Amphotericin B is a fungicide which has proven to be very effective in the treatment of a number of systemic mycotic infections. The problem with treatment by the drug has been its toxicity. Infact, the studies of these side effects have become and important part of the research project. This report is an exparimental study about histopathological changes in internal organs after amphotericin B administration in rats. Amphotericin B was given 5mg/kg or 15mg/kg intraperitoneally and the rats were killed 6 hr, 24 hr and 48 hr after the administration.
Amphotericin B ; Animals ; Dermatology* ; Fluorescent Antibody Technique* ; Rats