Temporal lobe epilepsy (TLE) is the most common clinical type of epilepsy,which is generally available for drug therapy.Surgical operation will be considered when patients developing into refractory epilepsy.Currently,treatment response evaluation is based on the observation of seizure remission in a certain period,and the real-time and objective evaluation is unavailable.With the improvement of MRI technology and image analysis methods,the multimodal MRI has been widely used to assess the effectiveness of TLE treatment.The progresses of multi-modal MRI and its new technique in assessment of epilepsy remission and cognitive function in TLE patients were reviewed in this article.