Objective To investigate the feasibility of spin-echo echo-planar imaging(SE-EPI) of magnetic resonance elastography (MRE) for the diagnosis of pancreatic mass and to evaluate the difference of stiffness value in different pancreatic mass. Methods In a retrospective study, MRE was performed in 20 healthy volunteer (control group) and 62 patients with surgery-proved pancreatic masses, including pancreatic cystadenoma in 5 cases and solid masses of pancreas in 57 cases (39 with malignant mass and 18 with benign mass) using 3.0 T MRE. The differences of stiffness between two groups were evaluated using non-parametric Mann-Whitney U test. ROC was used to assess the diagnostic ability of elastogram for the detection of pancreatic masses, and to evaluate MRE-determined stiffness for the differentiation of masses from healthy pancreas, and malignancy from benign solid masses. Results The total detection rate of elastogram was 91.9%(57/62),with false positive rate of 5.0%(1/20) and false negative rate of 8.1%(5/62). The median stiffness value in the control group vs patient group were 1.18 kPa (interquantile range:1.15 to 1.30) kPa and 2.43 kPa (interquantile range:1.94 to 3.64 kPa) respectively, with statistically significant differences (Z=-5.967,P<0.01). The sensitivity and specificity of stiffness (≥1.36 kPa) to differentiate pancreatic mass from healthy pancreas was 93.6%and 100.0%, respectively, and to differentiate benign and malignant solid masses (≥2.17 kPa) was 82.1%and 83.3%, respectively. Conclusion MRE is a promising method in detecting and distinguishing different pancreatic masses.

Objective To explore the value of 3.0T MR elastography (MRE) in diagnosis of obstructive chronic pancreatitis.Methods Totally 32 patients (lesion group) with suspected obstructive chronic pancreatitis who underwent pancreaticoduodenectomy and 32 volunteers (normal control group) were enrolled.MRE was performed,and pancreatic stiffness value was measured.The consistency between two observers and the repeatability of the same observer were evaluated.The difference of pancreatic stiffness value was compared between the two groups.The efficacy of pancreatic stiffness value in diagnosis of obstructive chronic pancreatitis was analyzed with ROC curve.Results The consistency between two observers and the repeatability of the same observer were excellent (all ICC＞0.9).The pancreatic stiffness value of normal control group and lesion group was (1.21±0.11)kPa and (1.51±0.24)kPa,respectively (t=-6.077,P ＜0.001).The area under ROC curve of pancreatic stiffness value in diagnosis of chronic pancreatitis,mild and moderate to severe,mild to moderate and severe was 0.900,0.941 and 0.960,respectively (all P＜0.001).Conclusion MRE can objectively measure pancreatic stiffness and noninvasively assess the severity of chronic pancreatitis.

Objective:To establish the quality evaluation method of Perillae caulis formula granules based on the three kind of quality indexes of standard decoction. Methods:Eighteen batches of Perillae caulis were collected from different habitats according to different technical requirements, eighteen batches of standard decoction and three batches of formula granules were prepared and the paste-forming rates were calculated. The content of Caffeic acid and Rosmarinic acid were determined and calculated by Ultra High Performance Liquid Chromatography (UPLC). Then the fingerprints of standard decoction of and formula granules of Perillae caulis were established by UPLC . The similarity values of fingerprints between formula granules and standard decoction were calculated. Results:The average paste-forming rate of standard decoction was (7.16±1.97)%. The paste-forming rates of three batches of formula granules were 5.52%, 5.25% and 5.34%, respectively. The average content of Caffeic acid and Rosmarinic acid in standard decoction was (12.06±3.37)mg/g. The contents of three batches of formula granules were 5.52, 5.82, 5.77 mg/g, respectively. Seven common fingerprint peaks were identified in the fingerprints of standard decoction and formula granules, three of which were identified as Caffeic acid, N-Feruloyl Octopus amine and Rosmarinic acid by comparison of reference substance. The fingerprints similarity of Perillae caulis dispensing granules and standard decoction were 1.000, 0.995 and 0.997, respectively. Conclusions:The quality indexes of three batches of formulation granules are consistent with standard decoction. This method can provide basis for the establishment of quality standard of Perillae caulis dispensing granules.

To improve the diagnosis and treatment for tuberous sclerosis complex (TSC) with pulmonary lymphangioleiomyomatosis, a retrospective analysis was performed based on the clinical data of 2 patients with such disease. Both of them have typical thin-walled cystic lesion throughout the lung field, renal angioleiomyolipoma, and various degrees of skin lesions. Central nervous system is involved in one patient. Lesions in the lung and kidney in one patient were improved significantly after 5 months of rapamycin treatment. The clinical phenotypes were diverse in TSC patients. The CT imaging showed typical characteristics when the lung was invaded by the tumor. When a patient was diagnosed as pulmonary lymphangioleiomyomatosis, we should pay attention to the clinical screening of TSC. Rapamycin is an effective and safe treatment for this disease.
Humans ; Kidney ; Lung ; Lung Neoplasms ; Lymphangioleiomyomatosis ; Retrospective Studies ; Tuberous Sclerosis