Objective To investigate the values of degree centrality (DC),a novel resting-state fMRI parameter,in voxel-wise whole-brain ftmctional networks analysis in patients with irritable bowel syndrome (IBS).Methods The resting-state functional MR imaging was performed in 21 IBS patients and 21 age-,education level-,and gender-matched normal healthy subjects,collected in our hospital from August 2013 to January 2015.DC map changes between the two patient groups were compared by two sample t test.Results As compared with the control group,patients with IBS showed significantly reduced DC values in right superior frontal gyrus,middle frontal gyrus,middle frontal gyrus of orbital part,middle temporal gyrus and precuneus.Conclusion Changes of DC value occurr in some regions of brain in the IBS patients;DC,as a novel resting-state functional MRI parameter in the voxel-wise whole-brain functional networks,might be an appealing altemative index for further studying on pathologic and neuropsychological states of IBS.