1.Impact of hydroxyethyl starch 70/0.5 on acute kidney injury after gastroenterological surgery.
Takeshi UMEGAKI ; Takeo UBA ; Chisato SUMI ; Sachiyo SAKAMOTO ; Sachiko JOMURA ; Kiichi HIROTA ; Koh SHINGU
Korean Journal of Anesthesiology 2016;69(5):460-467
BACKGROUND: Previous studies reported a higher mortality risk and a greater need for renal replacement therapy in patients administered hydroxyethyl starch (HES) rather than other fluid resuscitation preparations. In this study, we investigated the association between 6% HES 70/0.5 use and postoperative acute kidney injury (AKI) in gastroenterological surgery patients. METHODS: We conducted retrospective full-cohort and propensity-score-based analyses of patients who underwent gastroenterological surgery between June 2011 and August 2013 in a Japanese university hospital. The study sample comprised 66 AKI and 2,152 non-AKI patients in the full-cohort analysis and 35 AKI and 1,269 non-AKI patients in the propensity-score-based analysis. Propensity scores were calculated using an ordered logistic regression model in which the dependent variable comprised three groups based on HES infusion volumes (0, 1–999, and ≥ 1,000 ml). The association between HES groups and postoperative AKI incidence was analyzed using multiple logistic regression models. Other candidate independent variables included patient characteristics and intraoperative measures. RESULTS: In the full-cohort analysis, 40 (60.6%) AKI patients were diagnosed as "risk", 15 (22.7%) as "injury," and 11 (16.7%) as "failure". In the propensity-score-based analysis, the corresponding values were 22 (62.9%), 8 (22.9%), and 5 (14.3%). There was no significant association between total infused HES and postoperative AKI incidence in either the full-cohort or the propensity-score-based analysis (P = 0.168 and P = 0.42, respectively). CONCLUSIONS: AKI incidence was not associated with clinical 6% HES 70/0.5 administration in gastroenterological surgery patients treated at a single center.
Acute Kidney Injury*
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Asian Continental Ancestry Group
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Humans
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Incidence
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Logistic Models
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Mortality
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Propensity Score
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Renal Replacement Therapy
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Resuscitation
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Retrospective Studies
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Starch*
2.Eruptive Xanthoma with Acute Pancreatitis in a Patient with Hypertriglyceridemia and Diabetes.
Tomoko INOUE-NISHIMOTO ; Takaaki HANAFUSA ; Ayaki HIROHATA ; Eriko KIYOHARA-MABUCHI ; Naho MIZOGUCHI ; Kohei MATSUMOTO ; Sachiko SAKAMOTO ; Masako ZENIBAYASHI ; Satoshi MIYATA ; Ryuta IKEGAMI
Annals of Dermatology 2016;28(1):136-137
No abstract available.
Humans
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Hypertriglyceridemia*
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Pancreatitis*
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Xanthomatosis*