Tumor immune microenvironment has been the focus of tumor research in recent years, and its role in tumor regulation has become prominent and has received increasing attention. The imbalance of the tumor immune microenvironment plays an important role in promoting tumor progression, and the adjustment of its instability plays an important role in controlling tumor progression. The theoretical idea of Traditional Chinese Medicine's "Yipingweiqi" is basically the same as that of modern medicine of controlling tumors by maintaining the balance of the immune microenvironment. This study discusses the aspects of tumor immune microenvironment, its destabilization, relationship to tumor progression, importance in Traditional Chinese Medicine, and regulation by Traditional Chinese Medicine with different treatments. In particular, this work focuses on the role of Traditional Chinese Medicine in maintaining the balance of the tumor immune microenvironment and its potential mechanism by using qi benefit, yang warming, dampness eliminating, and heat clearing under the guidance of the principle of "Yipingweiqi". Results will provide reference for the application of Traditional Chinese Medicine in the diagnosis and treatment of tumors.

Objective:To investigate the use intention of patients with coronary heart disease for mobile health and understand needs of patients for gamification design of mobile health platform, in order to improve the self-management level of patients with coronary heart disease by building a gamified mobile health platform.Methods:Using the convenient sampling method, a total of 181 hospitalized patients with coronary heart disease (CHD) in Department of Cardiology from July to September 2020 (3 hospitals in Beijing and 1 hospital in Heilongjiang Province) were selected as research objects. Questionnaire on the usage needs of mobile health platform for coronary heart disease was used to investigate them.Results:Only 8 of the 181 patients (4.42%) used cardiac mobile health, and 113 (62.43%) patients never used cardiac mobile health but would consider using it. But 60 (33.15%) patients never used cardiac mobile medical experience and said that they won' t use it in the future, and the reasons included operation, language, safety, need awareness and health concerns. Among 121 patients with coronary heart disease, the top three requirements for gamification design were human-computer interaction encouragement and company (32.23%) , completion of tasks to exchange for real prizes (30.58%) and health ranking (28.10%) .Conclusions:Based on needs of patients, an easy-to-use, scientific and readable gamified mobile health platform for coronary heart disease should be built, mobile health publicity should be increased, and the continuous use rate of the mobile health platform and the self-management of patients should be improved.

Objective:To understand the current situation and needs of nursing staff on the development of specialization in traditional Chinese medicine (TCM) nursing.Methods:In July 2020, the convenient sampling method was used to select 120 nursing staff from 7 tertiary hospitals and 1 secondary hospital in Beijing as the research objects. Through literature search, the questionnaire on the Current Situation and Needs of the Specialized Development of TCM Nursing was self-designed to conduct a questionnaire survey.Results:In this study, electronic questionnaires were used. A total of 120 questionnaires were distributed and 116 questionnaires were returned, of which 114 were valid questionnaires. The results of the survey showed that nurses supported the specialization of TCM nursing and actively practiced TCM nursing measures in their work. A total of 97.37% (111/114) of the nurses had the demand to participate in the TCM specialty certification. The main difficulties in developing the specialized development of TCM nursing were the unclear connotation of TCM nursing, the controversial positioning of the discipline, and insufficient government support.Conclusions:The development of the specialization of TCM nursing is the inevitable development of the discipline, and there is a strong demand for professional development and social demand.

The occurrence of malignant tumors is closely related to the ministerial fire. The variant ministerial fire is the fundamental factor of the formation of cancer toxin， and ministerial fire dislocation and hyperactivity are the basis for the generation of variant ministerial fire. When the ministerial fire cannot keep its position or moves without restraint， burning and exuberant， the variant ministerial fire comes out. Under the guidance of the theory of ministerial fire， the basic treatment methods to differentiate and treat malignant tumors are the direct repulsion of variant ministerial fire， and the regulation of dislocated and hyperactive ministerial fire. The method of clearing heat and resolving toxins is often used， taking a large amounts of bitter and cold herbs to reduce variant ministerial fire. For ministerial fire dislocation， ministerial fire depletion， true yang insufficiency， and the ministerial fire failing to rely on， it is common to have symptoms of upper heat and lower cold， for which the treatment method is to benefit the source of the fire， and Modified Yinhuo Decoction （引火汤加减） is commonly used. For insufficient true yin and lack of support for ministerial fire， it is suggested to nourish kidney essence， and the medicinals of enriching yin and boosting kidney are commonly used. In terms of ministerial fire hyperactivity， the treatment method should be nourishing the heart and calming the mind， and Jiaotai Pills （交泰丸） is often used to clear heart and clam the mind， and return fire to its origin. At the same time， methods such as regulating qi， resolving phlegm， clearing fire， and dispelling stasis are used to clear away tangible pathogens， so that the ministerial fire acts in a controlled manner and keeps its position and destiny.

