A case of congenital self-healing histiocytosis was studied with S-100 antibody and electron microscopy. Many tumor cells were positive for S-100 protein and a few contained Birbeck´s grandles and dense bodies. A pathlogic fracture was first noticed on the seventh day. The lesions involuted spontaneously by the end of a weeks
Histiocytosis* ; Microscopy, Electron ; S100 Proteins

An immunohistochemical and electron microscopic study of an atypical fibroxanthoma of the skin (AFX) was reported. The lesion developed on the left scapulararea in a 70-year-old man. The result using antibody to S-100 protein was negative and the tumor cells observed with electron microscope were undifferentiated, fibroblast-like, histiocyte-like and multinucleated giant cells. But Langerhans-like cells or Langerhans were not found.
Aged ; Giant Cells ; Humans ; S100 Proteins ; Skin*

A schwannoma is a benign neoplasm that is composed of a relative pure proliferation of Schwann cell and constitutes 1% of orbital tumors. Most series report patient age between 20 and 50 year. There was no case report with the schwannoma of nenonate in the domestic and the abroad except two cases in the childhood age group. We experienced a schwannoma which diagnosed by microscopic and immunohistochemical S-100 protein stain in neonate who does not open his eye and present a case with a review of the literature.
Humans ; Infant, Newborn* ; Neurilemmoma* ; Orbit* ; S100 Proteins

BACKGROUND: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. OBJECTIVE: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. METHODS: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. RESULTS: 1. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. CONCLUSION:MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma.
Diagnosis ; Melanoma* ; Nevus, Pigmented* ; S100 Proteins

We report two cases of multiple neurilemmomas occured in a 17-year-old female and in a 76-year-old male. Both cases were histopathologically confirmed as neurilemmoma and immunohistochemical study showed S-100 protein in the tumor cells of case 1.
Adolescent ; Aged ; Female ; Humans ; Male ; Neurilemmoma* ; S100 Proteins

We report two cases of multiple neurilemmomas occured in a 17-year-old female and in a 76-year-old male. Both cases were histopathologically confirmed as neurilemmoma and immunohistochemical study showed S-100 protein in the tumor cells of case 1.
Adolescent ; Aged ; Female ; Humans ; Male ; Neurilemmoma* ; S100 Proteins

BACKGROUND: Although clinicopathologic characteristics of acral lentiginous melanoma (ALM) is well established, immunohistochemical study on ALM has rarely been reported. OBJECTIVE: Our purpose is to evaluate the usefulness of several immune markers in the diagnosis of ALM. METHODS: An immunohistochemical study was performed on paraffin sections of 20 ALMs using S-100 protein, HMB-45, vimentin, epithelial membrane antigen (EMA), and CAM 5.2. RESULTS: 1. Nineteen (95%) and 16 (80%) out of 20 ALM showed reactivity with S-100 protein and HMB-45, respectively. 2. Melanin bleaching was useful for diagnosing heavily pigmented ALM using both S-100 protein and HMB-45. 3. The immunoreactivity of S-100 protein and HMB-45 did not correlate with tumor thickness or level of invasion of ALM. The intensity of HMB-45 correlated well with the melanin content. 4. One and 2 out of 20 cases stained focally with EMA and CAM5.2 respectively, but these cases stained also with HMB-45 and/or S-100 protein. CONCLUSION: S-100 protein and HMB-45 were relatively sensitive markers for diagnosing ALM. Despite the occasional positivity for the epithelial markers in ALM, all epithelial marker-positive cases stained also with HMB-45 and/or S-100 protein. Therefore, S-100 protein and HMB-45 are very useful markers for diagnosing ALM.
Biomarkers ; Diagnosis ; Melanins ; Melanoma* ; Mucin-1 ; Paraffin ; S100 Proteins ; Vimentin

Palisaded encapsulated neuroma (PEN) is a clinically-distinctive, benign, cutaneous nerve sheath tumor. It usually occurs as a solitary, asymptomatic, skin-colored papule, and commonly affects the face of middle-aged adults. We report a case of PEN which developed on the lower lip of a 44-year-old Korean man. It was a 5mm-sized skin colored papule. Histopathologically, it consisted of uniform, broad, interlacing fascicles of spindle cells and was surrounded by a complete capsule in the dermis. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 protein and neural filaments, whil the capsule of the nodule was positive for epithelial antigen.
Adult ; Dermis ; Humans ; Lip* ; Neuroma* ; S100 Proteins ; Skin

Primary malignant melanoma arising from the ovarian mature cystic teratoma is extremely rare, with only 31 cases have been described in the literature. It is one of the rarest forms of malignant transformation of ovarian mature cystic teratoma and usually develops unilaterally after menopause. Recently, we experienced a case of primary malignant melanoma arising from ovarian mature cystic teratoma in 71-year-old woman. The diagnosis was confirmed by positive immunohistochemical results of S-100 protein and HMB 45. Here we report the rare case with review of literature.
Aged ; Female ; Humans ; Melanoma ; Menopause ; S100 Proteins ; Teratoma

Fibrosarcoma of the kidney is rare and usually developed from renal capsule. In the past, this diagnosis was made more frequently and was easily mistaken for leiomyosarcoma. With improved histochemical techniques and a better understanding of mesenchymal derived tumors, the diagnosis of fibrosarcoma of the kidney is made rarely. Microscopically, this tumor discloses fascicular arrangement and herringbone appearance of spindle cells. Positive immunohistochemistry for vimentin along with nonreactivity of tumor cells for cytokeratin, S-100 protein, actin, and CD34 supported the diagnosis of fibrosarcoma. Herein, we report a case of fibrosarcoma of kidney with a brief review of the literatures.
Actins ; Diagnosis ; Fibrosarcoma* ; Immunohistochemistry ; Keratins ; Kidney* ; Leiomyosarcoma ; S100 Proteins ; Vimentin