Objective To analyse the CT,MRI features of pleomorphic xanthoastrocytoma and improve the diagnosis.Methods Imaging feature of pleomorphic xanthoastrocytoma of 26 cases confirmed by surgery and pathology were analyzed retrospectively.Distribution,size,shape,signal,dense,peritumor edema and invasion of adjacent structures of lesion were summarized.Results The locations of lesions included:temporosphenoid lobe (19 cases),frontal lobe (2 cases),the lateral and three ventricles in 1 case,occipital lobe (1 case),medulla oblongata (1 case),and cervical cord (1 case).The tumor size:maximum:82 mm × 40 mm × 70 mm,minimum:16 mm × 13 mm × 14 mm.Solid lesions (3 cases),solid lesions with necrosis (7 cases),solid and cystic lesions (16 cases),lesion with calcification (4 cases).The solid lesions of the tumors showed equal signal intensity or slightly low signal intensity on T1WI,and equal signal intensity or slightly high signal intensity on T2WI.The equidensite and high density on CT,peritumor edema degree:mild (2 cases),moderate (5 cases),severe (1 case).Conclusion The characteristic imaging features can help in the understanding and diagnosis of pleomorphic xanthoastrocytoma.

Objective:To analyze the gait characteristics of freezing of gait (FOG) in patients with Parkinson's disease (PD).Methods:One hundred and four patients with PD, admitted to our hospital from January 2019 to November 2020, were enrolled in our study. Based on whether patients were accompanied by FOG or not, these patients were divided into PD with FOG group ( n=46) and PD without FOG group ( n=58). "JiBuEn" gait analysis system was used in gait data collection. The gait performance of patients from PD with FOG group was analyzed from 4 perspectives, spatiotemporal parameters, kinematic parameters, and variability and symmetry analyses of gait parameters. Results:As compared with PD without FOG group, PD with FOG group demonstrated a decrease in stride length and gait velocity, an increase in stride length variability, stride time variability, stance-phase time variability and swing phase time variability, with significant differences ( P<0.05). In addition, the heel-strike angle, toe-off angle, range of motion of ankle joint, range of motion of knee joint and range of motion of hip joint in PD with FOG group were significantly decreased as compared with those in PD without FOG group ( P<0.05). Stride length asymmetry index in PD with FOG group was significantly increased as compared with that in the PD without FOG group ( P<0.05). Conclusion:PD patients with FOG mainly exhibit shorter stride length, slower gait velocity, more variable gait pattern and more significant impairment in kinematic parameters than those without FOG.

Humans ; Phosphorylation ; Serine/metabolism* ; Protein Serine-Threonine Kinases/metabolism* ; Signal Transduction ; Neovascularization, Pathologic