Objective To summary 9 cases of histiocytic necrotizing lymphadenitis(HNL) of children and discuss the diagnosis and therapy.Methods Reviewed clinical data and histological findings.Nine cases of HNL from 1999 to 2003 years.Results All patients had fever and swelling of lymph node on neck.They were diagnosed by lymph node excisional biopsy.Six cases were administrated of glucocorticoid and benefited significantly.Conclusions The etiological factor and pathogenesis is unknown,yet.The clinical situation is not characterful.The diagnosis is always established by histopathology. The effect of management using glucocorticoid is remarkable.A long course can probably decrease recurrence.

Biomarkers, Tumor ; metabolism ; Carcinoma, Hepatocellular ; genetics ; metabolism ; CpG Islands ; Cyclin-Dependent Kinase Inhibitor p57 ; genetics ; metabolism ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization ; Liver ; metabolism ; Liver Neoplasms ; genetics ; metabolism ; Polymerase Chain Reaction ; methods ; Promoter Regions, Genetic ; RNA, Messenger ; genetics ; metabolism

OBJECTIVE: To study the association of body fat ratio with precocious puberty in girls. Previous studies have shown that body mass index (BMI) is associated with the girls' age of puberty but have not revealed the association of body fat ratio with age of puberty. METHODS: Based on the consensus on the diagnosis and treatment of central precocious puberty (CPP), 128 children with precocious puberty who were admitted to the hospital from July to August, 2017, were divided into a CPP group with 87 children and a peripheral precocious puberty (PPP) group with 41 children. A total of 51 girls without any puberty development signs were enrolled as the control group. Dual-energy X-ray absorptiometry was used to measure the body fat ratios of upper limbs, legs, trunk, android area, gynoid area, and the whole body. The association between body fat ratios and precocious puberty was analyzed with reference to age, BMI, BMI-Z score, bone age, ovarian volume, and hormone levels. RESULTS: Compared with the control group, the CPP and PPP groups had significantly higher body fat ratios of upper limbs, legs, trunk, android area, gynoid area, and the whole body, legs/whole body fat ratio, and (upper limbs+legs)/trunk fat ratio (P<0.05), while there were no significant differences in the above body fat ratios and fat distribution indicators between the CPP and PPP groups (P>0.05). For the girls with precocious puberty, the high body fat ratio group had significantly higher luteinizing hormone (LH) base value, luteinizing hormone releasing hormone (LHRH)-stimulated LH peak value, and LH/follicle-stimulating hormone peak value than the low body fat ratio group (P<0.05). Compared with the control group, both the high body fat ratio and low body fat ratio groups had a significantly higher LH base value (P<0.05). CONCLUSIONS The increase in body fat may be a factor inducing precocious puberty in girls, but further studies are needed to determine the mechanism.
Adipose Tissue ; Child ; Female ; Follicle Stimulating Hormone ; Gonadotropin-Releasing Hormone ; Humans ; Luteinizing Hormone ; Puberty, Precocious ; Sexual Maturation

Objective To research the role of lymph tracers to protect parathyroid in surgery for papillary thyroid carcinoma.Methods Patients with papillary thyroid carcinoma who met selected criteria were enrolled in this study.Patients were divided into carbon nanoparticle group,methylene blue group,and conventional surgery group.Results No significant complication occurred in the patients of carbon nanoparticle and methylene blue groups.In carbon nanoparticle group,methylene blue group and conventional surgery group,the mean numbers of parathyroid glands detected during surgery were 3.1 ± 0.3,2.9 + 0.4 and 2.3 ± 0.3 (F =3.78,P ＜ 0.01),the rates that parathyroid was cut mistakenly were 1.37％(2/146),2.62％ (2/97) and 7.14％ (6/84) respectively(x2 =17.372,P ＜ 0.05) ; and the incidence of postoperative hypocalcemia were 10.4％ (5/48),9.1％ (3/33) and 17.5％ (7/40,x2 =0.671,P =0.037).Conclusion Thyroid lymphography technique is helpful to protect from the injury to the parathyroid glands in surgery.

Objective To evaluate the necessity of drainage after thyroidectomy for benign thyroid disorders.Methods A total of 272 patients who underwent thyroidectomy for benign thyroid disorders were randomly divided into drainage group or non-drainage group.Operating time,postoperative stay time in hospital,comfort of neck assessed by visual analogue scale (VAS) on postoperative day (POD) 0 and PODI were and the incidence of complications,including post-thyroidectomy bleeding,hematoma,seroma,wound infection,hoarseness,and hypoparathyroidism,were assessed and compared between two groups.Results Both groups were similar in the mean age,the sex ratio and the underwent procedure types.There was no significant difference in the mean operating time between two groups (87.5 ± 32.0) min and (93.8 ± 30.1) min (t =0.12,P =0.45).The mean postoperative hospital stay time of non-drainage group (1.9 ± 0.3) d was significantly shorter than that of drainage group (2.6 ± 0.6) d (t =1.45,P =0.02).The mean VAS scores of neck comfort on POD0 and POD1 in non-drainage group were significantly high than those in nondrainage group (t =2.67,P =0.03 and t =0.33,P =0.006).There were no significant difference in postoperative complications,including permanent hoarseness and hypoparathyroidism,between two groups.Conclusions No drainage after thyroidectomy for benign thyroid disorders does not increase postoperative complications,with the increase in postoperative neck comfort,the decrease in hospital stay time and potential wound infections.The routine drainage is not necessary after thyroid surgery for benign disorders.

