1.Association of polymorphisms of miR-146a rs2910164 locus with clinical features of rheumatoid arthritis.
Qiuxia HU ; Bo LI ; Ruonan SHE ; Ximei WU ; Jinhui TAN ; Jianyun HU ; Qunfang TANG
Chinese Journal of Medical Genetics 2019;36(5):505-507
OBJECTIVE:
To assess the association of single nucleotide polymorphisms (SNPs) of microRNA-146a (miR-146a) with clinical features of rheumatoid arthritis (RA).
METHODS:
In 126 patients with RA and 102 matched healthy controls, SNPs of miR-146a rs2910164 locus were determined with a high-resolution melting method. The association of such polymorphisms with disease activity score in 28 joints (DAS28) and clinical features of RA was assessed.
RESULTS:
The distribution of SNPs of miR-146a rs2910164 among RA patients did not differ from that of the control group. No significant association was found between miR-146a rs2910164 polymorphism with DAS28. However, RA patients with a GG genotype had a greater chance to develop extra-articular manifestations (P<0.01).
CONCLUSION
Polymorphisms of miR-146a rs2910164 locus is not an independent risk factor for RA, though its GG genotype may be associated with extra-articular manifestations of RA.
Arthritis, Rheumatoid
;
genetics
;
Case-Control Studies
;
Genetic Predisposition to Disease
;
Genotype
;
Humans
;
MicroRNAs
;
genetics
;
Polymorphism, Single Nucleotide
2.Levels and influencing factors of perfluorinated and polyfluoroalkyl substances in umbilical cord serum from Sheyang Mini Birth Cohort Study, Jiangsu Province
Ruonan TAN ; Zheng WANG ; Jiming ZHANG ; Yiming DAI ; Jianqiu GUO ; Xiaojuan QI ; Dasheng LU ; Xiuli CHANG ; Chunhua WU ; Zhijun ZHOU
Journal of Environmental and Occupational Medicine 2024;41(8):841-848
Background Perfluorinated and polyfluoroalkyl substances (PFAS), a large group of emerging pollutants, are ubiquitous in the ecological environment. Their multiple organ toxic effects on human body are reported. Understanding the exposure level of PFAS in cord serum and associated influencing factors can provide scientific evidence for studying maternal and newborn health effects and risk regulation. Objective To explore the exposure levels of PFAS in cord serum and potential impact factors. Methods This study was based on the maternal and infant database and the cord serum sample bank of the Sheyang Mini Birth Cohort Study (SMBCS) established in 2009. A self-designed questionnaire was used to collect information on sociodemographic characteristics, living environment, and lifestyle of mothers during pregnancy. A total of