1.Novel 16-slice mobile CT head scan in 391 patients
Zhiqiang ZHANG ; Qiusheng DAI ; Fei LI ; Fei GAO ; Yaxin JING ; Ruonan BI ; Zhenfang WANG ; Rongrong CHEN ; Lida XU ; Daiqiang YIN ; Zhonghua YU ; Qiang ZHANG ; Ruxiang XU
Chinese Journal of Neuromedicine 2018;17(2):184-188
Objective To discuss the application of self-developed novel 16-slice mobile CT head scan.Methods A total of 391 patients were performed 16-slice mobile CT scan:145 were scanned in the emergency department,156 in the neurosurgical ICU,55 in the operated room,and 35 in the ambulance vehicle.Sixty-eight patients were with brain injury,122 were with cerebral hemorrhage,120 were with cerebral infarction,59 were with brain tumors,and 22 were with hemifacial spasm.Thirty-five patients were randomly selected from 391 patients and 8-slice mobile CT head scan was performed on them,which included 12 with brain injury,6 with cerebral hemorrhage,12 with cerebral infarction,3 with brain tumors and 2 with hemifacial spasm.The resolution,imaging quality,radiation doses,power consumption and performance stability of novel 16-slice mobile CT and 8-slice mobile CT head scan were compared.Results The resolution line pairs of brain tissues were 91 p/cm by 16-slice mobile CT and 71 p/cm by 8-slice mobile CT,respectively.The imaging quality of the two kinds of mobile CT head scans was high level to the clinic diagnostic criteria.The radiation dose of 16-slice mobile CT were 40.43 mGy,which decreased by 51.01% as compared with that of 8-slice mobile CT (82.52 mGy).The personal power consumption of 16-silce mobile CT (0.29 kW· h) decreased by 38.30% as compared with those of 8-layer mobile CT (0.47 kW· h).The 16-slice mobile CT kept regularly,while 8-slicer mobile CT stopped to work twice during clinical trial.Conclusion The 16-slice mobile CT scan has high resolution,fine imaging quality,low radiation dose,small power consumption and stable working performance.
2.Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1.
Na KONG ; Xiaying CHEN ; Jiao FENG ; Ting DUAN ; Shuiping LIU ; Xueni SUN ; Peng CHEN ; Ting PAN ; Lili YAN ; Ting JIN ; Yu XIANG ; Quan GAO ; Chengyong WEN ; Weirui MA ; Wencheng LIU ; Mingming ZHANG ; Zuyi YANG ; Wengang WANG ; Ruonan ZHANG ; Bi CHEN ; Tian XIE ; Xinbing SUI ; Wei TAO
Acta Pharmaceutica Sinica B 2021;11(12):4045-4054
Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation. Currently, the therapeutic role of ferroptosis on cancer is gaining increasing interest. Baicalin an active component in