1.A case of sertoli-leydig cell tumor.
Hae Hyeog LEE ; Young Mun HUR ; Chang Hee LEE ; So Young JIN ; Kae Hyun NAM ; Kwon Hae LEE ; Tai Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(2):253-263
No abstract available.
Sertoli-Leydig Cell Tumor*
2.A case of Sertoli-Leydig cell tumor, poorly differentiated.
Eui Yeul LEE ; Ye Gyo LEE ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1991;34(6):892-899
No abstract available.
Sertoli-Leydig Cell Tumor*
3.A case of Sertoli-Leydig cell tumor.
Mi Ja LEE ; Kyoung Suk PARK ; Hee Soo CHUNG ; Hyang Mee KIM ; Eun Hee YOO ; Jung Ja AHN
Korean Journal of Obstetrics and Gynecology 1992;35(4):618-623
No abstract available.
Sertoli-Leydig Cell Tumor*
4.A case of Sertoli-Leydig cell tumor.
Sang Duk SHIM ; Wan Young KIM ; Dae Sik SEO ; Young Min CHOI ; Soon Bum KANG ; Hyo Pyo LEE
Korean Journal of Obstetrics and Gynecology 1992;35(7):1096-1103
No abstract available.
Sertoli-Leydig Cell Tumor*
5.Coincidental finding of Sertoli-Leydig Cell Tumor in a postmenopausal woman with mild hyperandrogenism, ovarian teratoma, and pelvic organ prolapse: A case report
Hermina Silonga-Arce ; Minnou O. Tapia
Philippine Journal of Reproductive Endocrinology and Infertility 2024;21(1):8-13
A Sertoli-Leydig cell tumor (SLCT) is an extremely rare type of sex cord stromal tumor of the
ovary, which mainly secretes testosterone, thus manifestations of hyperandrogenism commonly
appear. This paper shall discuss a case of a postmenopausal woman who presented with pelvic
organ prolapse, large left ovarian cyst and mild signs of hyperandrogenism. She underwent
total abdominal hysterectomy with bilateral salpingo-oophorectomy, which on microscopic
examination of the specimens, revealed a Mature cystic teratoma on the left ovary and an
incidental finding of a well-differentiated SLCT, on the grossly normal-looking ovary. This
histopathologic diagnosis of SLCT explained the patient’s hyperandrogenic characteristics.
Authors likewise discussed the proper management of SLCT, including immunostaining and
need for adjuvant chemotherapy.
Sertoli-Leydig Cell Tumor
6.A Case of Estrogen-producing Sertoli-Leydig Cell Tumor with Precocious puberty.
Myung Sun OH ; Nan Kyoung KIM ; Dae Hyun LIM ; Jeung Hee KIM ; Byong Kwan SON ; In Suk JOO ; Ku Sang KIM ; Young Chai JOO
Journal of the Korean Pediatric Society 1990;33(9):1301-1305
No abstract available.
Puberty, Precocious*
;
Sertoli-Leydig Cell Tumor*
7.A Case of Giant Sertoli-Leydig Cell Tumor of the Ovary with Masculinization.
Korean Journal of Gynecologic Oncology and Colposcopy 2001;12(1):63-67
Sertoli-Leydig cell tumor is a rare sex-cord stromal tumor of the ovary and accounts for less than 0.5% of all ovarian tumors. It is among the most fascinating from pathologic and clinical viewpoints in masculinization. We experience an unusual case of a poorly differentiated Sertoli-Leydig cell tumor in 60-year-old woman who showed masculinization and present it with brief review of literature.
