The therapeutic effect of a natural foodstuffs--Wei-Luo powder (WLP)composed of high protein, various essential amino acids, vitamins (B1, B2 and E), and trace elements (Fe, Zn, etc), on both monosodium glutamate (MSG) induced obese mice and alloxan diabetic mice were tested. After 16 days of feeding with WLP diet, the body weight and accumulation of fat in liver and adipose tissue (Lee index) in MSG mice were decreased significantly, WLP diet also caused significant reduction in carbohydrate tolerance of mice as compared with wheat diet. In addition, improvement of hyperglycemia and diabetic symptoms (polydipsia, polyuria and hyperphagia) in alloxan diabetic mice were observed. These results suggest that WLP diet may be beneficial for obesity and diabetic patients.

Objective To compare the clinical effects and safety of olanzapine and aripiprazole in the treatment of schizophrenia .Methods From February 2015 to February 2017 ,100 patients with schizophrenia were chosen in the Third People's Hospital of Yuyao .The patients were randomly divided into A group ( treated with olanzapine ) and B group ( treated with aripiprazole ) , with 50 patients in each group .The clinical efficacy , PANSS score,blood lipid levels and blood glucose level before and after treatment ,and the incidence of adverse effects of the two groups were compared.Results The total effective rates of A group and B group were 86.00％,90.00％, respectively,there was no statistically significant difference between the two groups (χ2 =1.36,P>0.05).There were no statistically significant differences in the PANSS scores after treatment between the two groups ( t=3.17,2.96, 4.21,2.75,3.56,4.01,4.55,4.49,4.71,5.07,4.26,4.92,all P>0.05).After treatment,the levels of FBG,TC and TG of A group were statistically significantly higher than those before treatment (t=3.04,2.68,4.01,P<0.05). The levels of FBG,TC and TG after treatment of B group were significantly lower than those of A group (t=4.81, 3.35,4.14,all P<0.05).The incidence rates of lethargy ,dizziness,insomnia,nausea,vomiting and constipation of A group were 28.00％,38.00％,8.00％,6.00％,36.00％,respectively,which of B group were 2.00％,10.00％, 12.00％,8.00％,10.00％,respectively,and the incidence rates of lethargy ,dizziness and constipation of B group were significantly lower than those of A group (χ2 =9.32,8.77,10.24,all P<0.05),and there was no statistically significant difference in the incidence rates of insomnia ,nausea and vomiting between the two groups (χ2 =2.16, 1.12,all P>0.05).Conclusion Olanzapine and aripiprazole in the treatment of schizophrenia possess the same clinical effects and safety;but aripiprazole can efficiently relieve the influence of blood lipid metabolism and reduce the risk of adverse drug reactions .

Objective: To study the efficacy and safety of oral mucoadhesive containing chitosan for the treatment of recurrent aphothous stomatitis (RAS) Methods: 72 subjects, who were diagnosed with RAS, were involved in the study. The subjects were randomly allocated to the test or control group and shown how to use the films. The film con⁃taining chitosan was provided to the participants in the test group and the polyvinyl alcohol film was provided to the con⁃trol group. Baseline, pain score (visual analog scale), ulcer size and adverse effects were recorded Results : The reduc⁃tion in ulcer size was significantly greater (P < 0.05) in the treatment group (2.91 ± 3.66)mm 2 than in the control group (1.10 ± 2.26) mm 2 between days 4 and 6. There was no significant difference between the treatment and control groups in the pain score, ulcer size, or reduction in the pain score (P > 0.05). No obvious adverse effects were observed. Con⁃clusion The oral mucoadhesive film containing chitosan promotes healing of RAS.

Objective: To investigate the differences and clinical significance of circRNA expression profiles in oral leukoplakia (OLK) tissues and normal oral mucosal (NOM) tissues. Methods: High-throughput sequencing was used to detect differentially expressed circRNAs in 6 pairs of OLK and NOM tissues, and qRT-PCR was used to verify the expression of 10 circRNAs screened in 6 pairs of OLK and NOM tissues. The ring formation of circRNA was verified by RNase R digestion and Sanger sequencing, and the target circHLA-C was further verified by qRT-PCR in 20 pairs of OLK and NOM tissues. CircHLA-C was visualized using the UCSC genome browser (genome.ucsc.edu). The function of differentially expressed circRNAs was analyzed by GO and KEGG enrichment analyses. TargetScan and miRanda predicted the downstream miRNAs and mRNAs of the target circRNAs, and a ceRNA network related to the identified circRNAs was constructed in Cytoscape. Results: Sequencing analysis showed that 366 circRNAs were significantly differentially expressed in OLK tissues, including 65 upregulated and 301 downregulated circRNAs. After qRT-PCR verification, 7 of the 10 screened circRNAs were expressed consistent with the sequencing results. The upregulated circHLA-C was confirmed to be a real circRNA with back-splice junction sites by RNase R digestion and Sanger sequencing. Correlation analysis showed a positive correlation between circHLA-C and the degree of OLK dysplasia. ROC curve analysis suggested that circHLA-C had potential value in diagnosing OLK with high accuracy and specificity. Conclusion CircRNA was significantly abnormally expressed in OLK tissues, and the upregulation of circHLA-C may be related to the degree of OLK dysplasia, providing guiding value for the diagnosis of OLK in the future.