Objective To explore the influence of self-acceptance and academic achievement on career adaptability, and the mediating effect of academic achievement between self-acceptance and career adaptability among nursing undergraduates. Methods In September 2017, we selected 281 nursing undergraduates from Grade 1 to 3 of School of Nursing at China Medical University as subjects by convenience sampling. All of the patients were investigated with the College Students' Career Adaptability Questionnaire (CSCAQ), Unconditional Self-acceptance Questionnaire (USAQ) and Academic Achievement Scale. Results The average score of CSCAQ, USAQ and academic achievement scale of nursing undergraduates were (3.70±0.39), (3.64±0.51) and (3.51±0.46) respectively. Nursing undergraduates' career adaptability had positive correlations with self-acceptance and academic achievement (r=0.395, 0.382; P＜ 0.05). Three-step mediating regression analysis showed academic achievement played a partial mediating effect in the influence of self-acceptance on career adaptability with a significant mediating effect (P＜0.01). The mediating effect accounted for 27.94% of the total effect. Conclusions Nursing undergraduates' academic achievement has effects on their career adaptability. Their self-acceptance not only has effects on career adaptability directly, but also has effects on career adaptability by the mediating effect of academic achievement indirectly.

OBJECTIVETo investigate the role of MT-ND1 m.3635G>A mutation in the pathogenesis of Leber's hereditary optic neuropathy (LHON).

METHODSBiochemical characteristics including the activity of complex Ⅰ, ATP production and oxygen consumption rate among lymphoblastoid cell lines derived from 3 carriers, 3 affected matrilineal relatives of the families and 3 controls were compared.

RESULTSComparison of mitochondrial functions in lymphoblastoid cell lines of the carriers, patients and controls showed a 51.0% decrease in the activity of complex Ⅰ in patients compared with controls (P<0.05). The m.3635G>A mutation has resulted in decreased efficiency of ATP synthesis (P<0.05). Comparison of oxygen consumption rate showed that the basal OCR (P<0.05), ATP-linked OCR (P<0.05) and the maximum OCR (P<0.05) have all reduced to some extent compared with the controls.

CONCLUSIONThese results showed that m.3635G>A, as a LHON-associated mutation, can lead to mitochondrial dysfunction.

Adenosine Triphosphate ; genetics ; Asian Continental Ancestry Group ; genetics ; Female ; Humans ; Male ; Mitochondria ; genetics ; Mutation ; genetics ; NADH Dehydrogenase ; genetics ; Optic Atrophy, Hereditary, Leber ; genetics ; Pedigree