To clarify the relationship between the occurrence of the attacks of Raynaud's phenomenon and weather, maximum, minimum and mean air temperatures in winter were surveyed on the days in which the attacks of Raynaud's phenomenon occurred in 4 female students with Raynaud's phenomenon in the fingers. The results obtained were as follows:
1) In general, the percentages of the days when the attacks of Raynaud's phenomenon occurred was the highest from the end of November to December, compared to the January and February results.
2) Minimum and mean air temperatures on the days excluding holidays when the attacks of Raynaud's phenomenon occurred were significantly lower than those on the days when the attacks did not occur for the subject who went to school from her own home; this result was not noticeble for the others who lived at the dormitory. In all subjects there were no differences in the maximum air temperatures between the days when the attacks of Raynaud's phenomenon occurred and the days when the attack did not occur.

The present study was carried out on mice and rats to examine the effects of running and swimming on immune responses, particularly IgE antibody and hemagglutinin (HA) production. In the experiment with running mice, four-week old mice were divided into four groups. The first group of mice started running at the age of four weeks (E4 group), the second group started running at the age of seven weeks (E7 group), the third group started running at the age of 10 weeks (E10 group), and the fourth group was a control that received no treatment. In the experiment protocol, each group was subjected to running exercise until the age of 13 weeks. Each group of mice was forced to run at a speed of 15m/min on a flat floor with no slope for 60min a day. In the E4 group, IgE antibody production was suppressed without affecting HA production. In the E7 and E10 groups, neither IgE antibody production nor HA production was affected. In the experiment with swimming rats, seven-week old rats were divided into two groups: the swim group and the control group. The swim group was forced to swim for five days for three 15-min sessions a day loaded with an iron ring weighing 3% of the body weight. The control received no treatment. In the swim group, IgE antibody production was suppressed without affecting HA production. From these results, it might be concluded that running exercise and swimming exercise from early childhood will provide favorable influences on some asthmatic diseases by suppressing IgE antibody production.

The attack of Raynaud's phenomenon (RP) is characterized by finger blanching in response to cold or emotional stimuli.
To clarify the relationship between the attack of RP and air temperature, certain inhabitants of mountain village “T” (N₁=23) who had primary RP (PRP) were observed every day from August 20, 1990 to May 31, 1991 and those in town “K” (N₂=20) were observed from November 1, 1990 to May 31, 1991. One hundred and sixty-seven attacks of RP among 6 subjects in T Village and 89 attacks among 8 subjects in K Town were observed.
In T Village, the frequency of attacks was high in the morning, and the minimum and mean air temperatures in the days when some of the subjects had attacks (“attack days”) were significantly lower than those in the days when there was no attack on any subject (“non-attack days”). In K Town the frequency of attacks was high both in the morning and in the evening. In addition, the, mean and maximum air temperatures on the “attack days” were significantly lower than those on the “non-attack days.” The threshold temperature to cause RP attacks differed from one subject to another (5.2 to 17.6°C) in K Town during the period from November through February. The minimum air temperature which caused an attack of RP on any subject in T Village from August 20 to December 31 was 17.8°C.
These results suggest that cooling of the whole body in daily life promotes the onset of attacks of RP. When the minimum air temperature becomes lower than 18°C from autumn to winter, the whole body must be protected against cold to prevent the onset of RP.

To explore the possibility of incorporating oriental medicine and medical hydrology in the educational programs of medical, nursing and pharmaceutical schools, a questionnaire on the attitude of medical students (group A, N=70; group B, N=77), nursing students (group C, N=64; group D, N=61) and pharmaceutical students (group E, N=172) who had not yet received any practical medical education was circulated. The results showed that about 50% of the students did not recognize the term “medical hydrology, ” and about 10% of them did not recognize the term “oriental medicine.” Seventy-five percent of the group A medical students and 93% of the group B medical students were interested in oriental medicine, and these rates were higher than those who were interested in medical hydrology (49% (67%)). About 50% of the nursing and pharmaceutical students were interested both in oriental medicine and medical hydrology. Eighty-two percent of group A and 86% of group B medical students hoped to attend lectures on oriental medicine, and these rates were higher than those among nursing and pharmaceutical students. Between 49% and 60% of the students of all three groups hoped to attend lectures on medical hydrology. This rate was lower than that of those who hoped to attend lectures on oriental medicine. In general, the rate of those who had a positive image of oriental medicine was higher among medical and pharmaceutical students. However, there were no significant differences in the rates of those who had a positive image of medical hydrology among different groups of students. In all student groups, the rate of those who answered that both oriental medicine and medical hydrology are “relatively effective” was the highest.

A self administered survey on bathing and nearly drowning accidents in the bathtub was conducted among subjects consisting of 216 members of an aged person's club (153 males and 63 females, 73.7±4.9 years of age) for the purpose of utilizing the results for guidance in bathing for elderly persons. The subjects were bathing almost every day. The total bathing time was 20min and the time spent in the bathtub was 11min. With regard to the preference of bathing temperature, 50.4% of males and 33.3% of females answered that they like hot bathing (P<0.05). The ratios of the subjects who bathe at water temperatures over 42°C in the cold season were 39.0% of males and 21.0% of females (P<0.05). Only 4.2% of the subjects bathe below the waist. The ratios of the subjects who frequently bathe after drinking were 9.2% of males and 1.9% of females. The ratio of the subjects who bathe alone at home was 94.1%. The ratios of the subjects in this survey who had nearly drowned in the bathtub while bathing at home was 4.3%. A nearly drowning accident occurred primarily when the subject got fatigued (44.4%) or physical condition of the subject was bad (44.4%). The ratio of the subjects who had nearly drowned in a large bathtub of a hotel was 1.4%. No subjects had experienced a nearly drowning accident in the bathtub of a public bath. These results suggested that old persons, particularly males, bathe under rather unsafe conditions.

Objective: The purposes of this trial were to demonstrate the feasibility and effectiveness of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced cervical cancer patients in the phase I/II prospective clinical trial. Methods: Patients with FIGO stage IB2-IVA uterine cervical cancer pretreatment width of which was ≥5 cm measured by magnetic resonance imaging were eligible for this clinical trial. The protocol therapy included 30–30.6 Gy in 15–17 fractions of whole pelvic radiotherapy concurrent with weekly CDDP, followed by 24 Gy in 4 fractions of HBT and pelvic radiotherapy with a central shield up to 50–50.4 Gy in 25–28 fractions. The primary endpoint of phase II part was 2-year pelvic progression-free survival (PPFS) rate higher than historical control of 64%. Results: Between October 2015 and October 2019, 73 patients were enrolled in the initial registration and 52 patients proceeded to the secondary registration. With the median follow-up period of 37.3 months (range, 13.9–52.9 months), the 2- PPFS was 80.7% (90% confidence interval [CI]=69.7%–88%). Because the lower range of 90% CI of 2-year PPFS was 69.7%, which was higher than the historical control ICBT data of 64%, therefore, the primary endpoint of this study was met. Conclusion The effectiveness of HBT were demonstrated by a prospective clinical study. Because the dose goal determined in the protocol was lower than 85 Gy, there is room in improvement for local control. A higher dose might have been needed for tumors with poor responses.