Humans ; Siblings ; Gene Frequency ; Microsatellite Repeats

Objective:To analyze the gait characteristics of freezing of gait (FOG) in patients with Parkinson's disease (PD).Methods:One hundred and four patients with PD, admitted to our hospital from January 2019 to November 2020, were enrolled in our study. Based on whether patients were accompanied by FOG or not, these patients were divided into PD with FOG group ( n=46) and PD without FOG group ( n=58). "JiBuEn" gait analysis system was used in gait data collection. The gait performance of patients from PD with FOG group was analyzed from 4 perspectives, spatiotemporal parameters, kinematic parameters, and variability and symmetry analyses of gait parameters. Results:As compared with PD without FOG group, PD with FOG group demonstrated a decrease in stride length and gait velocity, an increase in stride length variability, stride time variability, stance-phase time variability and swing phase time variability, with significant differences ( P<0.05). In addition, the heel-strike angle, toe-off angle, range of motion of ankle joint, range of motion of knee joint and range of motion of hip joint in PD with FOG group were significantly decreased as compared with those in PD without FOG group ( P<0.05). Stride length asymmetry index in PD with FOG group was significantly increased as compared with that in the PD without FOG group ( P<0.05). Conclusion:PD patients with FOG mainly exhibit shorter stride length, slower gait velocity, more variable gait pattern and more significant impairment in kinematic parameters than those without FOG.

Objective:To investigate the current situation and influencing factors of patients′ satisfaction with nursing humanistic care, and to provide reference for improving the quality of such care provided by hospitals.Methods:From July to August 2022, outpatients and inpatients in 30 provinces were selected by multi-stage stratified sampling as the survey objects. A cross-sectional survey was conducted on an online platform, using the general information questionnaire and Chinese version of methodist health care system nurse caring instrument revised by the research group. The latter instrument consists of 12 dimensions. namely care coordination, competence, teaching/learning, emotional support, respect for individuality, physical comfort, availability, helping/trusting relationship, patient/family engagement, physical environment, spiritual environment and outcomes. Descriptive analysis was performed on the data collected by the questionnaires, and independent sample t-test and one-way ANOVA were used to analyze the influencing factors of patient satisfaction. Results:A total of 107 hospitals were selected for questionnaire survey, including 86 tertiary hospitals and 21 secondary hospitals, and 29 108 valid questionnaires were recovered. The patient satisfaction with nursing humanistic care scored (5.40±0.86); the top three dimensions were competence (5.50±0.89), emotional support (5.47±0.88) and helping/trusting relationship (5.46±0.86); the lowest scoring dimensions were teaching/learning (5.38±1.01), spiritual environment (5.36±1.04) and patient/family engagement (5.11±1.28). Differences with gender, age, marital status, child status, educational level, occupation, place of residence, economic region, per capita monthly income of the family, type of medical insurance, medical department visited and surgery or not presented significant differences on the patient satisfaction with nursing humanistic care scores ( P<0.05). Conclusions:The satisfaction of patients with hospital′s nursing humanistic care in China was at the middle to upper level. In the future, health education for patients should be strengthened, and a mode of family-engaged nursing humanistic care should be constructed in line with the Chinese cultural background. In the process of nursing services, the particularity of patient groups should be considered to better meet their needs.