3.Surgeon's decision upon pathological judgement.
Chinese Journal of Surgery 2009;47(20):1523-1524
7.Studies on chemical constituents from bark of Morus nigra.
Lei WANG ; Hong-Qing WANG ; Ruo-Yun CHEN
China Journal of Chinese Materia Medica 2007;32(23):2497-2499
OBJECTIVETo investigate the chemical constituents in the barks of Morus nigra.
METHODThe nine compounds were isolated and purified by column chromatography over silica gel, LH -20 and preparative HPLC and their structures were identified by various spectroscopic methods.
RESULTThe nine compounds were isolated and identified as olcancolic acid , apigenin, cyclocommunol, morusin, cyclomorusin, kuwanon C, daucosterol, ursolic acid, 63-sitosterol.
CONCLUSIONOlcancolic acid, apingenin, cyclocommunol, morusin, cyclomorusin, kuwanon C, daucosterol were firstly isolated from the M. nigra.
Apigenin ; analysis ; chemistry ; isolation & purification ; Chromatography ; methods ; Chromatography, High Pressure Liquid ; Flavonoids ; analysis ; chemistry ; isolation & purification ; Mass Spectrometry ; methods ; Morus ; chemistry ; Oleanolic Acid ; analysis ; chemistry ; isolation & purification ; Plant Bark ; chemistry ; Plants, Medicinal ; chemistry
8.Minor triterpenoid acids from an aqueous extract of Uncaria rhynchophylla
Qing ZHANG ; Xiao-qiang LEI ; Ruo-fei LI ; Hua SUN ; Cheng-bo XU ; Cheng-gen ZHU ; Qing-lan GUO ; Jian-gong SHI
Acta Pharmaceutica Sinica 2023;57(4):992-1002
Seventeen minor triterpenoid acids (
9.Flavonol glycosides from Lysimachia clethroides.
Dong LIANG ; Yan-Fei LIU ; Zhi-You HAO ; Huan LUO ; Yan WANG ; Chun-Lei ZHANG ; Qing-Jian ZHANG ; Ruo-Yun CHEN ; De-Quan YU
China Journal of Chinese Materia Medica 2015;40(1):103-107
Eleven flavonol glycosides were isolated from the ethanol extract of Lysimachia clethroides by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were identified as astragalin (1), isoquercitrin (2), isorhamnetin-3-O-β-D-glucopyranoside (3), quercetin-3-O-β-D-6"-acetylglucopyranoside (4), quercetin-7-O-β-D-glucopyranoside (5), prunin (6), 2-hydroxynaringin-5-O-β-D-glucopyranoside (7), kaempferol-3-O-rutinonoside (8), kaempferol-3-O-robinobioside (9), rutin (10) and kaempferol-3,7-di-O-β-D-glucopyranoside (11). Among them, compounds 4, 7 and 11 were obtained from the Lysimachia genus for the first time, while compounds 3, 5 and 9 were firstly reported from this plant. In the preliminary assays, compounds 2, 6 and 8 possessed significant inhibition against aldose reduc- tase, with IC50 values of 2.69, 1.00, 1.80 μmol · L(-1), respectively; none of compounds 1-11 exhibited obvious cytotoxic activity (IC50 > 10 μmol · L(-1)).
Drugs, Chinese Herbal
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chemistry
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Flavonols
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chemistry
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Glycosides
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chemistry
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Molecular Structure
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Primulaceae
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chemistry
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Spectrometry, Mass, Electrospray Ionization
10.Update in the research of gene therapy for pancreatic carcinoma.
Min WANG ; Yi-lin WANG ; Ruo-qing LEI ; Dian-xu FENG
Acta Academiae Medicinae Sinicae 2005;27(5):648-653
With the advances in immunology and molecular biology, new recognition in the pathogenesis, progression, and metastasis of carcinoma have been achieved. Studies on gene therapy for pancreatic carcinoma have been attempted in different ways, such as inhibiting oncogene, activating tumor suppressor gene, inducing apoptosis, applying gene directed enzyme prodrug therapy, and immune activation. New specific target genes and further development of gene technology may bring the break-through in this field.
Animals
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Genes, Tumor Suppressor
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Genetic Therapy
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methods
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Humans
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Immunotherapy
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Pancreatic Neoplasms
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genetics
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immunology
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therapy