Objective To investigate the value of 99Tcm-3PRGD2 SPECT/CT imaging in the diagnosis of benign and malignant lung lesions.Methods A retrospective analysis of 99Tcm-3PRGD2 planar imaging and chest SPECT/CT imaging with lung lesions before treatment was performed.Totally 37 cases including 27 malignant and 10 benign lesions confirmed pathologiclly were enrolled.Compared with hepar in planar imaging,the intake gray scale of 99Tcm-3PRGD2 in lung lesions was divided into low,moderate,and high elevations.The ratio of the highest intake value of the lesion (L) to the contralateral normal lung (N),the hepar (H),the mediastinum (Me) and the contralateral deltoid muscle (Mu) was calculated,and statistical analysis was performed to evaluate the diagnostic efficacy.The expression of immunohistochemistry integrin αvβ3 was performed through selecting 1 case of benign and malignant lung lesions,respectively.Results The intake of 99Tcm-3PRGD2 was higher in 37 patients with lung lesions.High elevation of malignant lesion was 66.67％ (18/27),low and moderate elevation of benign lesion was 90.00％ (9/10).The intake ratio of malignant lung lesions was higher than that of benign lesions (all P＜0.05).When L/N was greater than 5.45 or L/Mu was greater than 4.65,the sensitivity,specificity and accuracy of diagnosis of lung malignant lesions was 77.80％,80.00％ and 78.40％,respectively.Immunohistochemical results showed that malignant lung lesions highly expressed integrin αvβ3,and only a small number of benign lesions expressed it.Conclusion 99 Tcm-3PRGD2 SPECT/CT is valuable in the differential diagnosis of benign and malignant lung lesions.

Objective To evaluate the effectiveness and benefit of influenza vaccination among school-age children in Xining, Qinghai. Methods A total of 215 children were randomly recruited as the vaccination group and vaccinated with trivalent split influenza vaccine. At the same time, 215 healthy children (no known diseases and past history reported, and no vaccinations) who underwent physical examinations during the same period were selected as the control group. The basic demographic information was investigated and a 1-year follow-up was carried out. Results The demographic characteristics of children in the vaccinated group and the control group were not significantly different (P>0.05), and were comparable between the two groups. After four follow-up visits within one year for the enrolled children, the overall incidence of influenza-like illness in children in the vaccinated group and the control group was 7.4% (16/215) and 16.7% (36/215), respectively, and the difference was statistically significant (χ²=8.75, P<0.05). The protection rate was 55.7%, and the protection index was 2.26. The common cold incidence rates in the two groups were 16.7% (36/215) and 25.6% (55/215), respectively, and the difference was statistically significant (χ²=5.03, P<0.05). The protection rate was 35.0%, and the protection index was 1.54. The incidence of other respiratory diseases was 1.8% (4/215) and 3.8% (8/215), respectively, and the difference was not statistically significant (χ²=1.37, P>0.05). The protection rate was 52.6%, and the protection index was 2.11. The proportions of irrational use of antibiotics were 6.0% (13/215) and 20.9% (45/215), respectively, and the difference was statistically significant (χ²=20.41, P<0.05). The protection rate was 71.3%, and the protection index was 3.48. The per capita income from vaccination was 667.9 yuan, and the benefit-cost ratio was 9.97:1. Conclusion Influenza vaccination for school-age children can effectively prevent the incidence of influenza-like diseases and the common cold, and the vaccination is cost-effective.