching sensation, and intermitent abdominal pain & constipation developed at the age of 5. On physical examination, he was found to be underdeveloped (Height less than 3rd percentile) with normal vital signs. Liver was felt 1 1/2 fb below costal margin, spleen 2 fb. There were many brown to dark brown-colored irregular shaped maculopapulourticarial skin lesions, scattered all over the body, along with multiple thickened areas, and positive Darier's sign was noted. On upper GI series, many honey-combed filling defect were found throughout small intestine. Skin biopsy confirmed the diagnossis : showing multiple scattered infilteration of mast cells.
Abdominal Pain ; Biopsy ; Child ; Constipation ; Humans ; Intestine, Small ; Liver ; Male ; Mast Cells ; Mastocytosis, Systemic* ; Parturition ; Physical Examination ; Pruritus ; Sensation ; Skin ; Spleen ; Vital Signs

The authors experienced a case of generalized bytomegalic inclusion diseas, characterized by numerous petechiae associated with anemia and hepatomegly, in the premature infant who was hypotonic and cyanosed, with respiratory difficulty and an Apgar score of 4 at 1 minute. The rapid deterioration of the case condition was followed by the death occurring nine hours after birth. The diagnosis was confirmed by the autopsy, and a brief review of the literature was made.
Anemia ; Apgar Score ; Autopsy* ; Cytomegalovirus Infections* ; Diagnosis ; Humans ; Infant, Newborn ; Infant, Premature ; Parturition ; Purpura

No abstract available.
Diabetic Ketoacidosis* ; Lung Abscess* ; Lung* ; Mucormycosis*

A case of histiocytic medullary reticulosis in 14-years-old girl was presented, who had characteristic clinical and histiopathologic findings. The patient manifested intermitten fever, general weakness, weight loss, multiple skin lesion and pancytopenia with terminal massive bleeding. The clinical finding with fatal course and hematologic features were basically identical to those of previously documented histiocytic medullary reticulosis and verified with autopsy. On autopsy, systemic proliferation of the actively phagocytic atypical histiocytes was found. The authors report the case with review of pertinent literature.
Autopsy ; Female ; Fever ; Hemorrhage ; Histiocytes ; Humans ; Pancytopenia ; Skin ; Weight Loss

This study was conducted to evaluate three different mixed formulations of sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) using a low-humidity air flow-induced rat dry eye model and determine the most suitable mixture. The total thickness of the cornea, corneal epithelial thickness, corneal stroma thickness, damaged corneal epithelium percentage region, thickness of the bulbar conjunctiva epithelium, number of goblet cells, goblet cell occupation percentage region, and damaged bulbar conjunctiva epithelium percentage region were measured by histomorphological evaluation. After 5 h exposure to drying airflow, the thickness of the cornea and conjunctiva was decreased with desquamation of the corneal and conjunctiva epithelium. However, these dry eye symptoms were markedly inhibited by treatment with the reference and test formulations. More favorable effects on decreased thickness were detected in response to the CMC than the SH. However, SH had a greater protective effect against corneal and conjunctiva epithelial damage. The application of a mixture of 0.1% SH and 0.2% CMC showed more favorable effects on the corneal and conjunctival damage and the stabilization of the ocular surface than SH or CMC alone.
Animals ; Carboxymethylcellulose Sodium* ; Conjunctiva ; Cornea ; Corneal Stroma ; Epithelium ; Epithelium, Corneal ; Goblet Cells ; Hyaluronic Acid* ; Occupations ; Rats* ; Sodium*