Male SHR used in the study were 11 and 24 weeks old.
Each age of male rats were divided in two groups, treatment group and control group, and each group consisted of 7 to 8 animals.
The animal of treatment groups were given a stimulating moxibustion of the Amon point analogus to that of human to SHR.
The amount of the stimulation were dosed by the moxa of 0.5mg per 1 gram body weight in two groups. The control group was free from stimulation.
More generously rise in blood pressure and the suppressed body weight gain were observed in the stimulated group of the 11 weeks after birth (T₁ group).
T₁ group showed significantly low blood pressure compared to that of the control by five days after the stimulation.
The stimulation group in 24 weeks after birth (T₂ group) didn't show the remarkable changes compared to that of the control.
The organ weight of the adrenal and the cerebrum were significantly high in T₁ group compared to that of the control. Result of the fixed quantity to catecholamine in serum in T₁ group didn't show the remarkable changes.
Discussion and Conclusion.
The stimulus by means of moxibustion was effective to the generously rise of blood pressure and to the suppressed body weight gain for the early stage in hypertension but not for the advance stage in hypertension.

The Spontaneously Hypertensive Rats (SHR) are in the abnormal situation of the central nervous system, especially in that of the medulla oblongate and pons. By using the Amon point, studies were performed on the relationship between the blood pressure and the dosage, and on the effect of controling the blood pressure of SHR in the prehypertensive stage.
Material and Method
Males in two weeks after birth were divided in three groups (6-8 each) and given a stimulating moxibustion on the Amon point analogus to that of human to SHR. The amount of the stimulation were dosed by the moxa of 0.01g per 10g body weight (BW) in T₁ group that of 0.005g per 10g BW in T₅ group. The control group was free from stimuration.
Result
More generous rise in blood pressure was observed in the stimulated group, especially a favarable result in T₅ group, concerning body weight, both treated groups showed significantly low compared to that of the control untill 129 days after birth. The organ weight of the adrenal and the cerebrum was significantly high in both the treated groups compared to those of the control. By assay of serum catecholamine, adrenaline in T₅ group was significantly low.
Discussion and Conclusion
Stimulating moxibustion was effective to the development of hypertension in SHR in the prehypertensive stage. Histologically, in the lungs of the treated groups, expressly in T₅ group, less fibrirous inframmation was observed. The stimulation may be considered to enhance somehow immunity. The dosage of the stimulation was considered to be not parallel to its effectiveness.

OBJECTIVE: Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/high-risk cervical cancer after radical surgery in Japan. METHODS: A questionnaire survey was conducted by the Japanese Gynecologic Oncology Group to 186 authorized institutions active in the treatment of gynecologic cancer. RESULTS: Responses were obtained from 129 facilities. Adjuvant RT/CCRT and intensity-modulated RT were performed in 98 (76%) and 23 (18%) institutions, respectively. On the other hand, CT was chosen as an alternative in 93 institutions (72%). The most common regimen of CT, which was used in 66 institutions (51%), was a combination of cisplatin/carboplatin with paclitaxel. CT was considered an appropriate alternative option to RT/CCRT in patients with risk factors such as bulky tumors, lymph node metastasis, lymphovascular invasion, parametrial invasion, and stromal invasion. The risk of severe adverse events was considered to be lower for CT than for RT/CCRT in 109 institutions (84%). CONCLUSION: This survey revealed a variety of policies regarding adjuvant therapy among institutions. A clinical study to assess the efficacy or non-inferiority of adjuvant CT is warranted.
Chemoradiotherapy, Adjuvant ; Combined Modality Therapy ; Female ; Humans ; Japan/epidemiology ; Middle Aged ; Neoplasm Recurrence, Local/prevention & control ; *Practice Patterns, Physicians'/statistics & numerical data ; Risk Assessment ; Risk Factors ; Surveys and Questionnaires ; Uterine Cervical Neoplasms/radiotherapy/*therapy

We present a case of redo aortic valve replacement (AVR) in a 71-year-old man with a Lillehei-Kaster valve implanted 42 years prior. The patient initially underwent AVR and open mitral commissurotomy procedures for aortic regurgitation complicated with mitral stenosis in 1978 at the age of 29. Thereafter, he was followed at our outpatient clinic and treated without anticoagulant therapy for the initial two decades of the postoperative period. During the long-term follow-up, the mean pressure gradient remained between 40 and 60 mmHg and there were no adverse events noted before occurrence of heart failure triggered by tachycardia and pneumonia. Following improvement of heart failure, redo AVR was performed. There was no structural damage, thrombosis, or Lillehei-Kaster valve opening restrictions, though severe pannus growth on the left ventricle side was observed, which was thought to be the cause of the increased pressure gradient. This is the first known report of redo AVR after many years in a patient who underwent Lillehei-Kaster valve implantation. Furthermore, no other study has noted findings regarding pressure gradient change during the long-term follow-up period in such cases.

Takayasu Arteritis causes annuloaortic ectasia and coronary ostial stenosis, which may necessitate open heart surgery. However, pseudoaneurysms are sometimes observed postoperatively, making subsequent treatment difficult. We report thoracic endovascular aortic repair of a pseudoaneurysm of the ascending aorta with an anastomosis of the great saphenous vein in a 61-year-old female with a history of multiple open-heart procedures. Thirty years earlier, she underwent aortic valve replacement and coronary artery bypass surgery for aortic regurgitation, and right coronary ostial stenosis. Eleven years after surgery, an ascending aortic aneurysm was found and Bentall's surgery was performed. Multiple open thoracotomies were subsequently performed. Postoperatively, a pseudoaneurysm was found at the anastomosis between the ascending aorta and the great saphenous vein. The patient was transferred to the emergency room owing to hemoptysis and was diagnosed with a ruptured pseudoaneurysm at the anastomosis of the ascending aorta and the great saphenous vein. By inserting a stent graft into the ascending aorta, we avoided further complications and her prognosis was good. She was discharged on postoperative day 18 and did not experience any end leak for a year. Thoracic endovascular aortic repair in the ascending aorta is a minimally invasive procedure that may be useful for high-risk patients.

We report a case of a 49-year-old woman who presented with 6-month period menopausal syndrome including excessive sweating and hot flushes in her face, chest and back. She was also frustrated with her sons, but she reflected on her own anger and wondered why she got so irritated with them. We prescribed yokukansan to her and her all symptoms improved one month later. We need to differentiate between yokukansan and kamishoyosan in the treatment of menopausal syndrome and irritation, and it may be useful to evaluate the detail of irritation in selecting formula.

We report a case of redo mitral valve replacement (MVR) for a Björk-Shiley Delrin valve implanted 47 years previously. A 71-year-old man initially underwent MVR for mitral regurgitation at our hospital at the age of 16 years. Following the operation, follow-up examinations were performed at the outpatient clinic and annual transthoracic echocardiogram findings showed only mild mitral regurgitation, with no adverse events noted. However, a transthoracic echocardiogram examination performed 45 years after the operation revealed mild to moderate mitral regurgitation, while dyspnea with exertion was also noted at that time. As part of a more detailed examination, transesophageal echocardiogram results showed moderate transvalvular leakage. Redo MVR was subsequently performed under the diagnosis of prosthetic valve dysfunction. Analysis of the explanted prosthetic valve revealed wear of the Delrin disk, and widening of the gap between the disk and strut, which were presumed to be the cause of transvalvular leakage. A half century has passed since introduction of the Björk-Shiley valve and the present is a rare case of valve malfunction. Presented here are related details, along with a review of existing literature and results of Björk-Shiley valve use at our hospital.