Spiritual motivation is the basic means of mental reconstruction and behavior improvement.Medical ethics education is a process that fully develop medical resources,mine the essence of western traditional thinking of medical ethics,teach the basic principles of medical ethics,and medical ethics norms,play the role of medical model,train the noble medical ethics emotion,and develop good medical ethical behaviors.Based on the present situation of medical ethics education,this article explores the features of spiritual motivation and its application.

Objective: To study the mechanism of the preventive effects of soybean isoflavones on osteoporosis. Methods: The serum collected from experimental rats given soybean isoflavones extract was added to the culture system of osteoblast cells (OB) isolated from the calvaria of neonatal SD rats. MTT assay was employed to determine cell proliferation. The activity of alkaline phosphatase (ALP) and bone gla protein (BGP) were determined by ALP and BGP Kits. The content of IL 6 secreted by OB was determined by ELISA Kit. Results: Isoflavones could stimulate OB proliferation, elevate the activity of ALP and BGP level. They had no apparent effects on the secretion of IL 6. Conclusion: Soybean isoflavones can promote proliferation and differentation of OB in vitro and have no remarkable influence on bone absorption. The effects of soybean isoflavones on osteoporosis seem to depend on stimulation of bone formation rather than suppression of bone absorption.

By studying the developmental strategy of the revonal medical science and technology and implementation condition from 2001 to 2004 as well as systematically studying the national policy of the scientific and technical field,we proposed the developmental strategy of medical science and technology in Shanghai that the priority for the introduction,the application and the popularization of new or suitable technology should be given,also continuous advancement in technology should be kept.As a result,it is possible to provide the people a safer,more effective,convenient and moderately priced public health and basic medical service.During the past 5 years.we made an experimental work in selected Pudong in Shanghai.It Was proved that the strategy tallies with the actual situation of Pudong and is effectual in practice.

Humans ; Immunoglobulin Light Chains ; genetics ; immunology ; Immunoglobulin kappa-Chains ; genetics ; immunology ; Kidney ; immunology ; metabolism ; pathology ; Kidney Diseases ; immunology ; pathology ; therapy ; Mutation ; Transforming Growth Factor beta ; metabolism

High intensity focused ultrasound (HIFU) is a novel physical tumor therapeutic technology which applies the ultrasound well targeting, focusing, tissue absorbing property, and so on. It focused outer transducer low intensity ultrasound wave and targeted in the tumor, whichcan raise the temperature above 60℃ rapidly and induce tissue irreversible coagulation necrosis, with no damage to the surrounding normal tissue. It is a new physical tumor treatment technology.

Objective To explore the early(Ⅰ,Ⅱ)in modified radical mastectomy of breast cancer clinical value of preserving intercostobrachial nerve.Methods A retrospective analysis of 62 cases of early breast cancer patients with the clinical data,on intraoperative complete preservation of the intercostobrachial nerve in 46 cases as the observation group,intraoperative resected intercostobrachial nerve in 16 cases as control group,comparative analysis of the two groups after the upper medial arm and axilla skin paresthesia and breast cancer recurrence.Results All 62cases underwent modified radical mastectomy of breast cancer,all patients were cured.The observation group upper medial arm and axillary skin sensory abnormalities in 5 cases(10.9％),significantly lower than the control group of 16 cases(100％)(x2 =19.27,P ＜0.05).A mean follow-up of 1 year,the observation group in upper arm skin party abnormalities in patients with 5 cases,after 1 ～ 3 mongths recovery ;control group of sensory abnormalities were not returned to normal; the two groups were not found in local tumor recurrence or distant metastasis.Conclusion In modified radical mastectomy of breast cancer reserving intercostobrachial nerve was feasible,and could significantly reduce the postoperative lateral medial arm and axilla skin feeling abnormal rate,and improve the quality of life in patients.

