No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

A Sertoli-Leydig cell tumor (SLCT) is an extremely rare type of sex cord stromal tumor of the ovary, which mainly secretes testosterone, thus manifestations of hyperandrogenism commonly appear. This paper shall discuss a case of a postmenopausal woman who presented with pelvic organ prolapse, large left ovarian cyst and mild signs of hyperandrogenism. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, which on microscopic examination of the specimens, revealed a Mature cystic teratoma on the left ovary and an incidental finding of a well-differentiated SLCT, on the grossly normal-looking ovary. This histopathologic diagnosis of SLCT explained the patient’s hyperandrogenic characteristics. Authors likewise discussed the proper management of SLCT, including immunostaining and need for adjuvant chemotherapy.
Sertoli-Leydig Cell Tumor

No abstract available.
Puberty, Precocious* ; Sertoli-Leydig Cell Tumor*

Sertoli-Leydig cell tumor is a rare sex-cord stromal tumor of the ovary and accounts for less than 0.5% of all ovarian tumors. It is among the most fascinating from pathologic and clinical viewpoints in masculinization. We experience an unusual case of a poorly differentiated Sertoli-Leydig cell tumor in 60-year-old woman who showed masculinization and present it with brief review of literature.
Female ; Humans ; Middle Aged ; Ovary* ; Sertoli-Leydig Cell Tumor*

A case of a two and a half year old girl with a 6 month history of isosexual precocious puberty (thelarche: Tanner stage 2 breasts and menarche) secondary to an estrogenizing pure Sertoli cell tumor of the left ovary is presented. Pre-operative tumor markers AFP, BhCG and CA-125 revealed normal results. Transabdominal ultrasound with color flow mapping and Doppler interrogation revealed a solid left ovarian mass probably malignant. The patient underwent exploratory laparotomy, left salpingooophorectomy and frozen section revealing sex cord stromal tumor. Paraffin sections stained with Hematoxylin and Eosin revealed a benign Sertoli cell tumor. Immunostains of the tumor reacted positively for inhibin, calretenin and cytokeratin, but negative for epithelial membrane antigen. Total serum estradiol, prolactin, TSH and LH were elevated prior to surgical operation, with LH and prolactin substantially decreasing four weeks later into the normal prepubertal range. TSH and estradiol levels however have remained very slightly elevated. Serum FSH was at prepubertal levels. Breasts size had likewise regressed to prepubertal size four weeks postoperatively, and the menses never recurred. This is the youngest reported occurrence of this rare sex cord stromal neoplasm in the last 10 years in our institution. The prognosis of this extremely rare tumor presenting at this early juvenile stage is uncertain, and it is recommended to keep a close follow-up and regular endocrinologic investigation until prepubertal values are attained.
SERTOLI ; CELL TUMOR ; ISOSEXUAL ; PRECOCIOUS PUBERTY ; MENARCHE, ; THELARCHE

A 26-year-old woman had an ovarian Sertoli-Leydig cell tumor (SLCT) associated with an elevated level of serum alpha-fetoprotein (AFP). The tumor had a heterologous element of intestinal-type mucinous epithelium, retiform and intermediately differentiated tubules of the Sertoli cells, and AFP-producing Leydig cells. AFP was demonstrated within the Leydig cells by an immunohistochemical technique. After surgery, the serum AFP level of the patient fell to the normal range. The present case is the first documented case of AFP producing a SLCT of the ovary reported in Korea.
Adult ; alpha-Fetoproteins* ; Epithelium ; Female ; Humans ; Korea ; Leydig Cells ; Male ; Mucins ; Ovary* ; Reference Values ; Sertoli Cells ; Sertoli-Leydig Cell Tumor*

PURPOSE: This study investigated the relationship between spermatogenesis and telomerase activity in sperm pellet and testicular biopsy specimen to define the pathophysiology. MATERIALS AND METHODS: PCR-based telomeric repeat amplification protocol(TRAP) assay was used to detect telomerase activity of sperm pellet from 10 normal fertile volunteers, 25 sperm pellet from infertile patients with oligospermia. and 48 testicular tissues from biopsy or orchiectomy followed by various causes. The telomerase activity were compared with the Johnsen score and serum hormonal levels. RESULTS: Any Telomerase activity was not detected in sperm pellet from normal volunteers and 22 of 25 (88%) sperm pellet from infertile patients with oligospermia. In testicular tissues, telomerase activity was expressed in all patients with normal spermatogenesis, while was not expressed in all with Sertoli cell only syndrome. Of one disorganization & sloughing, 15 hypospermatogenesis and 6 maturation arrest, one (100%), 14 (93.3%) and 5 (83.3%) cases expressed telomerase activity. Frequency and density of telomerase activity were increased according to the increasing of Johnsen score, but no statistical significance. Telomerase activity was not related with serum hormone levels including FSH, LH, T, E2 and prolactin. CONCLUSIONS: Telomerase appears to be present in testicular tissue that harbors immature germ cells and is absent in tissue that contains only Sertoli cells. These data indicate that measurement of telomerase activity may be a useful predictor of spermatogenic activity for applicating the assisted reproductive technology including testicular sperm extraction in male infertile patient with Sertoli cell only syndrome.
Biopsy ; Germ Cells ; Healthy Volunteers ; Humans ; Male ; Oligospermia ; Orchiectomy ; Prolactin ; Reproductive Techniques, Assisted ; Sertoli Cell-Only Syndrome ; Sertoli Cells ; Spermatogenesis* ; Spermatozoa ; Telomerase* ; Volunteers