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Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread around the world. However, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet been reported. We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25 (25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was Mycoplasma pneumonia (29, 29.9%). One patient with confirmed COVID-19 died. Our results strongly indicated that the detection of asymptomatic COVID-19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative.
Age Factors ; COVID-19/diagnosis* ; COVID-19 Testing ; Child ; Child, Preschool ; China ; Female ; Hospitalization ; Humans ; Infant ; Male ; Retrospective Studies ; SARS-CoV-2/isolation & purification* ; Symptom Assessment

7.Positive RT-PCR detected in patients recovered from COVID-19.

Glorijoy Shi En TAN ; Ying DING ; Lin CUI ; Tze Minn MAK ; Chee Keng MOK ; Asok KURUP ; Purnima PARTHASARATHY ; Wan Ni CHIA ; Lin Fa WANG ; Raymond T P LIN ; Yee Sin LEO ; Shawn VASOO

Annals of the Academy of Medicine, Singapore 2021;50(2):191-194

8.TTSH and NCID Radiology Services in COVID-19.

Hsien Min LOW ; Eugene LOW ; Chau Hung LEE

Annals of the Academy of Medicine, Singapore 2020;49(11):913-914

9.Deployment of a Forward Medical Post to Provide Medical Support in a Purpose-built Dormitory during the COVID-19 Pandemic.

Guan Lin LEE ; Wei Ting LEE ; Wai Leong KOK

Annals of the Academy of Medicine, Singapore 2020;49(11):928-930

10.Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients.

Mei HAN ; Jing Bo ZOU ; Huan LI ; Xiao Yu WEI ; Song YANG ; Hui Zheng ZHANG ; Peng Sen WANG ; Qian QIU ; Le Le WANG ; Yao Kai CHEN ; Pin Liang PAN

Biomedical and Environmental Sciences 2020;33(12):935-939

1.Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China.

2.Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.

3.Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing.

4.Detecting Environmental Contamination of Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Isolation Wards and Fever Clinics.

5.Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody.

6.Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19.

7.Positive RT-PCR detected in patients recovered from COVID-19.

8.TTSH and NCID Radiology Services in COVID-19.

9.Deployment of a Forward Medical Post to Provide Medical Support in a Purpose-built Dormitory during the COVID-19 Pandemic.

10.Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients.

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