1.Turning on the Left Side Electrode Changed Depressive State to Manic State in a Parkinson's Disease Patient Who Received Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Case Report.
Makoto KINOSHITA ; Masahito NAKATAKI ; Ryoma MORIGAKI ; Satsuki SUMITANI ; Satoshi GOTO ; Ryuji KAJI ; Tetsuro OHMORI
Clinical Psychopharmacology and Neuroscience 2018;16(4):494-496
No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.
Aged
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Bipolar Disorder*
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Deep Brain Stimulation*
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Depression
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Electrodes*
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Extremities
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Female
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Humans
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Mood Disorders
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Parkinson Disease*
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Subthalamic Nucleus*
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Tremor
2.Effects of a Mouthwash Containing Plant Extracts on Gingivitis and Halitosis
Koji HATTORI ; Akiko WATANABE ; Hiroshi TAKAGI ; Naokazu HOTTA ; Youichi YASHIRO ; Ryoma GOTO ; Noritaka SAWADA ; Genta YAMAMOTO ; Akio MITANI ; Seiji HASEGAWA
Japanese Journal of Complementary and Alternative Medicine 2023;20(1):1-8
Mouthwash is used to support brushing because it is distributed throughout the oral cavity. In this study, we examined the efficacy of a mixture of three hot water extracts (from Hordeum vulgare L, Apocynum venetum L, and Brasenia schreberi J. F. Gmel) for the purpose of developing an effective mouthwash. The mixture suppressed enhanced tumor necrosis factor α and matrix metalloproteinase 3 gene expression by Porphyromonas gingivalis lipopolysaccharide stimulation in human gingival fibroblasts. Furthermore, human studies using a mouthwash containing the plant extracts (MW) improved gingival index and bleeding on probing in the gum, and reduced the concentration of methyl mercaptan, which causes bad breath, in the mouth. These findings suggest that continued use of MW has positive effects on gingival inflammation and halitosis, and is useful for maintaining oral health.