No abstract available.
Child* ; Humans

No abstract available.

No abstract available.
Extracorporeal Circulation* ; Heart* ; Potassium* ; Thoracic Surgery*

No abstract available.

The objective of the present study was to examine the effects of beta-glucan originating from Aureobasidium on full-thickness skin wound healing in diabetic C57BL/KsJ-db/ db mouse models. In the diabetic C57BL/KsJ-db/db model, test articles were topically applied twice a day for 20 days starting from 1 day after wounding. The results were compared to that of MadecassolTM ointment (madecassol; 1% Centella asiatica extracts) topically applied at a concentration of 100 mg/kg. Treatment with beta-glucan resulted in significant (p<0.01 or p<0.05) and dose-dependent decreases in wound size compared with that of vehicle control showing increased wound size (WS, %). In addition, 50% contraction time (CT50) was dramatically and dose-dependently reduced, and inflammatory cells in granulation tissues of the wound area were significantly (p<0.01 or p<0.05) and dosedependently reduced compared with that of vehicle control showing increased numbers of micro-vessels and fibroblasts as well as re-epithelialization. In the madecassol group, similar changes in inflammatory cells and fibroblasts with re-epithelialization were also observed, but madecassol did not influence angiogenesis. No meaningful changes in body weight were detected in all tested groups compared with the vehicle control. Therefore, these data suggest that beta-glucan has a beneficial effect on diabetic delayed skin wound healing and may be useful to manage incurable skin wounds in diabetic animals.
Animals ; Body Weight ; Centella ; Fibroblasts ; Granulation Tissue ; Mice* ; Re-Epithelialization ; Skin ; Wound Healing* ; Wounds and Injuries*

Clinicopathological features were evaluated retrospectively for 17 ureters in 13 patients with primary obstructed megaureter. The mean age of patients was 8 years. Nine patients had unilateral and 4 had bilateral entity Clinical presentations included febrile UTI and flank pain in 5 patients respectively, and prenatally detected hydroureteronephrosis, abdominal mass and hematuria in each patient. Associated abnormalities of upper urinary system were found in 4 patients: UPJ obstruction with hypoplastic kidney, contralateral renal agenesis, contralateral hypoplastic kidney, and contralateral multicystic dysplastic kidney. Excision of obstructed segment and reimplantation with or without tapering was performed in 16 ureters. Also, correction of UPJ obstruction and nephrectomy for MCDK were needed. Thirteen ureters in 10 patients showed structural urographic improvement, but 3 ureters in 2 patients were not changed at mean follow up of 25 months. Reflux was seen postoperatively in 1 patient, which resulted in repeated reimplantation. Histopathologic examination of resected distal narrowed ureters showed ureteral muscular dysplasia, dense collagen infiltration and circular muscular hypertrophy in all specimens. These changes were seen not only in distal ureteral segment but also in upper dilated segment, and seemed to be more severe in patients who had associated upper tract problems. Primary obstructed megaureter showed various clinicopathological features and was frequently associated with ipsilateral or contralateral upper tract anomalies. Early meticulous imaging and surgical correction will lead to excellent result.
Collagen ; Flank Pain ; Follow-Up Studies ; Hematuria ; Humans ; Hypertrophy ; Kidney ; Multicystic Dysplastic Kidney ; Nephrectomy ; Replantation ; Retrospective Studies ; Ureter*

No abstract available.
Fistula*

Histomorphologic study was performed on bilaterally testicular biopsies of 30 preadolescent patient with unilateral cryptorchidism so as to understand pathophysiology of the increased incidence or infertility, seen in unilateral cryptorchidism. The results demonstrated delayed and defective transformation of gonocytes to spermatogonia, delayed or failed transformation of spermatogonia to primary spermatocyte and decreased numbers of Leydig cells. These abnormalities were present in the unilaterally cryptorchid testis and their contralateral descended partners but they were more serious and earlier onset in the cryptorchid testis. That is to say, blunted surge in gonadotropins triggers atrophy of Leydig cells leading to delayed and defective maturation of germ cells leading to decreased numbers of germ cells. These findings are compatible with the hypothesis that hypo gonadotropic hypogonadism is the cause of cryptorchidism.
Atrophy ; Biopsy ; Cryptorchidism* ; Germ Cells ; Gonadotropins ; Humans ; Hypogonadism ; Incidence ; Infertility ; Leydig Cells ; Male ; Spermatocytes ; Spermatogonia ; Testis*

No abstract available.

No abstract available.
Blood Platelets* ; Cardiopulmonary Bypass*