1.Overview of design and construction of hypertensive disorders of a pregnancy-cohort in Shenzhen
Yixuan CHEN ; Linlin WU ; Xiaoxia WU ; Liying YANG ; Jiaqi XU ; Ling WANG ; Zhaoyang JIANG ; Jingna YAO ; Danni YANG ; Ning SUN ; Jing ZHANG ; Yiwei ZHANG ; Ruowang HU ; Ying LIN ; Kui HUANG ; Bin LI ; Jianmin NIU
Chinese Journal of Epidemiology 2023;44(12):1858-1863
Hypertensive disorder of pregnancy (HDP) involves two major public health issues: mother-infant safety and prevention and controlling major chronic disease. HDP poses a serious threat to maternal and neonatal safety, and it is one of the leading causes of maternal and perinatal morbidity and mortality worldwide, as well as an important risk factor for long-term cardiovascular disease (CVD). In order to explore effective strategies to prevent and control the source of CVD and reduce its risk, we have established a cohort of HDPs in Shenzhen for the primordial prevention of CVD. The construction of the HDP cohort has already achieved preliminary progress till now. A total of 2 239 HDP women have been recruited in the HDP cohort. We have established a cohort data management platform and Biobank. The follow-up and assessment of postpartum cardiovascular metabolic risk in this cohort has also been launched. Our efforts will help explore the pathophysiological mechanism of HDP, especially the pathogenesis and precision phenotyping, prediction, and prevention of pre-eclampsia, which, therefore, may reduce the risk of adverse pregnancy outcomes, and provide a bridge to linking HDP and maternal-neonatal cardiovascular, metabolic risk to promote the cardiovascular health of mothers and their infants.
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