Atopic dermatitis is a common chronic recurrent atopic constitution-associated inflammatory skin disease mainly characterized by eczematous lesions and itching. Its etiology and pathogenesis are still not very clear, and there are many controversies about its origin, definition, clinical phenotypes and diagnostic criteria. This review analyzes and discusses these controversies in order to provide a meaningful reference for the diagnosis and treatment of atopic dermatitis.

Chinese genuine regional herbs are a combination of nature resource and traditional knowledge. Although we can make it to be an intellectual property product through applying geographical indication or certification mark, the value realization of Chinese genuine regional herbs should be supported by the merchant capital. Meanwhile, the merchant capital also disturbs the reasonable market price of Chinese genuine regional herbs. We should combine the merchant capital with Chinese genuine regional herbs, apply permission for sale and set up a new professional cooperation mode to maintain the market credibility and reasonable price of Chinese genuine regional herbs.

Postprandial hyperglycemia is one of the characteristics of glucose profiles in Chinese T2DM patients. High-ratio premix insulin analogues with advantages of excellent pharmacokinetic characteristics and flexible and convenient administration provide a comprehensive solution for Chinese T2DM patients to effectively control postprandial glucose and reduce blood glucose fluctuation. This paper is a literature review on its clinical evidence and experience.

No abstract available.
Animals ; Embryo Implantation* ; Embryonic Structures* ; Female ; Mice* ; Pregnancy

No absteact available.
Resuscitation*

Objective To investigate the effect and drug resistance patterns of Adefovir dipivoxil in the treatment of chronic hepatitis B (CHB) .Methods CHB patients were divided in to HBeAg positive (n=108) and HBeAg negative (n=55) groups.The liver function tests, HBVDNA and HBVM were analyzed during the treatment.The virus resistance mutation gene and nucleic acid amplification were performed by fluorescence quantitative sequencing in ineffective patients or patients with HBVDNA rebound ≥1 log10copies/ml.Results HBVDNA negativity reached its peak at the 48th week of treatment in HBeAg positive and HBeAb negative groups with a rate of 70.7% and 77.7% , respectively.HBeAg negativity and anti-HBe seroconversion rates were 37.5% and 25.0% , respectively in HBeAg-positive group and the rate was increased year by year.The HBVDNA negativity decreased at 144th week in both groups and the decrease in HBVDNA negativity in HBeAg negative group (40.0% ) was more than the HBeAg-positive group (9.4% ) (P < 0.01) .24 weeks after cessation of treatment, 12 and 4 patients with or without standard treatment, respectively were showed recurrence.From the total of 19 patients with liver cirrhosis, seven patients (36.8% ) developed liver cancer and chronic liver failure within 48 weeks of treatment.71.4% of HBeAg-negative cirrhosis patients with HBVDNA≥105copies/ml before treatment had poor prognosis.During the treatment, 7 cases were shown rebound in which HBVDNA rebound was≥102copies/ml in two of the cases and 96W mutations were found in one patient.Two cases of rtA181IV and rtN236T mutations were found of which one had a short-term drug history.Another two cases of rtL180M and rtM204I/rtT184A mutations were found with a previous history of treatment with LAM, LdT and ETV.Conclusion Dipivoxil for the treatment of the Arab-Israeli group HBVDNA negative response rate up to the summit in the 48th week, HBeAg negative and positive 3 years showed an upward trend year after year.The end of the standard drug treatment and not following the end standard drug treatment time for a similar rebound in viral genes.Anti-Hbe positive cases of liver cirrhosis HBVDNA≥105copies/ml deterioration 1 year after treatment the proportion of large.HBVDNA increased to ≥1log10copies/ml as clinical indicators in line with the virus rebound is not high.

Objective To investigate the influence of swallowing exercise on dysphagia of patients with genuine and false bulbar palsy. Methods Sixty cases with genuine and false bulbar palsy were divided into two groups: rehabilitation exercise group(test group, n =30) and drug group(control group, n =30). Those in the control group were given routine medications and nursing, while those in the test group were given swallowing exercise in addition to the routine treatment. Change of swallowing ability is observed and compared. Results The swallowing ability in the rehabilitation exercise group was better improved than that in the control group. There was significant difference between them ( P

AIM:To investigate the effect of intravitreal ranibizumab ( IVR) in the treatment of exudative age-related macular degeneration ( AMD ) with serous retinal pigment epithelium detachment ( SPED) in elderly patients. ·METHODS: We Selected 60 elderly patients ( 60 eyes ) with AMD and SPED in our hospital from February 2015 to February 2016, treated by intravitreal injection of ranibizumab. The best corrected visual acuity ( BCVA ) , PED height and volume, central fovea thickness ( CFT ) and aqueous humor vascular endothelial growth factor ( VEGF) were measured before and after treatment. ·RESULTS:The BCVA of patients with after treatment for 1, 3 and 6mo were 0. 6 ± 0. 1, 0. 4 ± 0. 1 and 0. 3 ± 0. 1, and were significantly higher than those before treatment ( P<0. 05). At 1, 3 and 6mo after treatment PED height and volume were significantly lower than before treatment (P<0. 05), of which 6mo after the treatment PED height and volume were 240. 02 ± 35. 10μm and 0. 310 ± 0. 120mm3 . At 6mo after treatment CFT was 290. 02±33. 10μm, significantly lower than before and 1mo after treatment (P<0. 05). At 1, 3 and 6mo after treatment VEGF were lower than those before treatment (P<0. 05), in which 6mo after the treatment aqueous humor VEGF was 149. 11 ± 28. 89pg/mL. No endophthalmitis, uveitis and so on adverse reactions were observed during treatment. ·CONCLUSION:IVR has a good effect in the treatment of exudative AMD in elderly patients with serous PED, which can effectively improve the visual acuity of patients, reduce the height and volume of PED and the concentration of VEGF in aqueous humor, and it is safe and reliable.

OBJECTIVE: To evaluate the efficacy of the endoscopic maxillary sinus surgery by lateral wall fenestration of the inferior nasal meatus (EMSLWF). METHOD: Based on traditional Messerklinger sinus surgery, we treat the 17 cases with maxillary sinus disorder by lateral wall fenestration of the inferior nasal meatus, removing the polyp, hemangioma, inverting papilloma, invasive sinus aspergillosis etc, trans aperture maxillary and intranasal window. RESULT: The maxillary sinuses of the 17 cases are clean. Mucosa are well recovered and drained of the mid dle and inferior nasal meatus. We did not find the nasal mucosa pathological changes like the fluid-filled blisters or edema etc. The intranasal windows are closed in only 2 cases (4.25%) after about 2 months. The maxillary sinuses of all cases are still clean with no recurrence of primary diseases. CONCLUSION The EMSLWF is well suitable for dealing with the maxillary sinus diseases. Meanwhile, before the function of the nasal mucociliary transportation system recovered in the perioperative period, the gravity drainage affection should be kept by the intranasal win dow in the inferior nasal meatus. The EMSLWF is worthy of more attention in clinic.
Adolescent ; Adult ; Aged ; Endoscopy ; Female ; Humans ; Male ; Maxillary Sinus ; surgery ; Middle Aged ; Nasal Cavity ; surgery ; Nasolacrimal Duct ; surgery ; Nose ; surgery ; Paranasal Sinus Diseases ; surgery ; Young Adult

“金属材料与热处理技术”是首都医科大学假肢矫形工程专业本科生必修的专业基础课程。金属的晶体结构与滑移系的概念以及铁碳合金相图是“金属材料与热处理技术”教学中比较复杂的知识点。本文对此进行探讨，并提出一些解决方法。