Objective To analyze the correlation between the condition of patients with spastic cerebral palsy, including age, sex, weight, number of the affected limb and gross motor function and their rehabilitation effect after selective posterior rhizotomy (SPR), and to explore the possible factors that contribute to the rehabilitation of motor function in patients with spastic cerebral palsy.Methods Totally 53 patients with spastic cerebral palsy admitted in the Departments of Orthopedics and Rehabilitation of Dongzhimen Hospital, Beijing University of Chinese Medicine were selected from October 2013 to October 2015. The patients received uniform and standard rehabilitation treatment after SPR, and their motor function was evaluated with the Gross Motor Function Measure (GMFM) before the surgery and six months after the surgery. Then the correlation between the patients' age, sex, weight, GMFM score before treatment and number of the affected limb and the difference in their motor function before and after treatment was analyzed.Results The patients' score in improved motor function was negatively correlated with their age (r=-0.30,P<0.01) and weight (r=-0.30, P<0.01), and not correlated with their sex (r=0.00,P=1.00), motor function before treatment (r=-0.20,P>0.05) or number of the affected limb (r=-0.20,P>0.05).Conclusions For patients aged between 3 and 25, the earlier they are treated, the better the effect is. The patients should control their weight properly so as not to affect the rehabilitation effect after surgery. The patients' sex, motor function before treatment and number of the affected limb cannot help to predict the recovery of their motor function after surgery. Researchers will continue to conduct large-sample and multi-factor studies in order to verify the current conclusions and analyze the influencing factors of SPR effect in a more comprehensive way.

Objective To explore the status of knowledge graph-based research into breast cancer micro-environment and to predict future research hotspots.Methods The literature related to breast cancer microenvironment in recent 20 years was retrieved from CNKI and Web of Science Core Collection database and analyzed with CiteSpace and VOSviewer.Results A total of 825 Chinese articles and 16,221 English articles were retrieved.Visual analysis showed that research focus has gradually shifted from cellular research to molecular research and drug innovation.Cancer stem cells,PD-1,PD-L1,immune checkpoint inhibitors,and nanoparticles are the main subjects of interest in research on breast cancer microenvironment,and the United States has the largest number of studies on breast cancer microenvironment,followed by China and Italy.Conclusion Current research mainly focuses on tumor stemness,immunotherapy,and nanodeli-very.Owing to deepening research in this field,the targeting of the breast cancer microenvironment for the prevention of tumor development and metastasis and improvement of tumor prognosis has emerged as a new research direction.

This article interprets and explores the recommendations of Clinical Best Practice Guidelines: Developing and Sustaining Nursing Leadership (Second Edition) published by the Registered Nurses' Association of Ontario (RNAO) in 2013. This article also analyzes the practical methods and accessibility of the guideline recommendations in clinical application, so as to provide a basis for the development and maintenance of clinical nursing leadership in China.

Objective To evaluate the efficacy of wax therapy for diabetic peripheral neuropathy, in order to provide suggestions for treatment and prevention.Methods Cochrane Library, JBI, PubMed, EMbase, CBM, CNKI, WANFANG DATA, VIP were searched by computer from inception to October, 2016 for randomized control trails in wax therapy for diabetic peripheral neuropathy. Two researchers searched and selected articles independently and the quality was assessed in accordance with Cochrane Manual. The articles were analyzed with Review Manager 5.3, and the evidence quality was assessed with GRADE profiler 3.6.1 software.Results A total of 8 randomized controlled trials were included. The number of literature quality grade A of original research is 3, while the number of literature quality grade B of original research is 4,and the number of literature quality grade C of original research is 1. Meta-analysis showed that the sensory nervus peronaeus conduction velocities improved by wax therapy for diabetic peripheral neuropathy patients,[MD=2.51, 95%CI(1.35,3.66), P<0.01]. By the GRADE system grading, the evidence quality is moderate.Conclusions The effect of wax therapy for diabetic peripheral neuropathy can improve the sensory nurve conduction velocities and speed of blood circle, so as to prevent ulcer of diabetic feet. Therefore, the clinical curative effects of the therapy require large-sample and high quality studies to confirm.