Diabetic retinopathy(DR)is a neurovascular unit lesion caused by diabetes mellitus,the incidence of which has increased significantly with the increase of the diabetic population.Therefore,it is important to use a reasonable animal model to explore the pathogenesis and therapeutic targets of DR.The db/db mouse is a relatively mature animal model of spontaneous type 2 diabetes and is therefore widely used in early prevention and treatment studies of type 2 DR.This paper describes the progress of db/db mouse model in exploring the pathogenesis of DR and the pharmacological research of Chinese and Western medicine,in order to provide a certain reference for the research of DR and drug development.

Objective:To provide a reference for in-depth application and research in the field of coronary heart disease traditional Chinese medicine (TCM) nursing. Based on the CiteSpace software, the development trend and research hotspots of the literature are displayed and analyzed in this field.Methods:The China Knowledge Network (CNKI) database was used to retrieve the literature related to the research in this field published in the past 20 years from January 1st 2001 to October 5th 2021, and CiteSpace was used to visually analyze the number of articles, research institutions, authors and keywords, and to interpret its meaning in combination with the content of the atlas.Results:The amount of research literature in this field was generally on the rise, but the cooperation between various research institutions and authors needs to be strengthened. Research hotspots mainly focused on five areas: coronary heart disease-related symptom care, the application of characteristic TCM nursing techniques, the outcome indicators of the research, the TCM health management of patients with coronary heart disease, and the application model of TCM nursing.Conclusions:It is recommended to strengthen multidisciplinary and teamwork in this field, carry out high-quality randomized controlled studies, and focus on related research on multiple nursing models, evaluation tools, and symptom management.