Objective To discuss the effect of community intervention on visual analogue scale ( VAS ) , Oswestry disability index ( ODI ) and frequency of drug use in patients with lumbar degenerative disease ( LDD) .Methods Forty-one patients with LDD were applied with 3 months of community intervention , self-made DV on health guide and handbook on rehabilitation training were handed out , community lecture was carried out and telephone interview was conducted .VAS and ODI were used to evaluate patients ’ pain and function of lumbar vertebra , and the frequency of drug use was collected 3 months before and after the intervention.Results The correct rate of training on lumbar posture and dorsal muscles was 92.68% after the intervention, higher than 17.07% before the intervention, and the difference was statistically significant (χ2 =47.33,P<0.001).The score of VAS on lumbar and VAS on lower limbs , the frequency of drug use and the score of ODI was respectively (2.65 ±0.82),(2.60 ±1.01),(1.51 ±0.71),(10.95 ±4.52) before intervention, and (2.05 ±0.69),(1.94 ±0.87),(0.98 ±0.57),(8.46 ±3.49)after the intervention, with statistically significant differences (t=6.82,7.07,6.81,9.87, respectively; P <0.00).Conclusions Community intervention can promote the improvement of symptoms and recovery of body function for patients with LDD .

With the development of the new generation of 16S rRNA sequencing technology and metagenomics, the relationship between the microbiota and bronchial asthma (asthma for short) has been increasingly recognized, and has become a research hotspot in the pathogenesis of asthma. It is estimated that more than 10,000 different microbial species inhabit the human body, affecting nutrition, metabolism and immune function of body. The imbalance of microbial flora leads to the disturbance of the internal environment in the body, which causes diseases such as asthma. Asthma is determined by both genetic and environmental effects, and the microbiota plays an important role in the pathogenesis, phenotype and disease severity of asthma. This paper reviews the role of different microbiota in the development of asthma.

Objective With the widespread of transcatheter aortic valve replacement(TAVR)in patients with severe symptomatic aortic stenosis(AS),the life-cycle management has become a major determinant of prognosis.Methods A total of 408 AS patients who underwent successfully TAVR from June 2021 to August 2023 were consecutively enrolled in Hospital Valve Intervention Center.Patients were assigned to the Usual Care(UC)group between June 2021 and October 2022,while patients were assigned to the Heart Multi-parameter Monitoring(HMM)group between November 2022 and August 2023.The primary endpoint was defined as composite endpoint within 6 months post-TAVR,including all-cause death,cardiovascular death,stroke/transient ischemic attack,conduction block,myocardial infarction,heart failure rehospitalization,and major bleeding events.Secondary endpoints were the time interval(in hours)from event occurrence to medical consultation or advice and patient satisfaction.Statistical analysis was performed using Kaplan-Meier and multivariable Cox proportional hazards models.Results The incidence of primary endpoint in HMM group was significantly lower than that in UC group(8.9％vs.17.7％,P=0.016),the driving event was the rate of diagnosis and recognition of conduction block.The average time intervals from event occurrence to receiving medical advice were 3.02 h in HHM group vs.97.09 h in UC group(P＜0.001).Using cardiac monitoring devices and smart healthcare platforms provided significant improving in patients long-term management(HR 0.439,95％CI 0.244-0.790,P=0.006).Conclusions The utilization of cardiac monitoring devices and smart healthcare platforms effectively alerted clinical events and improved postoperative quality of life during long-term management post TAVR.

In this study, we aimed to establish a rat liver micro-tissue evaluation system to evaluate the hepatotoxicity of the main monomers in Polygonum multiflorum. Rat primary hepatocytes were isolated and purified by two-step in situ perfusion method to prepare hepatic parenchymal cells. The ultra-low adsorption plate and the inverted model were used to establish an in vitro hepatotoxicity evaluation system. After the system was established, the main monomer components(monanthone with emodin type, rhein, emodin, emodin-8-O-β-D-glucopyranoside, physcion) of P. multiflorum were selected for in vitro hepatotoxicity evaluation. This study showed that the primary cells of the liver can form liver micro-tissues in the low adsorption plate method and the mold perfusion method, with good liver structure and function, which can be used to evaluate the hepatotoxicity of the drug to be tested after long-term administration. The five monomers to be tested in P. multiflorum can significantly affect the proliferation of primary liver micro-tissues in rats in a dose-and time-dependent manner. The hepatotoxic effects were as follows: monanthone with emodin type > rhein > emodin > emodin-8-O-β-D-glucopyranoside > physcion. The results suggested that the emodin-type monoterpene and rhein might be the potential hepatotoxic components, while the metabolites of emodin-8-O-β-D-glucoside and emodin methyl ether showed more toxic risks. The rat primary hepatocyte micro-tissue model system established in this experiment could be used to achieve long-term drug administration in vitro, which was consistent with the clinical features of liver injury caused by long-term use of P. multiflorum. The experimental results provided important information and reference on the clinical application and toxic component of P. multiflorum.
Animals ; Chemical and Drug Induced Liver Injury ; Emodin ; Fallopia multiflora ; Glucosides ; Plant Extracts ; Polygonum ; Rats