Objective To explore the effect of hand grip ball exercise on limb function after surgery of breast cancer. Methods 69 patientsafter breast cancer operation were divided into control group (n=35) and observation group (n=34). The control group received regularrehabilitation exercise, and the observation group received nursing intervention based on hand grip ball exercise at the early stage. The effectswere compared between 2 groups 2 months after surgery. Results The patients with arm edema and shoulder function limitation wereless in the observation group than in the control group (P<0.05). Conclusion The application of grasping bounce ball during early rehabilitationstage can facilitate the recovery of breast cancer patients after operation.

目的：探讨手术治疗痉挛型脑瘫的疗效。方法：同期随机采用下肢肌／肌腱切断、闭孔神经前枝切除术（A组）和肌腱／肌切开延长术和闭孔神经前枝切除术（B组）两种方法治疗痉挛型脑瘫下肢畸形共96例，术后功能锻炼，随访3年。进行疗效分析和χ2检验。结果：临床评估优、良、改善率为，A组分别为21．43％、51．43％、27．14％。B组分别为24．62％、57．69％、7．69％。结论：手术治疗痉挛型脑瘫下肢畸形疗效较好，并以B组方式更优。

Objective:To probe the application and the effect of integration medical health education mode in the care-givers of children with capillary bronchitis. Method:Total 120 cases of capillary bronchitis caregivers were divided into control group (56 cases) and observation group (64 cases) and control group with traditional mode of health education, observing group adopts the integration medical health education mode;Compared two groups of children with hospitaliza-tion days, take care of health education knowledge of cooperation degree, satisfaction and health care work. Results:After implementation the integration medical health education mode, children hospitalization days declined. Caregivers' health education knowledge and satisfaction were obviously improved. The medical work cooperation degree is higher than the control group. Conclusions:The implementation of the new mode is helpful to improve work efficiency, reduce the finan-cial burden on families, and meet the demand of caregivers, health education and the right to know and sublimation of medical humanism philosophy, promoting the comprehensive qualities of nurses, improve patient satisfaction, harmonious relationship between hospital and patients, improve high quality nursing care for patients.

Objective:To investigate the influencing factors of quality of life (QOL) in rectal cancer patients with long-term sur-vival (LTS). Methods:A total of 107 patients with stageⅡandⅢrectal cancers were enrolled in this study. Questionnaires were used to determine the clinical factors affecting the QOL of rectal cancer patients with LTS. Results:Physical, emotional, social, and sexual functions were better in patients without colostomy than in those who underwent surgery. However, bowel function was worse in pa-tients who did not undergo surgery (P<0.05). A decrease in social function and QOL was observed in patients who underwent more treatments, and fatigue and insomnia symptoms were more obvious (P<0.05). Logistic regression analysis indicated that treatment was an independent predictor of QOL and negatively correlated with QOL. Conclusion:Treatment is an independent predictor of QOL in patients with stageⅡandⅢrectal cancers, and is negatively correlated with QOL. Surgery is a major factor that affects patient QOL. Improvement of medical technology and reasonable chemoradiotherapy should ameliorate the QOL of patients with LTS.

Objective To study the association of serum cartilage oligomeric matrix protein (COMP)with disease activity and early joint destruction of rheumatoid arthritis (RA). Methods The serum levels of COMP were measured with ELISA in 94 patients with RA and 40 controls. The serum level of erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (ACCP) and hand X-ray were examined at the same time. Results Significantly increased serum level of COMP was found in RA patients (11.3±5.2) U/L as compared to that in healthy controls (9.2±1.7) U/L (P=0.017).Serum level of COMP was higher in 64 active patients (14±6) U/L than that in 30 inactive disease (9±4) U/L(P=0.005). COMP level was positively correlated with the number of the affected joints, X-ray stage, CRP and ESR level (P<0.05); but had no correlation with age, disease course, grade of joint function, RF and ACCP levels. Thirty patients were followed for two years and their radiographic changes were evaluated at the baseline and the end of this study. Sixteen of 18 patients with high concentration serum COMP level had radi-ologic progression, but only 5 of 12 patients with no increase of serum COMP had radiologic progression. A significant difference (P=0.013) was founded in the two groups. Conclusion The present data suggests that the level of COMP is high in patients with RA. High serum levels of COMP indicate high disease activity and early progressive of bone destruction in RA patients. We can us COMP as a laboratory marker of RA.

Objective To measure the serum levels of TWEAK and survivin in rheumatoid arthritis (RA)patients and explore their clinical value. Methods The serum levels of TWEAK and survivin were measured by ELISA methods in 61 patients with RA and 35 healthy controls. The function stage, X-ray stage,and serum levels of ESR, RF and CRP were measured at the same time. Results There was no significant difference between the serum levels of TWEAK in patients with RA[(479±381)pg/ml]and control[(421±87 pg/ml]. The serum level of survivn in patients with RA[(159±82)pg/ml]was increased significantly than that of the controls[(119±24)pg/ml]and were associated with X-ray stage. Conclusion We need further research to explore the relationship between TWEAK and RA. The serum level of survivin is associated with chronic erosive RA and maybe a target for new therapeutic approach of RA.

Objective To investigate the expression of peripheral programmed death (PD)-1hiCXCR5-CD4+T cells and its clinical significance in systemic lupus erythematosus (SLE). Methods Peripheral blood PD-1hiCXCR5-CD4+ T cells from 21 SLE patients and 16 healthy controls were examined by flow cytometry. The levels of serum anti-double-stranded deoxyribonucleic acid (dsDNA) antibodies were determined using immunoradiometric as-say. Data were analyzed with t test and Pearson's correlation test. Results The per-centages of PD-1hiCXCR5- cells within CD4+ T cell were significantly higher in SLE patients [(2.1 ±2.0)％] compared to normal controls [(0.3±0.3)％] (t=2.959, P<0.01). The percentages of PD-1hiCXCR5-cells within CD4+T cells in moderate to severe active SLE patients (3.0 ±2.0)％ was significantly increased compared to patients with mild or inactive (1.0±1.4)％(t=2.574, P<0.05) and normal controls (0.3±0.3)％ (t=5.149, P<0.01). The percentages of PD-1hiCXCR5- cells within CD4+ T cells from SLE patients were positively related with systemic lupus erythematosus disease activity index (SLEDAI) (r=0.475, P=0.0297). SLE patients in serum anti-dsDNA antibodies positive group (2.7±2.1)％displayed a higher percentage of PD-1hiCXCR5-cells within CD4+T cells than patients in serum anti-dsDNA antibodies negative group (0.6 ±0.5)％ (t=2.303, P<0.05). The percentages of PD-1hiCXCR5-cells within CD4+T cells from SLE patients were positively correlated with anti-dsDNA antibody titers. Conclusion The percentages of PD-1hiCXCR5- cells within CD4+ T cells from SLE patients are increased and are positively correlated with SLEDAI and anti-dsDNA antibody levels. Increased percentage of PD-1hiCXCR5-cells within CD4+T cells might play an important role in the pathogenesis of SLE.