1.Effectiveness of Serial Measurement of Differential Pressure in Closed Tibial Diaphyseal Fractures in Diagnosing Acute Compartment Syndrome using Whiteside's Technique
Ramprasath DR ; Thirunarayanan V ; David J ; Anbazhagan S
Malaysian Orthopaedic Journal 2016;10(1):1-4
Acute Compartment Syndrome is a limb-threatening
emergency and it occurs most commonly after fractures. The
aim of our study is to find out the effectiveness of serial
measurement of differential pressure in closed tibial
diaphyseal fractures, in diagnosing acute compartment
syndrome, using Whiteside’s technique. A total of 52 cases in
the age group of 15 to 55 years admitted with closed
fractures were studied for serial compartment pressure as
well as serial differential pressure. Eight patients had
persistent compartment pressure > 40mmHg, out of which
only two patients had persistent differential pressure <
30mmHg and these two patients underwent fasciotomy.
Thus, by measuring the compartment pressure serially and
calculating differential pressure serially, acute compartment
syndrome can be diagnosed or ruled out with higher
precision, so that unnecessary fasciotomies can be avoided.
Tibial Fractures
2.Care, management, and use of ferrets in biomedical research
Ravindran Kumar PRAMOD ; Pravin Kumar ATUL ; Mamta PANDEY ; S. ANBAZHAGAN ; Suhas T. MHASKE ; R. BARATHIDASAN
Laboratory Animal Research 2024;40(1):1-13
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora.The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century.It is a suitable non-rodent model in biomedical research because of its hardy nature, social behavior, diet and other habits, small size, and thus the requirement of a relatively low amount of test compounds and early sexual maturity compared with dogs and non-human primates. Ferrets and humans have numerous similar anatomical, metabolic, and physiological characteristics, including the endocrine, respiratory, auditory, gastrointestinal, and immunological systems. It is one of the emerging animal models used in studies such as influenza and other infectious respiratory diseases, cystic fibrosis, lung cancer, cardiac research, gastrointestinal disorders, neuroscience, and toxicological studies. Ferrets are vulnerable to many human pathogenic organisms, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), because air transmission of this virus between them has been observed in the laboratory. Ferrets draw the attention of the medical community compared to rodents because they occupy a distinct niche in biomedical studies, although they possess a small representation in laboratory research.