The Spontaneously Hypertensive Rats (SHR) are in the abnormal situation of the central nervous system, especially in that of the medulla oblongate and pons. By using the Amon point, studies were performed on the relationship between the blood pressure and the dosage, and on the effect of controling the blood pressure of SHR in the prehypertensive stage.
Material and Method
Males in two weeks after birth were divided in three groups (6-8 each) and given a stimulating moxibustion on the Amon point analogus to that of human to SHR. The amount of the stimulation were dosed by the moxa of 0.01g per 10g body weight (BW) in T₁ group that of 0.005g per 10g BW in T₅ group. The control group was free from stimuration.
Result
More generous rise in blood pressure was observed in the stimulated group, especially a favarable result in T₅ group, concerning body weight, both treated groups showed significantly low compared to that of the control untill 129 days after birth. The organ weight of the adrenal and the cerebrum was significantly high in both the treated groups compared to those of the control. By assay of serum catecholamine, adrenaline in T₅ group was significantly low.
Discussion and Conclusion
Stimulating moxibustion was effective to the development of hypertension in SHR in the prehypertensive stage. Histologically, in the lungs of the treated groups, expressly in T₅ group, less fibrirous inframmation was observed. The stimulation may be considered to enhance somehow immunity. The dosage of the stimulation was considered to be not parallel to its effectiveness.

Objective: To determine the appropriate time points to start regular exercise which could reduce age-related anxiety and impaired social behavior. Methods: For this study, 8-week-old male Wistar rats were divided into three groups: no exercise (NoEX), short-term exercise (S-Ex), and long-term exercise (L-Ex) groups. S-Ex-group rats started treadmill exercise at 12 months of age, while L-Ex rats started from at 2 months of age. Exercise rats were forced to walk on the treadmill three times per week, with 1- to 2-day intervals for 10 minutes during the first 2 weeks, at 10 m/min until 17 months of age, and at 8 m/min thereafter. At 19 months of age, behavioral tests were performed to assess the effects of exercise on age-induced behavioral change as well as quantitative polymerase chain reaction were done to uncover the mechanism behind the behavioral changes. Results: Anxiety-like behavior was improved by long-term exercise. Additionally, rats belonging to the S-Ex and L-Ex groups showed improved social behavior and increased curiosity about interesting objects. The qPCR data showed that treadmill exercise suppressed the expression of immediate-early genes in the prefrontal cortex of the aged rats. Conclusion This study suggests that long-term exercise represses early response genes, and in this way, it increases resistance to stress, diminishes anxiety-related behavior, and improves social behavior. These findings underscore the need to consider appropriate time to start exercise to prevent stress induced anxiety related behavior.