1.Rhabdomyolysis in a Cyclosporine-treated Renal Transplant Recipient Who Received Atorvastatin as Replacement for Fluvastatin.
Wan Bok LEE ; Jin Woo PARK ; Min Soo SONG ; Moo Yong PARK ; Young Kwan CHO ; Bo Yong JEUNG ; Hyo Wook GIL ; Jong Oh YANG ; Eun Young LEE ; Sae Yong HONG
Korean Journal of Nephrology 2004;23(5):836-839
Statin-induced rhabdomyolysis is a frequent complication in renal transplant recipients receiving cyclosporine, but incidences are different between different types of statins. Statins have different pharmacokinetic properties. Atorvsatatin, simvastatin, lovastatin, and cerivastatin are all metabolized by the cytochrome P450 isoenzyme 3A4 and co-administration of cyclosporine which may inhibit cytochrome P450 isoenzyme 3A4, increases statin levels and therefore increases the risk of rhabdomyolysis. Fluvastatin is metabolized by cytochrome P450 isoenzyme 2C9 and no clinically significant interactions with cyclosporine have been reported. Atorvastatin with co-administration of cyclosporine in renal transplant patients may induce drug interactions, therefore we recommend the routine monitoring of muscle enzymes, in these cases. Here, we reported a case of rhabdomyolysis in a patient who received atorvastatin and cyclosporine with the review of the literature.
Cyclosporine
;
Cytochrome P-450 Enzyme System
;
Drug Interactions
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors
;
Incidence
;
Lovastatin
;
Rhabdomyolysis*
;
Simvastatin
;
Transplantation*
;
Atorvastatin Calcium
2.A Case of Primary Hyperparathyroidism Caused by Cystic Parathyroid Adenoma, Diagnosed during Intra-Operative PTH Monitoring.
Hye Jin YOO ; Nan Hee KIM ; Soo Yeon PARK ; Dong Jin KIM ; Sae Jeung YANG ; Ju Ri PARK ; Hee Young KIM ; Ji A SEO ; Kye Won LEE ; Sin Gon KIM ; Kyung Mook CHOI ; Jae Bok LEE ; Young Seok LEE ; Sei Hyun BAIK ; Dong Seop CHOI
Journal of Korean Society of Endocrinology 2005;20(3):278-282
Primary hyperparathyroidism is the most frequent cause of hypercalcemia, and its prevalence is increasing due to the routine examination of serum calcium levels. Primary hyperparathyroidims is most commonly caused by an adenoma or hyperplasia of the parathyroid gland. A cystic parathyroid adenoma is an extremely rare cause of primary hyperparathyroidism. In our case, a-79-year old female presented with lower back pain and constipation. Her serum calcium, phosphate and immunoreactive parathyroid homone levels were 15.6, 1.8mg/dL and 371.8pg/mL, respectively. Neck CT revealed a cystic mass and a contour bulging heterogeneous mass in the left inferior right thyroid gland, respectively. These mass lesions were removed, and the intra-operative parathyroid hormone levels monitored, to confirm the complete resection. After removing the left cystic mass to the inferior thyroid, the serum calcium and immunoreactive parathyroid hormone levels quickly returned to normal. We report a case of primary hyperparathyroidism, caused by a cystic parathyroid adenoma, with a brief review of the literature
Adenoma
;
Calcium
;
Constipation
;
Female
;
Humans
;
Hypercalcemia
;
Hyperparathyroidism
;
Hyperparathyroidism, Primary*
;
Hyperplasia
;
Low Back Pain
;
Neck
;
Parathyroid Glands
;
Parathyroid Hormone
;
Parathyroid Neoplasms*
;
Prevalence
;
Thyroid Gland
3.A Case of Primary Hyperparathyroidism Caused by Cystic Parathyroid Adenoma, Diagnosed during Intra-Operative PTH Monitoring.
Hye Jin YOO ; Nan Hee KIM ; Soo Yeon PARK ; Dong Jin KIM ; Sae Jeung YANG ; Ju Ri PARK ; Hee Young KIM ; Ji A SEO ; Kye Won LEE ; Sin Gon KIM ; Kyung Mook CHOI ; Jae Bok LEE ; Young Seok LEE ; Sei Hyun BAIK ; Dong Seop CHOI
Journal of Korean Society of Endocrinology 2005;20(3):278-282
Primary hyperparathyroidism is the most frequent cause of hypercalcemia, and its prevalence is increasing due to the routine examination of serum calcium levels. Primary hyperparathyroidims is most commonly caused by an adenoma or hyperplasia of the parathyroid gland. A cystic parathyroid adenoma is an extremely rare cause of primary hyperparathyroidism. In our case, a-79-year old female presented with lower back pain and constipation. Her serum calcium, phosphate and immunoreactive parathyroid homone levels were 15.6, 1.8mg/dL and 371.8pg/mL, respectively. Neck CT revealed a cystic mass and a contour bulging heterogeneous mass in the left inferior right thyroid gland, respectively. These mass lesions were removed, and the intra-operative parathyroid hormone levels monitored, to confirm the complete resection. After removing the left cystic mass to the inferior thyroid, the serum calcium and immunoreactive parathyroid hormone levels quickly returned to normal. We report a case of primary hyperparathyroidism, caused by a cystic parathyroid adenoma, with a brief review of the literature
Adenoma
;
Calcium
;
Constipation
;
Female
;
Humans
;
Hypercalcemia
;
Hyperparathyroidism
;
Hyperparathyroidism, Primary*
;
Hyperplasia
;
Low Back Pain
;
Neck
;
Parathyroid Glands
;
Parathyroid Hormone
;
Parathyroid Neoplasms*
;
Prevalence
;
Thyroid Gland