1.Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: a randomized controlled trial.
Lu YU ; Shuimiao LIN ; Ruqian ZHOU ; Weijun TANG ; Pinxian HUANG ; Ying DONG ; Jian WANG ; Zhihua YU ; Jiulin CHEN ; Li WEI ; Sanli XING ; Huijuan CAO ; Hongbin ZHAO
Journal of Integrative Medicine 2012;10(7):766-76
Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by its gradual progression. At present, the cause and mechanism of AD are yet unclear, and there is no effective therapy for treating it. With development of global aging, the prevalence rate of AD is increasing. The life quality of elderly people is affected severely by AD that is ultimately life-threatening. Recently, study on treating AD with traditional Chinese medicine (TCM) has deepened.
2.IL-22 and immunity in female reproductive tract
Ruqian ZHAO ; Yuqin ZANG ; Huanrong LI ; Shiqi LIU ; Yingmei WANG ; Fengxia XUE
Chinese Journal of Microbiology and Immunology 2023;43(4):322-326
IL-22 is a member of IL-10 cytokine family. In recent years, increasing evidence has shown that IL-22 is closely related to the immunity in female reproductive tract, and its role in disease development is two-sided. It can not only maintain the balance of microbiota, enhance the resistance to pathogens and reduce the tissue damage caused by infection, but also promote the development and progression of malignant diseases via various signaling pathways. More studies on the biological characteristics and functions of IL-22 are needed for clarifying the pathogenic mechanism and providing new insight into the diagnosis and treatment of female reproductive tract diseases.
3.Progress of adipokines in cancer treatment
Yuqin ZANG ; Ruqian ZHAO ; Shiqi LIU ; Yingmei WANG ; Fengxia XUE
Cancer Research and Clinic 2023;35(5):389-393
Obesity is a well-known high-risk factor for many kinds of neoplasms. Adipokines secreted by adipose tissue play an important role in the process of obesity promoting tumorigenesis and development, and different adipokines play a role in promoting or suppressing cancer via different signaling pathways. Currently, lifestyle modification to control weight and targeted therapy of adipokines and their receptors are major research directions of cancer treatment, but most of the studies are still in the stage of basic and pre-clinical research. Therefore, the molecular mechanisms of adipokines in promoting or suppressing cancer should be further explored, and the dual inhibitors as well as combined therapy are the key research strategies for adipokines in cancer treatment in the future.