1.Effects of ascorbate on the differentiation of B lymphocytes in sarcoma 180-implanted mice.
Young Jun KANG ; Jeong Hye ROH ; Sa Ouk KANG ; Ga Jin JEONG
Korean Journal of Immunology 1993;15(2):227-233
No abstract available.
Animals
;
B-Lymphocytes*
;
Mice*
;
Sarcoma*
2.A Clinicoelectroencephalographic Study of Febrile Convulsion in Childhood.
Kwang SHIM ; Ook Jung KANG ; Sa Jun CHUNG ; Chang Il AHN
Journal of the Korean Pediatric Society 1984;27(7):725-732
No abstract available.
Seizures, Febrile*
3.Oculodentodigital dysplasia : 1 case.
Dong Il SUN ; Sa Yong CHAE ; Jun Myong KANG ; Byung Do SUH
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(5):1071-1074
No abstract available.
4.Age and Dosage-related Longitudinal Changes in Body Mass Index on Epileptic Children Treated with Topiramate.
Young Lan KWEON ; Kang Hoon SONG ; Sa Jun CHUNG
Journal of the Korean Child Neurology Society 2010;18(1):14-19
PURPOSE: The objective of this prospective study is to assess changes in body mass index(BMI, weight in kilograms/height in meters2) according to age and dosage on epileptic children treated with topiramate. METHODS: From January 2006 to December 2008, prospective studies have been performed on 63 children with epilepsy aged below 15 old who had been treated with topiramate. Patients were classified into 3 groups according to age: 2-5 years as a group 1; 6-10 years as a group 2; 11-15 years as a group 3;, and classified into 2 groups according to dosage: from 2 to 5 mg/kg/day as group A, more than 5 mg/kg/day to 8 mg/kg/day as group B. We have checked BMI of patients four times and evaluated the changes in BMI of each group. RESULTS: BMI at initial presentation and follow-up periods of 6, 12, and 24 months is as follows: 16.3+/-1.25, 14.3+/-1.8, 14.2+/-2.4, and 15.7+/-2.1 in the group 1, 18.5+/-1.23, 15.2+/-1.24, 14.8+/-2.27, and 16.8+/-2.5 in the group 2, 21.6+/-2.31, 16.5+/-2.17, 15.4+/-2.56, and 15.1+/-1.3 in the group 3. Comparing with group A and B is as follows: 19.3+/-2.35 and 18.1+/-1.89 at initial presentation, 15.5+/-2.45 and 15.1+/-1.15 at 6 months, 14.9+/-2.15 and 14.7+/-1.91 at 12 months, 15.9+/-1.28 and 16.0+/-1.12 at 24 months. CONCLUSION: The effect of topiramate on changes of BMI shows difference according to age. In groups of 2-10 years old, BMI was rebounded from lowest value after 12 months, however, in the group of 11-15 years old, BMI kept decreasing at 24 months. And dosage of topiramate does not affect to BMI significantly.
Aged
;
Body Mass Index
;
Child
;
Epilepsy
;
Follow-Up Studies
;
Fructose
;
Humans
;
Prospective Studies
5.Clinical Analysis of Traumatic Hemorrhage in Child's Basal Ganglia: Eight Cases.
Sa Jun KANG ; Jae Hyoo KIM ; Jung Hyun WOO
Journal of Korean Neurosurgical Society 1987;16(3):727-736
Recently, the detection of traumatic intracerebral hematoma has been greatly expedited by the advent of computed tomography. However, traumatic basal ganglia hemorrhage(TBGH) in child have remained rare. The authors obtained following results with analysis of clinical features and outcome in 8 cases of child's TBGH who had been treated at the department of neurosurgery, chonnam university hospital from January 1984 to December 1986. 1) Age distribution was ranged from 3 to 9 years with an average age 5.1 years and 5 were males and 3 were females. 2) Blow of site of the head were right frontal 3, left frontal 3, right parietal 1 and right temporal 1. However, hematoma in the basal ganglia occurred 6 in the left and 2 in the right. 3) On admission, the consciousness level appeared 2 cases in drowsy state(GCS 13), 3 cases in stuporous state(GCS 8,9) and 3 cases in semicomcatose state(GCS 5,7). 4) CT findings of TBGH were classified into 3 types; Type I; spotty type, Type II; moderate type and Type III : massive type. The number of patients was 4 in type I, 2 in type II and 2 in type III. 5) Neurological examination revealed contralateral hemiparesis to the hematoma in all cases(8), facial nerve palsy in 3 cases, motor aphasia in 4 cases and decerebrate rigidity in 2 cases. 6) Of all cases (8), conservative treatment were done in 5 and surgical treatment in 3. As regards the outcome of all cases (8), showed good recovery in 3, moderate disabilety in 2 and death in 3. It was concluded that the first regimen to be chosen in the management of TBGH in child was medical treatment. The patient of moderately disturbed conseionsness would be successfully managed by conservative treatment. The indication for surgery should be restricted to such cases in which the consciouness status were getting worse in spite of active conservative treatment.