Objective To observe effect mechanism of L-arginine (L-arg,a precurory substance of nitric oxide sythesis) in proveting proteinuria in adriamycin-induced nephrosis model of rats.Methods Nephrosis model of 16 rats was established by tail vein injetion with adriamycin,then the 16 rats were divided into two groups;model group and treatment group with L-arg administration (treated group),the levels of nitric oxide(NO),endothelin-1(ET-1),renal function,and pathological changes were observed in the two groups.Results The successful nephrosis model of rats was indentified with optical and electron microscope technique.Proteinuria was occurred in the two groups,but proteinuria degree in treated group was lighter than those of model group,however NO level was higher than that of model group,there was negatively correlation in the levels of NO and ET-1 between both groups,pathological alteration under electron microscope observation was obviously less in the treatment group than those of the model group.Conclusions On basis of these findings,author consider that the L-arg could reduce proteinuria output by promoting NO synthesis and suppress the ET-1 production.

Electron microscopic changes about the effect of gossypol acetic acid ongastrocnemius muscles of male monkeys,rats and guinea pigs were studied.The resultsare as follows:The ultrastructure of gastrocnemius muscles of adult male Rhesus monkeys afteradministration of gossypol orally with a daily dose of 4mg/kg for 2 years showedapparently normal in appearance,except some nuclear condensation and dissociationof nuclear membrance seen in individual animal.After oral aministration of gossypol in adult male Wistar rats with an antifertilitydosage,i.e 20mg or 30mg/kg/day for 30 days,no obvious difference was seen betweenthe experimented and control groups.Except mild distension of the smooth endoplasmicreticulum and dissociation of nuclear membrane sometimes seen in some of theexperiment animals.Similar results was obtained in the male guinea pigs.After a heavy dose(60mg/kg/day)of gossypol given to rats for 37 days,mostof the myofibrils still keep their normal periodic structures,each fiber is maintainingtheir transversly arranged pattern of dark A-bands and light I-bands alternativelyalong the whole length of the fiber.But some myofibrils had lost their normal striation.The width of the I-band increased and the breaking down or lysis precessesin few or even an individual myofibril had begun.There were no obvious pathologicalchanges seen in the mitochondria.Persistent oral administration of gossypol in ratewith a dosage of(60mg/kg/day)for 55 days,the pathological changes became moreobvious.The mitochondria became disordered in arrangement.Concomitant with thesschanges,the myofibrils appeared dystropic and fragmented.It indicated the presenceof myofibrillar degeneration.If the daily dose are increased to 60mg/kg for 25 days in guinea pigs.Theremight be no significant pathological changes in the myofibrils in them.Nevertheless,some mitochondria were swollen in various extents and the cristae became fragmentedor dissolved,which was known as mitochondrial necrosis.The relationship between hypokalemic paralysis and the present results inducedby toxic effect of gossypol were analysed and discussed.

Objective To understand the characteristics of indoor PM2.5 pollution in residential houses in Guangzhou. Methods Indoor PM2.5 samples were collected in nine residential sites using mini-volume sampler in Guangzhou in summer (June to July, 2003). Mass concentration of PM2.5 and the organic carbon (OC) and elemental carbon (EC) levels in PM2.5 were measured. Results The average concentration of PM2.5 was (47.4?17.7) mg /m3, a relatively high concentration compared to the previous studies in other cities. The OC and EC concentrations in PM2.5 were (12.5?8.7) and (4.4?2.3) mg /m3 respectively. OC and EC counted for 24.6%?5.6% and 9.9%?4.8% in indoor PM2.5. However, it was estimated that OC mainly came from indoor sources and EC related well with outdoor sources, which conformed to the source investigation. Conclusion Cooking, smoking and outdoor sources are the prominent contributors to the indoor PM2.5 pollution. Housing conditions such as decoration and ventilation may affect the indoor PM2.5 level.

Objective To investigate the effect of compound azintamide enteric-coated tablet on abdominal fullness in patients with functional dyspepsia, chronic cholecystitis with gallbladder stones, or liver cirrhosis. Methods Twenty patients with functional dyspepsia, 20 with chronic cholecystitis and gallbladder stones, and 20 with liver cirrhosis were enrolled in the study. Compound azintamide enteric-coated tablets were given 2 tablets 3 times daily for 4 weeks. The changes of symptom scores of abdominal fullness were investigated after the treatment. Water loading tests were carried out in patients with functional dyspepsia and chronic cholecystitis with gallbladder stones before and after the medication. Results Compound azintamide enteric-coated tablets greatly improved the symptom of abdominal fullness in each group of patients. Symptom scores were significantly decreased in 2 and 4 weeks (P