Objective To establish Chinese nurses'work-stress model.Methods Make assessment with nurses stress source,working fatigue,self-assess psychology,press reaction,life events,social support etc.based on the path analysis,and validate the NSS model proposed.Results Nurses'NSS had significant effect on pressure reaction,working fatigue and psychological symptoms in ascending order.Nurses'passive style of dealing with NSS was a significant variable in the process of work stressor.since it could affect the maladjustment in three ways:affecting pressure reaction,fatigue,affecting the engenderment of ill psychological symptoms via NSS indirectly,and affecting life events and ill psychological symptoms directly.Life could events could affect NSS in two ways:affect maladjustment directly and coilaborate with NSS indirectly.Social support could affect NSS and the eonsequence of stress adaptation via life events.Conclusions Verified with the theory model and can be used to explain the process of nurse working stress.