A case of congenital self-healing histiocytosis was studied with S-100 antibody and electron microscopy. Many tumor cells were positive for S-100 protein and a few contained Birbeck´s grandles and dense bodies. A pathlogic fracture was first noticed on the seventh day. The lesions involuted spontaneously by the end of a weeks
Histiocytosis* ; Microscopy, Electron ; S100 Proteins

A schwannoma is a benign neoplasm that is composed of a relative pure proliferation of Schwann cell and constitutes 1% of orbital tumors. Most series report patient age between 20 and 50 year. There was no case report with the schwannoma of nenonate in the domestic and the abroad except two cases in the childhood age group. We experienced a schwannoma which diagnosed by microscopic and immunohistochemical S-100 protein stain in neonate who does not open his eye and present a case with a review of the literature.
Humans ; Infant, Newborn* ; Neurilemmoma* ; Orbit* ; S100 Proteins

An immunohistochemical and electron microscopic study of an atypical fibroxanthoma of the skin (AFX) was reported. The lesion developed on the left scapulararea in a 70-year-old man. The result using antibody to S-100 protein was negative and the tumor cells observed with electron microscope were undifferentiated, fibroblast-like, histiocyte-like and multinucleated giant cells. But Langerhans-like cells or Langerhans were not found.
Aged ; Giant Cells ; Humans ; S100 Proteins ; Skin*

BACKGROUND: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. OBJECTIVE: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. METHODS: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. RESULTS: 1. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. CONCLUSION:MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma.
Diagnosis ; Melanoma* ; Nevus, Pigmented* ; S100 Proteins

Primary malignant melanoma arising from the ovarian mature cystic teratoma is extremely rare, with only 31 cases have been described in the literature. It is one of the rarest forms of malignant transformation of ovarian mature cystic teratoma and usually develops unilaterally after menopause. Recently, we experienced a case of primary malignant melanoma arising from ovarian mature cystic teratoma in 71-year-old woman. The diagnosis was confirmed by positive immunohistochemical results of S-100 protein and HMB 45. Here we report the rare case with review of literature.
Aged ; Female ; Humans ; Melanoma ; Menopause ; S100 Proteins ; Teratoma

BACKGROUND: Although clinicopathologic characteristics of acral lentiginous melanoma (ALM) is well established, immunohistochemical study on ALM has rarely been reported. OBJECTIVE: Our purpose is to evaluate the usefulness of several immune markers in the diagnosis of ALM. METHODS: An immunohistochemical study was performed on paraffin sections of 20 ALMs using S-100 protein, HMB-45, vimentin, epithelial membrane antigen (EMA), and CAM 5.2. RESULTS: 1. Nineteen (95%) and 16 (80%) out of 20 ALM showed reactivity with S-100 protein and HMB-45, respectively. 2. Melanin bleaching was useful for diagnosing heavily pigmented ALM using both S-100 protein and HMB-45. 3. The immunoreactivity of S-100 protein and HMB-45 did not correlate with tumor thickness or level of invasion of ALM. The intensity of HMB-45 correlated well with the melanin content. 4. One and 2 out of 20 cases stained focally with EMA and CAM5.2 respectively, but these cases stained also with HMB-45 and/or S-100 protein. CONCLUSION: S-100 protein and HMB-45 were relatively sensitive markers for diagnosing ALM. Despite the occasional positivity for the epithelial markers in ALM, all epithelial marker-positive cases stained also with HMB-45 and/or S-100 protein. Therefore, S-100 protein and HMB-45 are very useful markers for diagnosing ALM.
Biomarkers ; Diagnosis ; Melanins ; Melanoma* ; Mucin-1 ; Paraffin ; S100 Proteins ; Vimentin

Papillary eccrine adenoma is a rare cutaneous tumor which occurs most commonly on the distal portion of extremities as a small solitary nodule. Histopathologically, the tumor consists of multiple dilated or branching tubular structures that are lined by two or more layers of epithelial cells and shows papillary projection into the lumina. Positive staining with S-100 protein, CEA, EMA and keratin in papillary eccrine adenoma is consistent with differentiation toward the secretory epithelium of eccrine sweat gland. Herein we report four cases of papillary eccirine adenoma and review the literature.
Adenoma* ; Epithelial Cells ; Epithelium ; Extremities ; S100 Proteins ; Sweat Glands

Neurilemmoma is rare benign tumor originating from the Schwann cell of the nerve sheath. Intrabronchial neurilemmoma are extremely rare and only few cases have been reported previously in Korea. Neurilemmoma at all ages but are most common in persons between the ages of 20 and 50 years. It affects the head, neck, flexor regions of the extremities. Neurilemmoma was confirmed histologically because of the presence of Verocay bodies, Antoni A or B tissue pattern and of S-100 protein. We report two cases of intrabronchial neurilemmoma with chronic coughing and nonspecific radiologic findings.
Cough ; Extremities ; Head ; Humans ; Korea ; Neck ; Neurilemmoma* ; S100 Proteins

In this paper, we present an extremely rare case of a primary intrapulmonary neurogenic tumor, in which localization of S-100 protein was investigated using immunohistochemical staining. The patient, who was a 47 year old man, experienced no symptoms, however, a routine chest X-ray revealed a round tumor like shadow in the hilar area of left lung. To confirm and cure the mass, surgery was performed. Histopathological examination of the excised tumor revealed it to be a primary intrapulmonary neurilemmoma. Immunohistochemical staining demonstrated the presence of S-100 protein in the tumor cells.
Humans ; Lung ; Lung Neoplasms ; Middle Aged ; Neurilemmoma* ; S100 Proteins ; Thorax

We report two cases of multiple neurilemmomas occured in a 17-year-old female and in a 76-year-old male. Both cases were histopathologically confirmed as neurilemmoma and immunohistochemical study showed S-100 protein in the tumor cells of case 1.
Adolescent ; Aged ; Female ; Humans ; Male ; Neurilemmoma* ; S100 Proteins