Age Distribution
;
Aphasia, Broca
;
Basal Ganglia*
;
Child
;
Consciousness
;
Decerebrate State
;
Facial Nerve
;
Female
;
Head
;
Hematoma
;
Hemorrhage*
;
Humans
;
Jeollanam-do
;
Male
;
Neurologic Examination
;
Neurosurgery
;
Paralysis
;
Paresis
;
Rabeprazole
;
Stupor
6.Asymptomatic HyperCKemia Presenting as a Sole Manifestation of Hypothyroidism.
Sun Woo PARK ; Hong Jun KIM ; Sa Yoon KANG
Korean Journal of Clinical Neurophysiology 2014;16(1):45-47
No abstract available.
Creatine Kinase
;
Hypothyroidism*
;
Muscular Diseases
7.Evaluation criteria for rat skin anaphylactoid test.
Li-jing KANG ; Jia-jun XIE ; Lin ZHAO ; Juan-juan YI ; Yu-sa HUANG ; Ke-feng RUAN
China Journal of Chinese Materia Medica 2015;40(20):4044-4051
This study is to explore characteristic indexes in evaluation criteria for rat skin anaphylactoid test comparing skin blue spot OD values at the treated position and the control position in the same animal. Common contrast agents, traditional Chinese medicine injections and injections' active pharmaceutical ingredients or excipients in the existing clinical anaphylactoid reaction reports were taken as test drugs in the rat skin anaphylactoid test to define the K value: K > 2 represents positive anaphylactoid reaction, 1.2 ≤ K ≤ 2 represent doubtable anaphylactoid; K < 1.2 represents negative anaphylactoid reaction, which were taken as the criteria for evaluating anaphylactoid of tested drugs. The evaluation result and that for classic criteria were compared to study the applicability of K value. According to the comparison, K value, as the evaluation criteria in the rat skin anaphylactoid test, can more truly reflect the actual situation of skin aizen and minimize the error caused by animal individual factors. Compared with positive and negative two-level criteria for blue spot diameter, K value's positive, doubtable and negative three-level criteria are more objective and accurate. Therefore, K value can be used as the evaluation criteria in the rat skin anaphylactoid test.
Animals
;
Drug Hypersensitivity
;
immunology
;
Drugs, Chinese Herbal
;
adverse effects
;
Female
;
Humans
;
Rats
;
Rats, Sprague-Dawley
;
Skin Tests
;
methods
8.Acute superior mesenteric artery occlusion-report of 5 cases-
Sung Soo KIM ; Won Hyun CHO ; Yoo Sa KIM ; Ki Yong JUNG ; Joong Shin KANG ; Suk Kil JUN
Journal of the Korean Society for Vascular Surgery 1993;9(1):149-155
No abstract available.
Mesenteric Artery, Superior
9.Myasthenia Gravis Presenting with Facial Diplegia without Ocular Muscle Involvement.
Chul Hoo KANG ; Hong Jun KIM ; Jung Hwan OH ; Sa Yoon KANG
Korean Journal of Clinical Neurophysiology 2015;17(1):35-37
No abstract available.
Facial Paralysis
;
Myasthenia Gravis*
10.Arg460Cys Mutation in SPAST Gene in Patients with Hereditary Spastic Paraplegia.
Hong Jun KIM ; Chul Hoo KANG ; Jung Hwan OH ; Sa Yoon KANG
Journal of the Korean Neurological Association 2015;33(4):321-323
Hereditary spastic paraplegia is a group of genetically and clinically heterogeneous neurodegenerative disorder characterized by progressive lower extremity weakness and spasticity. A 49-year-old man presented with progressive gait disturbance. Neurological examination showed spasticity, hyperreflexia in lower extremity and bilateral ankle clonus. He had a family history consistent with autosomal dominant inheritance. Gene testing revealed a heterozygous missense mutation (c.1378C>T [p.Arg460Cys]) in SPAST gene. We report a first Korean family with Arg460Cys mutation in SPAST gene.
Ankle
;
Gait
;
Humans
;
Lower Extremity
;
Middle Aged
;
Muscle Spasticity
;
Mutation, Missense
;
Neurodegenerative Diseases
;
Neurologic Examination
;
Paraplegia
;
Reflex, Abnormal
;
Spastic Paraplegia, Hereditary*
;
Wills