Objective To explore the best time for the first wrist bandage decompression in patients with coronary artery intervention after radial artery puncture operation. Methods A total of 165 patients were randomly divided into observation group ( n=85 ) and control group ( n=80 ) . Wrist bandage decompression time was 60 min and 90 min after operation in the observation group and in the control group. We recorded blood oxygen saturation (SpO2) of operated hand and unaffected hand at 15, 30, 45, 60, 90 and 120 min of post-operation. Then, we compared the differences of vascular complication and degrees of comfort. Results The SpO2 was (94. 48 ± 2. 585)% and (95. 06 ± 2. 014)% in operated hand and unaffected hand at 15 min after operation in the observation group (t= -0. 118, P<0. 05). The SpO2 was (94. 41 ± 1. 992)% and (95. 25 ± 2. 149)% in operated hand and unaffected hand at 120 min in the control group (t= -3. 617, P<0. 01). The SpO2 was no significant difference between these six time points in operated hand (t= -0. 233, 0. 269, 0. 992,-0. 203, 0. 297, 0. 670; P>0. 05). There was no incision bleeding and radial artery occlusion in both two groups. There was 1 case upper arm swelling and 1 case ecchymoma in the observation group. There was no statistically difference between vascular complication and degree of comfort (χ2 =4. 023, 1. 418, P>0. 05). Conclusions Best time for the first wrist bandage decompression was 60 min after coronary artery intervention, which can decrease the risks of vascular complication and increase degree of comfort.