Female
;
Humans
;
Middle Aged
;
Ovary*
;
Sertoli-Leydig Cell Tumor*
8.Pure sertoli cell tumor of the ovary, a rare cause of isosexual pseudoprecocious puberty in a two year old girl
Calderon-Domingo Madona Victoria ; Irabon Ina S
Philippine Journal of Reproductive Endocrinology and Infertility 2009;6(2):68-79
A case of a two and a half year old girl with a 6 month history of isosexual precocious puberty (thelarche: Tanner stage 2 breasts and menarche) secondary to an estrogenizing pure Sertoli cell tumor of the left ovary is presented. Pre-operative tumor markers AFP, BhCG and CA-125 revealed normal results. Transabdominal ultrasound with color flow mapping and Doppler interrogation revealed a solid left ovarian mass probably malignant. The patient underwent exploratory laparotomy, left salpingooophorectomy and frozen section revealing sex cord stromal tumor. Paraffin sections stained with Hematoxylin and Eosin revealed a benign Sertoli cell tumor. Immunostains of the tumor reacted positively for inhibin, calretenin and cytokeratin, but negative for epithelial membrane antigen. Total serum estradiol, prolactin, TSH and LH were elevated prior to surgical operation, with LH and prolactin substantially decreasing four weeks later into the normal prepubertal range. TSH and estradiol levels however have remained very slightly elevated. Serum FSH was at prepubertal levels. Breasts size had likewise regressed to prepubertal size four weeks postoperatively, and the menses never recurred. This is the youngest reported occurrence of this rare sex cord stromal neoplasm in the last 10 years in our institution. The prognosis of this extremely rare tumor presenting at this early juvenile stage is uncertain, and it is recommended to keep a close follow-up and regular endocrinologic investigation until prepubertal values are attained.
SERTOLI
;
CELL TUMOR
;
ISOSEXUAL
;
PRECOCIOUS PUBERTY
;
MENARCHE,
;
THELARCHE
9.Alpha-Fetoprotein Producing Sertoli-Leydig Cell Tumor of the Ovary: A Case Report.
Kee Taek JANG ; Hye Rim PARK ; Duck Hwan KIM ; Chang Mo KIM ; Woo Seok SOHN ; Hyung Sik SHIN
Korean Journal of Pathology 2002;36(2):128-131
A 26-year-old woman had an ovarian Sertoli-Leydig cell tumor (SLCT) associated with an elevated level of serum alpha-fetoprotein (AFP). The tumor had a heterologous element of intestinal-type mucinous epithelium, retiform and intermediately differentiated tubules of the Sertoli cells, and AFP-producing Leydig cells. AFP was demonstrated within the Leydig cells by an immunohistochemical technique. After surgery, the serum AFP level of the patient fell to the normal range. The present case is the first documented case of AFP producing a SLCT of the ovary reported in Korea.
Adult
;
alpha-Fetoproteins*
;
Epithelium
;
Female
;
Humans
;
Korea
;
Leydig Cells
;
Male
;
Mucins
;
Ovary*
;
Reference Values
;
Sertoli Cells
;
Sertoli-Leydig Cell Tumor*
10.On Changes of fine Structures of the Sertoli Cells in the Human Male Sterility.
Korean Journal of Urology 1975;16(2):81-88
Electron microscopic observation of fine structural changes of Sertoli cells in the male sterility patients was made on 10 histologically proved cases. They were histologically classified to 3 groups by Nelson's classification, hypospermatogenesis, spermatogenic arrest and germinal cell aplasia. The results obtained were summarized as follows. l) The findings of ultrastructures of Sertoli cells in the normal man showed no significant differences with other author's results. 2) The ultrastructures of Sertoli cells in the male sterility revealed degenerative changes, characterized by fragmentation and dilatation of subsurface cisternae, swelling and vacuolization of mitochondria with decrease in the number of cristae and poor development of Golgi apparatus. And also observed were proliferative changes, characterized by increase in the number of sER, rER and ribosome. These morphological changes were severer in spermatogenic arrest and the severest in germinal cell aplasia. 3) The results were suggested that the most significant ultrastructural changes of Sertoli cells of male sterility were the degenerative changes of the organelles of protein synthesis and protein transport system such as rER, ribosome and Golgi apparatus.
Classification
;
Dilatation
;
Golgi Apparatus
;
Humans*
;
Infertility
;
Infertility, Male*
;
Male
;
Male*
;
Mitochondria
;
Oligospermia
;
Organelles
;
Protein Transport
;
Ribosomes
;
Sertoli Cell-Only Syndrome
;
Sertoli Cells*