Familial hemophagocytic lymphohistiocytosis (FHL) is a rapidly fatal illness, usually encountered in infancy, characterized by fever, hepatosplenomegaly, pancytopenia, and central nervous system involvement. Microscopic examination of tissue shows a non-malignant lymphohistiocytic infiltrate, with prominent erythrophagocytosis. FHL is an autosomal recessive hereditary disorder but may develop secondarily to other conditions such as immunosuppression, malignancies, fat overload and certain infections. We recently experienced a case of siblings developing FHL, which may be associated with EBV infection.
Case Report ; Child, Preschool ; Female ; Herpesviridae Infections/complications* ; Herpesvirus 4, Human* ; Histiocytosis, Non-Langerhans-Cell/virology* ; Histiocytosis, Non-Langerhans-Cell/genetics* ; Human ; Infant ; Male ; Tumor Virus Infections/complications*

The authors calculated the number of blood cultures per 1,000 admitted patient days at seven university-affiliated hospitals in 2010, which ranged from 65 to 129 (mean 110). The number of blood cultures per 1,000 patient days could possibly be a good parameter for assessing the appropriateness of blood culture.
Humans ; Korea ; Quality Control ; Sepsis