Objective To make a survey on common cosmetic allergens, and to provide epidemiological data and clinical evidence for cosmetic allergy. Methods Patch test was performed by using 49cosmetic allergens from a European cosmetic series and 5 Chinese standard screening allergens on 89patients with suspected cosmetic allergic contact dermatitis. Test results were determined according to the International Contact Dermatitis Research Group (ICDRG) recommendation. Results Of the 89 patients, 61(68.5%) showed positive reactions to one or more cosmetic allergens. The most common allergens were fragrances (33.7%), followed by preservatives (30.3%), para-phenylenediamine (25.8%) and amerchol L 101(10.1%). Conclusion Fragrances, preservatives, para-phenylenediamine and amerchol L 101 are dominant causative allergens in patients with cosmetic allergic contact dermatitis.

Objective:To analyze the research hotspots of self-management in patients with chronic obstructive pulmonary disease (COPD) at home and abroad.Methods:Related literature on self-management of COPD patients were searched in China National Knowledge Infrastructure and Web of Science databases, and the searched period was from January 1, 2013 to June 30, 2023. CiteSpace 5.8 software was used for keyword cluster analysis.Results:A total of 641 articles in Chinese and 1 192 in English were obtained. Domestic research hotspots about self-management of COPD patients mainly focused on health education, continuing care, rehabilitation care, etc. Foreign research hotspots about self-management of COPD patients mainly focused on mobile health, telemedicine and so on.Conclusions:This paper analyzes the research hotspots of self-management of COPD patients at home and abroad and provides reference for future research on self-management of COPD patients.

Objective To study the epidemiological characteristics of family cancer history in patients with nasopharyngeal carcinoma in Dongguan city. Methods A total of 240 patients with nasopharyngeal cancer treated in our hospital from January 2017 to January 2021 were selected for the investigation of family cancer history. The families of the patients were determined respectively, and the family cancer history of the first, second and third relatives was obtained. The incidence, population distribution and incidence factors were investigated and analyzed. Results A total of 7 918 primary, secondary and tertiary relatives of 240 cases were inquired. 188 cases were found to have cancer, including 118 cases of nasopharyngeal cancer and 70 cases of non-nasopharyngeal cancer (10 cases of digestive tract cancer, 18 cases of breast cancer, 20 cases of lymphoma and 22 cases of lung cancer). The incidence of familial cancer was higher in males (127/240) than in females (79/188). The main pathological type of family cancer was squamous cell carcinoma (109/188), accounting for 57.98%. Most of the patients in family cancer group were farmers (128/188), accounting for 68.09%; There was no significant difference in the prevalence of nasopharyngeal carcinoma and non-nasopharyngeal carcinoma in relatives of different genders (χ²=0.11, χ²=0.23, P>0.05). The incidence of cancer in first-degree relatives of different genders was higher than that in second-degree relatives, and the differences were statistically significant (χ²=4.26, χ²=5.62, P<0.05). The peak age of nasopharyngeal carcinoma family cancer patients was 40 to 49 years old group (39.36%). The familial cancer group regular intake of salted fish (>2 times per week), Epstein-Barr virus infection was significantly higher than that of the familial non-cancer group, the difference was statistically significant (χ²=6.57, χ²=10.59, P<0.05). Conclusions The incidence of cancer and nasopharyngeal cancer in first-degree relatives is significantly higher than that in second-level and third-level relatives. The occurrence of nasopharyngeal cancer is the result of the combined action of genetic factors and environmental factors. It is necessary to carry out health education for the families of nasopharyngeal cancer, Avoid eating and curing foods, and actively improve production and living environment, so as to reduce the incidence rate of nasopharyngeal carcinoma.

Objective: To investigate the efficacy and safety of the recombinant human tumor necrosis factor receptor Ⅱ-IgG Fc fusion protein (rhTNFR: Fc, etanercept) for the treatment of occupational medicamentosa-like dermatitis induced by trichloroethylene (OMLDT) . Methods: In September 2011 to February 2016, 12 patients with OMLDT were treated with etanercept 25 mg, subcutaneous injection, twice per week, doubling of first dose. The course of treatment was 6 weeks. The drug eruption area and severity index (DASI) score, the proportion of patients achieving a 50%, 75% and 90% reduction in DASI (DASI50, DASI75, DASI90) and the serum level of TNF-α were used to assess the efficacy at different times. Adverse reactions were also recorded and evaluated. The results were statistically analyzed by nonparametric Friedman test and repetitive measurement ANOVA using the software SPSS19.0. Results: After 4 weeks treatment, the DASI score decreased form 56.33±7.02 to 0.50±0.91 (P<0.01) . The DASI50, DASI75 and DASI90 were all increased to 12 (100%) . The serum level of TNF-α decreased form (43.74±41.62) pg/ml to (3.03±0.47) pg/ml (P<0.01) . Statistically significant difference was observed from the above indexes. There were no adverse reactions in clinical application. Conclusion Recombinant human tumor necrosis factor receptor Ⅱ-IgG Fc fusion protein may be a safe and effective drug in the treatment of OMLDT.