With in-depth study of early-stage Breast cancer patients with axillary treatment,SLNB will be able to pro-vide accurate axillary lymph node staging with ALND similar prediction of cancer metastasis. Both of SLNB and ALND were no significant difference in the local recurrence rate,disease-free survival and overall survival, while SLNB can significantly reduce postoperative complications. The use of SLNB will be broader. In this paper, recent progress on SLNB were reviewed.