ObjectiveTo observe the effect of modified Zuoguiwan combined with perindopril tert-butylamine tablets on early diabetic kidney disease （DKD） of Qi-Yin deficiency with blood stasis syndrome. MethodA total of 77 patients with early DKD of Qi-Yin deficiency with blood stasis syndrome， who were treated in the Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from september 2020 to november 2021， were randomized into the control group （38 cases） and observation group （39 cases）. The control group received basic treatment and perindopril tert-butylamine tablets， and the observation group was treated with modified Zuoguiwan and perindopril tert-butylamine tablets in addition to the basic treatment. The treatment lasted 3 months for both groups. The symptom scores， blood glucose ［fasting blood glucose （FBG）， 2 h postprandial blood glucose （2 h PBG）， glycosylated hemoglobin （HbA1c）， time in range （TIR）］， serum creatinine （SCr）， urea， estimated glomerular filtration rate （eGFR）， cystatin-C （Cys-C）， serum beta 2-microglobulin （Sβ₂-MB）， and urinary microproteins ［24 h urinary microalbumin （24 h UmAlb）， 24 h micrototal protein （24 h MTP）， urine beta 2-microglobulin （Uβ₂-MB）］ were observed in two groups. ResultThe two groups showed no significant difference in the various indexes before treatment. After treatment， the total effective rate of the control group was 84.2% （32/38）， as compared with the 94.9% （37/39） in the observation group （Z=6.03， P<0.05）. After treatment， the symptom scores were lower than those before treatment in both groups （P<0.01） and lower in the observation group than in the control group （P<0.01）. TIR level was higher （P<0.05） and levels of FBG， 2 h PBG， and HbA1c （P<0.01） were lower than those before treatment in both groups. After treatment， the TIR level in the observation group was significantly increased as compared with that in the control group （P<0.01）. After treatment， the level of Cys-C was lower than that before treatment in both group （P<0.01） and lower in the observation group than in control group （P<0.01）. The level of Sβ₂-MB in both the observation group （P<0.05） and control group decreased as compared with that before treatment. The 24 h UmAlb and Uβ₂-MB of two groups were decreased after treatment as compared with those before treatment （P<0.05）. Moreover， 24 h MTP in observation group （P<0.05） was lower than that before treatment. After treatment， the levels of 24 h UmAlb， 24 h MTP and Uβ₂-MB in observation group were lower than those in control group （P<0.01）， and levels of SCr and eGFR in observation group did not change significantly as compared with those in the control group. ConclusionModified Zuoguiwan combined with perindopril tert-butylamine tablets can reduce blood glucose fluctuations and urinary albumin excretion in early DKD patients of Qi-Yin deficiency with blood stasis syndrome. The efficacy is better than that of basic western medicine.